A5101439537- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Plant Molecular Biology Research
- Cytomegalovirus and herpesvirus research
- CAR-T cell therapy research
- Histiocytic Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Influenza Virus Research Studies
- Glioma Diagnosis and Treatment
- Acute Ischemic Stroke Management
- RNA Research and Splicing
- Immune Response and Inflammation
- Lung Cancer Treatments and Mutations
- Systemic Lupus Erythematosus Research
- Respiratory viral infections research
- Colorectal Cancer Treatments and Studies
- Pancreatitis Pathology and Treatment
- Endometrial and Cervical Cancer Treatments
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
University of Pittsburgh Medical Center
2024-2025
UCSF Helen Diller Family Comprehensive Cancer Center
2017-2024
University of California, San Francisco
2017-2024
National Cancer Institute
2003-2024
University of Utah
2024
University Health Network
2024
University of Toronto
2024
Center for Cancer Research
2005-2024
University of Pittsburgh
2024
Dana-Farber Cancer Institute
2024
Background. Kaposi sarcoma-associated herpesvirus (KSHV) is the causal agent for sarcoma (KS) and multicentric Castleman disease (MCD) in human immunodeficiency virus (HIV)-infected patients. Patients with KSHV-MCD develop fevers, wasting, hypoalbuminemia, cytopenias, hyponatremia that are related to overproduction of KSHV-encoded viral interleukin (IL)-6 (vIL-6) IL-6 (hIL-6).
Background. Kaposi sarcoma herpesvirus (KSHV) is the cause of (KS), primary effusion lymphoma (PEL), and a form Castleman disease (KSHV-MCD). Recently KSHV-associated inflammatory cytokine syndrome (KICS) distinct from KSHV-MCD was reported.
Abstract Cells exposed to hypoxia respond by increasing the level of hypoxia-inducible factor-1 (HIF-1). This factor then activates a number genes binding response elements in their promoter regions. A second hypoxia-responsive factor, HIF-2, can activate many same as HIF-1. Overexpression HIFs accompanies pathogenesis tumors. It is unclear, however, respective role these factors responsiveness and other stresses. To address this issue, we used microarray technology study activated HEK293T...
Fibroblast activation protein (FAP), expressed in the tumor microenvironment of a variety cancers, has become target novel PET tracers. The purpose this report is to evaluate imaging characteristics <sup>68</sup>Ga-FAP-2286, present first—to our knowledge—dosimetry analysis date, and compare agent with <sup>18</sup>F-FDG FAPI compounds. <b>Methods:</b> Patients were administered 219 ± 43 MBq <sup>68</sup>Ga-FAP-2286 scanned after 60 min. Uptake was measured up 5 lesions per patient within...
COVID-19 pandemic has infected more than 154 million people worldwide and caused 3.2 deaths. It is transmitted by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) affects respiratory tract as well extra-pulmonary systems, including pancreas, that express virus entry receptor, Angiotensin-Converting Enzyme (ACE2) receptor. Importantly, endocrine exocrine latter composed of ductal acinar cells, high levels ACE2, which correlates to impaired functionality characterized acute...
Kaposi's sarcoma (KS)-associated herpesvirus (KSHV), also known as human 8, is an etiologic agent of KS, primary effusion lymphoma (PEL), and multicentric Castleman's disease. We recently demonstrated that hypoxia can induce lytic replication KSHV in PEL cell lines. Hypoxia induces the accumulation hypoxia-inducible factors (HIF), we hypothesized genome may respond to through functional response elements (HREs). Here, demonstrate presence at least two promoters within are activated by or...
The Liver X receptor (LXR) is an important regulator of carbohydrate and lipid metabolism in humans mice. We have recently shown that activation LXR regulates cellular fuel utilization adipocytes. In contrast, the role human adipocyte lipolysis, major function white fat cells, not clear. present study, we stimulated vitro differentiated murine adipocytes with agonist GW3965 observed increase basal lipolysis. Microarray analysis mRNA following revealed altered gene expression several...
Host response aimed at eliminating the infecting pathogen, as well pathogen itself, can cause tissue injury. Tissue injury leads to release of a myriad cellular components including mitochondrial DNA, which host senses through pattern recognition receptors. How sensing by shapes anti-pathogen remains poorly understood. In this study, we utilized mice that are deficient in toll-like receptor-9 (TLR9), binds unmethylated CpG DNA sequences such those present bacterial and DNA. To avoid direct...
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent for sarcoma (KS) and primary effusion lymphoma (PEL). We previously reported that hypoxia activates KSHV lytic replication promoter open reading frame 34 (ORF34) contains a functional hypoxia-responsive element (HRE). ORF34 part of cluster genes (ORF34-37) includes ORF36, phosphotransferase, ORF37, shutoff exonuclease. Rapid amplification cDNA ends analysis revealed they share common polyadenylation signal but have two...
// David A. Davis 1,* , Suraj Mishra Holda Anagho 1 Ashley I. Aisabor Prabha Shrestha Victoria Wang Yuki Takamatsu Kenji Maeda Hiroaki Mitsuya Jerome B. Zeldis 2 and Robert Yarchoan HIV AIDS Malignancy Branch, Center for Cancer Research, National Institute, Bethesda, MD, USA Celgene Corp., Summit, NJ, * These authors have contributed equally to this study Correspondence to: Davis, email: Keywords : Kaposi sarcoma-associated herpesvirus, pomalidomide, lenalidomide, major histocompatibility...
Background Direct acting oral anticoagulants ( DOAC s) theoretically could contribute to addressing underuse of anticoagulation in non‐valvular atrial fibrillation NVAF ). Few studies have examined this prospect, however. The potential s address be magnified within a healthcare system that sharply limits patients’ exposure out‐of‐pocket copayments, such as the Veterans Health Administration VA Methods and Results We used clinical data set all patients with treated from 2007 2016 (n=987 373)....
ABSTRACT Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent for Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and a subset of multicentric Castleman disease (MCD). The KSHV life cycle has two principal gene repertoires, latent lytic. viral interleukin-6 (vIL-6), an analog human IL-6, usually lytic; production vIL-6 by involved plasmablasts central feature KSHV-MCD. also plays role in PEL KS. We show that number from lymph nodes patients with KSHV-MCD express but...
DNA mismatch repair is of considerable scientific and medical importance because its essential role in maintaining genomic integrity, association with hereditary non-polyposis colon cancer (HNPCC). Germline mutations five genes (MLH1, MSH2, PMS1, PMS2, MSH6) have been associated HNPCC susceptibility. Our laboratory recently identified MLH3, a novel gene. We screened the MLH3 coding sequence 60 probands increased genetic risk factors for colorectal susceptibility no other candidate genes. No...