A5101670325- Pharmaceutical industry and healthcare
- Radiology practices and education
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Respiratory viral infections research
- Immune Response and Inflammation
- Diversity and Career in Medicine
- Inflammasome and immune disorders
- Ethics in Clinical Research
- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
- Radiation Dose and Imaging
- Data-Driven Disease Surveillance
- DNA and Biological Computing
- Liver Disease Diagnosis and Treatment
- Cell death mechanisms and regulation
- DNA and Nucleic Acid Chemistry
- Influenza Virus Research Studies
- Neuroblastoma Research and Treatments
- Infection Control in Healthcare
- Genetic Associations and Epidemiology
- Palliative Care and End-of-Life Issues
- Cancer, Hypoxia, and Metabolism
- Diabetes Management and Education
- Research on Leishmaniasis Studies
Yale University
2023-2025
University of South Carolina
2025
University of Massachusetts Amherst
2024
National University Health System
2020-2024
Vardhman Mahavir Medical College & Safdarjung Hospital
2024
University of Maryland, Baltimore
2024
National University of Singapore
2021-2024
University of North Carolina at Chapel Hill
2022
Savitribai Phule Pune University
2021
University of Piraeus
2021
Objectives: The purpose of this study was to compare the biomechanical properties posterolateral antiglide plating and lateral locked for fixation displaced short oblique fractures fibula in osteoporotic bone. Methods: Short distal at level syndesmosis were simulated with a fibular osteotomy ligamentous sectioning 18 paired fresh frozen ankles. fixed either locking plate an independent lag screw or through plate. specimens tested under torsional load failure. torque failure, angular rotation...
Host response aimed at eliminating the infecting pathogen, as well pathogen itself, can cause tissue injury. Tissue injury leads to release of a myriad cellular components including mitochondrial DNA, which host senses through pattern recognition receptors. How sensing by shapes anti-pathogen remains poorly understood. In this study, we utilized mice that are deficient in toll-like receptor-9 (TLR9), binds unmethylated CpG DNA sequences such those present bacterial and DNA. To avoid direct...
Abstract Background Chagas disease (CD), Trypanosoma cruzi infection, is a neglected vector-borne endemic in Latin America for which < 1% of cases have been treated. WHO estimates that ∼9,000 infected neonatal occur annually via vertical transmission—US CDC up to ∼300 incident annually. Maternal and misdiagnosis are principally attributed the paucity accurate diagnostic tools this complex chronic parasitic with current guidelines requiring confirmation testing at >9 months...
T he excitement of scientifi c research and discovery cannot be fully conveyed by didactic lectures alone.Several recent initiatives proposals, therefore, have supported a more participatory, discovery-based instruction for undergraduate science education [1,2].In functional genomics, we found an ideal platform to simultaneously benefi t students contribute discovery.The sequencing eukaryotic genomes has facilitated the identifi cation complete sets genes in humans model genetic...
The area and volume of brain structural features, as assessed by high-resolution three-dimensional magnetic resonance imaging (MRI), are among the most heritable measures relating to human CNS. We have conducted MRI scanning all available monkeys >2 years age (n = 357) from extended multigenerational pedigree Vervet Research Colony (VRC). Using a combination automated manual segmentation we quantified several correlated but distinct phenotypes. estimated heritabilities (h(2)) for these in...
Respiratory virus infections in humans cause a broad-spectrum of diseases that result substantial morbidity and mortality annually worldwide. To reduce the global burden respiratory viral diseases, preventative therapeutic interventions are accessible effective urgently needed, especially countries disproportionately affected. Repurposing generic medicine has potential to bring new treatments for infectious patients efficiently equitably. In this study, we found intranasal delivery neomycin,...
Summary Background Biomarkers such as quantitative HBsAg (qHBsAg), hepatitis B virus (HBV) core‐related antigen (qHBcrAg) and HBV RNA may be useful in predicting loss patients with chronic (CHB) undergoing antiviral therapy. Aim(s) Our study evaluated qHBsAg, qHBcrAg a posthoc analysis of randomized clinical trial peginterferon±NA to determine their utility loss. Methods CHB who completed therapy 48weeks peginterferon alpha2b ± nucleoside analogue (clinicaltrial.gov NCT01928511) were at week...
Abstract Current therapeutic options for recurrent neuroblastoma have poor outcomes that warrant the development of novel strategies. Specificity protein (Sp) transcription factors regulate several genes involved in cell proliferation, survival, and angiogenesis. Sp1 regulates believed to be important determinants biological behavior neuroblastoma. Tolfenamic acid (TA), a non‐steroidal anti‐inflammatory drug, is known induce degradation Sp proteins may serve as anti‐cancer agent. The...
Medulloblastoma (MB) is the most common malignancy in children arising brain. Morbidities associated with intensive therapy are serious concerns treating MB. Our aim was to identify novel targets and agents less toxicity for Specificity protein 1 (Sp1) transcription factor regulates several genes involved cell proliferation survival including survivin, an inhibitor of apoptosis protein. We previously showed that tolfenamic acid (TA), a nonsteroidal anti-inflammatory drug, inhibits...
Abstract Host response aimed at eliminating the infecting pathogen, as well pathogen itself, can cause tissue injury. Tissue injury leads to release of a myriad cellular components including mitochondrial DNA, which host senses through pattern recognition receptors. How sensing by shapes anti-pathogen remains poorly understood. In this study, we utilized mice that are deficient in toll-like receptor-9 (TLR9), binds unmethylated CpG DNA sequences such those present bacterial and DNA. To avoid...
Objective: To survey the use by Australian pensioners of orally administered antimicrobial agents supplied through Pharmaceutical Benefits Scheme over years 1987–1989. Data sources: pensioner data for 1987–1989 and market research from a private company. extraction: The were initially available as number prescriptions dispensed aggregated on quarter year basis. These converted to defined daily doses (DDDs) per 1000 day (DDD/1000 day). This conversion allows comparisons across drug groups,...
We aimed to identify the health and quality-of-life research priorities of Australians with diabetes or family members.
We conducted an initial assessment of the biosurveillance capabilities a new software application called Praedico and compared results obtained from previous queries with ESSENCE.
Eosinophilic esophagitis (EoE) is a clinicopathologic condition that characterized by chronic inflammation with variable manifestations.1 Esophageal strictures are one of the fibrotic remodeling features EoE and more commonly seen diagnostic delay.2 Recognition important given their role in complications EoE, such as food impactions, because dilation can safely provide significant symptomatic benefit.3,4 While it has been frequently demonstrated incidence prevalence have increasing, unknown...