A5062715617- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Virology and Viral Diseases
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- Adipose Tissue and Metabolism
- Long-Term Effects of COVID-19
- Viral-associated cancers and disorders
- Sirtuins and Resveratrol in Medicine
- Viral gastroenteritis research and epidemiology
- Diet and metabolism studies
- SARS-CoV-2 detection and testing
- Gut microbiota and health
- vaccines and immunoinformatics approaches
- Cytomegalovirus and herpesvirus research
- Muscle metabolism and nutrition
- Immunotoxicology and immune responses
- Exercise and Physiological Responses
- Lymphoma Diagnosis and Treatment
- Viral Infections and Vectors
- Reproductive Physiology in Livestock
- Viral Infections and Immunology Research
- Calcium signaling and nucleotide metabolism
- Cardiovascular Disease and Adiposity
Avalon University School of Medicine
2025
Central Food Technological Research Institute
2003-2024
University of Aruba
2024
Council of Scientific and Industrial Research
2020-2023
Mysore Medical College
2022
Ministry of Science, Technology and Innovation
2022
Academy of Scientific and Innovative Research
2021-2022
Pakistan Council of Scientific & Industrial Research
2021
Analysis and Testing Centre
2021
Indian Veterinary Research Institute
2007-2017
Since the discovery of NAD-dependent deacetylases, sirtuins, it has been recognized that maintaining intracellular levels NAD is crucial for management stress response cells. Here we show agonist-induced cardiac hypertrophy associated with loss NAD, but not exercise-induced physiologic hypertrophy. Exogenous addition was capable and blocking hypertrophic in vitro as well vivo. treatment blocked activation pro-hypertrophic Akt1 signaling, augmented activity anti-hypertrophic LKB1-AMPK...
Abstract In the long term, diabetes profoundly affects multiple organs, such as kidney, heart, brain, liver, and eyes. The gradual loss of function in these vital organs contributes to mortality. Nonetheless, effects on lung tissue are not well understood. Clinical experimental data from our studies revealed that induces inflammatory fibrotic changes lung. These were mediated by TGF-β-activated epithelial-to-mesenchymal transition (EMT) signaling pathways. Our also found glucose restriction...
Chronic activation of stress hormones such as glucocorticoids leads to skeletal muscle wasting in mammals. However, the molecular events that mediate glucocorticoid-induced are not well understood. Here, we show SIRT6, a chromatin-associated deacetylase indirectly regulates by modulating IGF/PI3K/AKT signaling. Our results SIRT6 levels increased during reduction myotube size and atrophy mice. Notably, overexpression spontaneously decreases primary myotubes cell-autonomous manner. On other...
Amyotrophic lateral sclerosis (ALS) is a multi-systemic, incurable, amyloid disease affecting the motor neurons, resulting in death of patients. The either sporadic or familial with SOD1, C9orf72, FUS, and TDP-43 constituting majority ALS. Multi-omics studies on patients model systems like mice yeast have helped understanding association various signaling metabolic pathways disease. system has played pivotal role elucidating gene interactions. We carried out an integrated transcriptomic...
Primary effusion lymphoma (PEL) is an aggressive B-cell with poor prognosis caused by Kaposi's sarcoma-associated herpesvirus (KSHV). Previous studies have revealed that HIF-1α, which mediates much of the cellular response to hypoxia, plays important role in life cycle KSHV. KSHV infection promotes HIF-1α activity, and several genes are turn activated HIF-1α. In this study, we investigated effects knocking down PELs. We observed knockdown each two PEL lines leads a reduction both aerobic...
ABSTRACT Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent for Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and a subset of multicentric Castleman disease (MCD). The KSHV life cycle has two principal gene repertoires, latent lytic. viral interleukin-6 (vIL-6), an analog human IL-6, usually lytic; production vIL-6 by involved plasmablasts central feature KSHV-MCD. also plays role in PEL KS. We show that number from lymph nodes patients with KSHV-MCD express but...
To understand the spread of SARS-CoV2, in August and September 2020, Council Scientific Industrial Research (India) conducted a serosurvey across its constituent laboratories centers India. Of 10,427 volunteers, 1058 (10.14%) tested positive for SARS-CoV2 anti-nucleocapsid (anti-NC) antibodies, 95% which had surrogate neutralization activity. Three-fourth these recalled no symptoms. Repeat serology tests at 3 (n = 607) 6 175) months showed stable anti-NC antibodies but declining Local...
ABSTRACT Brucella melitensis is a highly infectious zoonotic pathogen responsible for brucellosis, which significantly affects both human and livestock health worldwide. This study employed whole-genome sequencing (WGS) to analyze the genetic diversity of 24 B. isolates from India. Pangenome analysis revealed conserved nature with involved strains having very limited accessory genes. Multilocus Sequence Typing (MLST) identified sequence type ST8 as predominant among Indian strains. Analysis...
ABSTRACT Hypoxia and hypoxia-inducible factors (HIFs) play an important role in the Kaposi's sarcoma-associated herpesvirus (KSHV) life cycle. In particular, hypoxia can activate lytic replication of KSHV specific genes, including transcription activator (RTA), while infection turn increase levels activity HIFs. present study, we show that increases mRNAs encoding latency-associated nuclear antigen (LANA) primary effusion lymphoma (PEL) cell lines also LANA protein. Luciferase reporter...
Data science has been an invaluable part of the COVID-19 pandemic response with multiple applications, ranging from tracking viral evolution to understanding vaccine effectiveness. Asymptomatic breakthrough infections have a major problem in assessing effectiveness populations globally. Serological discrimination infection so far limited Spike protein vaccines since whole virion generate antibodies against all proteins. Here, we show how statistical and machine learning (ML) based approach...
Hypoxia inducible factors (HIFs) are the principal means by which cells upregulate genes in response to hypoxia and certain other stresses. There two major HIFs, HIF-1 HIF-2. We previously found that preferentially activated One was protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1). PTPRZ1 is overexpressed a number of tumors has been implicated glioblastoma pathogenesis.To understand preferential activation HIF-2, we studied promoter HEK293T Hep3B cells. Through deletion...