A5083687186- Management of metastatic bone disease
- Lymphoma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- CAR-T cell therapy research
- CNS Lymphoma Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Brain Metastases and Treatment
- Radiopharmaceutical Chemistry and Applications
- Spine and Intervertebral Disc Pathology
- Glioma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Radiation Dose and Imaging
- Spinal Fractures and Fixation Techniques
- Sarcoma Diagnosis and Treatment
- Radiology practices and education
- Chronic Lymphocytic Leukemia Research
- Cutaneous lymphoproliferative disorders research
- Economic and Financial Impacts of Cancer
- Lung Cancer Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Polyomavirus and related diseases
- Effects of Radiation Exposure
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
The University of Texas Southwestern Medical Center
2019-2025
Stanford University
2015-2024
Southwestern Medical Center
2019-2024
Dana-Farber Cancer Institute
2021-2023
Harold C. Simmons Comprehensive Cancer Center
2022
Indian Institute of Chemical Technology
2021
Broad Institute
2020
Cancer Institute (WIA)
2017-2020
Stanford Cancer Institute
2017-2019
Northwestern University
2018
Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of lymphoproliferative disorders arising from mature T cells, accounting for about 10% non-Hodgkin lymphomas. PTCL-not otherwise specified is the most common subtype, followed by angioimmunoblastic lymphoma, anaplastic large cell lymphoma kinase–positive, kinase–negative, and enteropathy-associated lymphoma. This discussion section focuses on diagnosis treatment PTCLs as outlined in NCCN Guidelines T-Cell Lymphomas.
Significance An undesirable outcome of radiotherapy (ionizing radiation, IR) cancer is the emergence radioresistant cells. We report that Laboratory Genetics and Physiology 2 (LGP2), a resident RIG-I (retinoic acid inducible gene I)–like receptor protein, can induce radioresistance. IR induces interferon stimulates accumulation LGP2. In turn, LGP2 shuts off synthesis blocks its cytotoxic effects. Ectopic expression enhances resistance to IR, whereas depletion effects IR. Here we show...
Abstract Background Advanced radiotherapeutic treatment techniques limit the cognitive morbidity associated with whole-brain radiotherapy (WBRT) for brain metastasis through avoidance of hippocampal structures. However, achieving durable intracranial control remains challenging. Methods We conducted a single-institution single-arm phase II trial hippocampal-sparing whole irradiation simultaneous integrated boost (HSIB-WBRT) to metastatic deposits in adult patients metastasis. Radiation...
Anaplastic sarcoma of the kidney (ASK) is a DICER1-related neoplasm first identified as distinctive tumor type through evaluation unusual cases putative anaplastic Wilms tumors. Subsequent case reports presence biallelic DICER1 variants well progression from cystic nephroma, benign neoplasm. Despite increasing recognition ASK distinct entity, optimal treatment remains unclear.
Purpose: Dynamic contrast-enhanced magnetic resonance imaging offers noninvasive characterization of the vascular microenvironment and hemodynamics. Stereotactic radiosurgery, or stereotactic body radiation therapy, engages a component tumor response which may be detectable using dynamic imaging. The purpose this study is to examine whether can used predict local recurrence in patients with spinal bone metastases who undergo high-dose radiotherapy radiosurgery. Materials Methods: We...
Since Wolpe (1958) developed the idea of psychotherapy by reciprocal inhibition, systematic desensitization has emerged as an effective method treatment in phobic states. There exists, however, a group phobias which cannot be effectively treated with these techniques. These include fears death, illness, harming other people, etc., and have been recognized authors separate themselves (Marks et al., 1969; Marks, 1969, 1970): internal stimuli. The search for suitable to treat cases led us use...
Total body irradiation is an important part of the conditioning regimens frequently used to prepare patients for allogeneic hematopoietic stem cell transplantation (SCT). Volumetric-modulated arc therapy enabled total (VMAT-TBI), alternative conventional TBI (cTBI), a novel radiotherapy treatment technique that has been implemented and investigated in our institution. The purpose this study (1) report six-year clinical experience terms planning strategy delivery time (2) evaluate outcomes...
To understand the spread of SARS-CoV2, in August and September 2020, Council Scientific Industrial Research (India) conducted a serosurvey across its constituent laboratories centers India. Of 10,427 volunteers, 1058 (10.14%) tested positive for SARS-CoV2 anti-nucleocapsid (anti-NC) antibodies, 95% which had surrogate neutralization activity. Three-fourth these recalled no symptoms. Repeat serology tests at 3 (n = 607) 6 175) months showed stable anti-NC antibodies but declining Local...
This research completely investigates the net effect of mergers and acquisitions (M&A) by each multinational company (MNC) from perspectives many students studying Master Business Administration (MBA). It thoroughly examines how MBA precisely view different consequences M&A activity as it considers their particular effects on organizational culture along with staff morale, competition in marketplace, addition to shareholders' value. study extensively explores degree student...
ABSTRACT Background Sézary syndrome (SS) is a rare and aggressive leukemic variant of cutaneous T-cell lymphoma (CTCL) with limited therapeutic options median survival fewer than five years. Despite advances in how single-cell RNA sequencing (scRNA-seq) has improved the understanding treatment other cancer types, such insights SS remain limited. The drivers disease progression immunologic dysfunction are incompletely defined, underscoring need to characterize both malignant T cells (MTCs)...
Abstract BACKGROUND Stereotactic radiosurgery (SRS) for benign intracranial tumors is an established standard of care. The widespread implementation SRS spinal has been limited by lack long-term data. OBJECTIVE To update our institutional experience safety and efficacy outcomes after tumors. METHODS We performed a retrospective cohort study 120 patients with 149 (39 meningiomas, 26 neurofibromas, 84 schwannomas) treated between 1999 2016, follow-up magnetic resonance imaging available...
Colorectal cancer (CRC) and other gastrointestinal (GI) cancers are believed to have greater radioresistance than histologies. The authors report local control toxicity outcomes of stereotactic radiosurgery (SRS) spinal metastases from GI primary cancers.
The addition of procarbazine, lomustine, vincristine (PCV) chemotherapy to radiotherapy (RT) for patients with high-risk (≥40 y old or subtotally resected) low-grade glioma (LGG) results in an absolute median survival benefit over 5 years. We evaluated the cost-effectiveness this treatment strategy.A decision tree integrated 3-state Markov model was created follow LGG after surgery treated RT versus RT+PCV. Patients existed one 3 health states: stable, progressive, dead. Survival and freedom...
This practice parameter was revised collaboratively by the American College of Radiology (ACR) and Radium Society (ARS). provides updated reference literature regarding both clinical-based conventional total body irradiation evolving volumetric modulated irradiation.This developed according to process described under heading The Process for Developing ACR Practice Parameters Technical Standards on website ( https://www.acr.org/Clinical-Resources/Practice-Parameters-and-Technical-Standards )...