A5016970306- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Autoimmune Neurological Disorders and Treatments
- Autoimmune and Inflammatory Disorders Research
- Genetics and Neurodevelopmental Disorders
- Acute Lymphoblastic Leukemia research
- Viral Infections and Immunology Research
- Polyomavirus and related diseases
- Adolescent and Pediatric Healthcare
- Infectious Encephalopathies and Encephalitis
- Herpesvirus Infections and Treatments
- Systemic Lupus Erythematosus Research
- RNA regulation and disease
- Epilepsy research and treatment
- Global Health Care Issues
- Childhood Cancer Survivors' Quality of Life
- Bacterial Infections and Vaccines
- Cutaneous Melanoma Detection and Management
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Neuroscience and Neuropharmacology Research
- Complement system in diseases
- Intergenerational Family Dynamics and Caregiving
- Long-Term Effects of COVID-19
Boston Children's Hospital
2016-2025
Harvard University
2016-2025
Boston Children's Museum
2014-2025
Children's Hospital
2023-2025
Boston University
2015-2024
Massachusetts General Hospital
2014-2024
University of Utah
2018-2024
Stanford University
2018-2024
Brigham and Women's Hospital
2009-2022
Cleveland Clinic
2018-2022
The rationale was to develop recommendations on the use of <sup>18</sup>F-FDG PET in breast, colorectal, esophageal, head and neck, lung, pancreatic, thyroid cancer; lymphoma, melanoma, sarcoma; unknown primary tumor. Outcomes interest included for diagnosing, staging, detecting recurrence or progression cancer. <b>Methods:</b> A search performed identify all published randomized controlled trials systematic reviews literature. An additional relevant unpublished reviews. These publications...
<h3>Objective</h3> To investigate whether or not the disparity in disease progression those with pediatric-onset compared adult-onset multiple sclerosis (MS) is due to differences relapse rates. <h3>Design</h3> Inception cohort. Mean follow-up times were 3.67 (standard deviation, 1.64) and 3.98 1.17) years pediatric adult groups, respectively. <h3>Setting</h3> Comprehensive MS centers. <h3>Patients</h3> Patients relapsing-remitting who seen at centers Massachusetts General Brigham Women's...
Background: Recognizing the cause of optic neuritis (ON) affects treatment decisions and visual outcomes. Objective: We aimed to define radiological features first-episode demyelinating ON. Methods: performed blinded assessment 50 patients presenting with myelin oligodendrocyte glycoprotein (MOG) antibody-associated ON (MOG-ON; n=19), aquaporin-4 (AQP4) (AQP4-ON; n=11), multiple sclerosis (MS)-associated (MS-ON; n=13), unclassified ( n=7). Results: Bilateral involvement was more common in...
<h3>Objective:</h3> To assess the utility and safety of rituximab in pediatric autoimmune inflammatory disorders CNS. <h3>Methods:</h3> Multicenter retrospective study. <h3>Results:</h3> A total 144 children adolescents (median age 8 years, range 0.7–17; 103 female) with NMDA receptor (NMDAR) encephalitis (n = 39), opsoclonus myoclonus ataxia syndrome 32), neuromyelitis optica spectrum 20), neuropsychiatric systemic lupus erythematosus 18), other neuroinflammatory 35) were studied. Rituximab...
To report the clinical features, comorbidities, receptor subunit targets, and outcome in patients with anti-GABAA (GABAAR) encephalitis.Clinical study of 26 patients, including 17 new (April 2013-January 2016) 9 previously reported patients. Antibodies to α1, β3, γ2 subunits GABAAR were determined using techniques.Patients' median age was 40.5 years (interquartile range 48.5 [13.75-62.35] years; youngest 2.5 months old; 13 female). Symptoms included seizures (88%), alteration cognition...
Abstract We sought to define the pathological features of myelin oligodendrocyte glycoprotein (MOG) antibody associated disorders (MOGAD) in an archival autopsy/biopsy cohort. histopathologically analyzed 2 autopsies and 22 brain biopsies from patients with CNS inflammatory demyelinating diseases seropositive for MOG-antibody by live-cell-based-assay full length MOG its conformational form. MOGAD (ages 52 67) demonstrate spectrum histopathological observed within (median age, 10 years;...
Identifying infectious causes of subacute or chronic meningitis can be challenging. Enhanced, unbiased diagnostic approaches are needed.To present a case series patients with diagnostically challenging using metagenomic next-generation sequencing (mNGS) cerebrospinal fluid (CSF) supported by statistical framework generated from mNGS control samples the environment and who were noninfectious.In this series, data obtained CSF 94 noninfectious neuroinflammatory disorders 24 water reagent used...
<h3>Objective</h3> Autoimmune encephalitis (AE) is an important and treatable cause of acute encephalitis. Diagnosis AE in a developing child challenging because overlap clinical presentations with other diseases complexity normal behavior changes. Existing diagnostic criteria for adult require modification to be applied children, who differ from adults their presentations, paraclinical findings, autoantibody profiles, treatment response, long-term outcomes. <h3>Methods</h3> A subcommittee...
Epilepsy is a debilitating condition, often with neither known etiology nor an effective treatment. Autoimmune mechanisms have been increasingly identified.To conduct population-level study investigating the relationship between epilepsy and several common autoimmune diseases.A retrospective population-based using claims from nationwide employer-provided health insurance plan in United States. Participants were beneficiaries enrolled 1999 2006 (N = 2 518 034).We examined 12 diseases: type 1...
To create an international consensus treatment recommendation for pediatric NMDA receptor antibody encephalitis (NMDARE).After selection of a panel 27 experts with representation from all continents, 2-step Delphi method was adopted to develop on relevant regimens and statements, along key definitions in NMDARE (disease severity, failure improve, relapse). Finally, online face-to-face meeting held reach (defined as ≥75% agreement).Corticosteroids are recommended children (pulsed IV...
Because common viruses are encountered during childhood, pediatric multiple sclerosis (MS) offers a unique opportunity to investigate the influence of these on disease susceptibility and interactions between seroprevalence select HLA genotypes. We studied for Epstein-Barr virus (EBV), cytomegalovirus (CMV), herpes simplex (HSV) type 1 HLA-DRB1*1501/1503 status as predictors MS.This was retrospective analysis prospectively collected demographic, clinical, biologic data in subjects up 18 years...
To review our multicenter experience with cyclophosphamide in the treatment of children multiple sclerosis (MS).Retrospective chart MS treated cyclophosphamide. Demographic, clinical, treatment, and MRI parameters were collected.We identified 17 All but one had worsening Expanded Disability Status Scale scores or relapses prior to initiation. Children three regimens: 1) induction therapy alone; 2) pulse maintenance therapy; 3) alone. Treatment resulted a reduction relapse rate stabilization...
In the largest sample studied to date, we measured cognitive functioning in children and adolescents with pediatric multiple sclerosis (n = 187) as well those clinically isolated syndrome 44). Participants were consecutively enrolled from six United States Pediatric Multiple Sclerosis Centers of Excellence. had a mean 14.8 ± 2.6 years age an average disease duration 1.9 2.2 years. A total 65 (35%) 8 (18%) met criteria for impairment. The most frequent areas involved fine motor coordination...