A5011396539- Health and Wellbeing Research
- COVID-19 and Mental Health
- Workplace Violence and Bullying
- Healthcare professionals’ stress and burnout
- Geriatric Care and Nursing Homes
- Intergenerational Family Dynamics and Caregiving
- Health disparities and outcomes
- Job Satisfaction and Organizational Behavior
- Tissue Engineering and Regenerative Medicine
- Primary Care and Health Outcomes
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- Mesenchymal stem cell research
- Chronic Disease Management Strategies
- Nursing education and management
- Resilience and Mental Health
- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- Diabetes Management and Research
- Workplace Health and Well-being
- Immune Cell Function and Interaction
- Adipose Tissue and Metabolism
- Healthcare Policy and Management
- Occupational Health and Safety Research
- Diabetes Management and Education
Huazhong University of Science and Technology
2022-2025
Xinxiang Medical University
2025
Sichuan University
2020-2024
Northwest Institute of Nuclear Technology
2024
Union Hospital
2022-2024
University of Alabama at Birmingham
2023
Science and Technology Department of Sichuan Province
2023
Wuhan Union Hospital
2022
Nanjing University
2022
West China Medical Center of Sichuan University
2022
Emerging evidence indicates that ionizing radiation (IR) and chemotherapy activate Type I interferon (IFN) signaling in tumor host cells. However, the mechanism of induction is poorly understood. We identified a novel radioprotective role for DEXH box RNA helicase LGP2 (DHX58) through its suppression IR-induced cytotoxic IFN-beta [1]. inhibits activation RIG-I-like receptor (RLR) pathway upon binding viral to cytoplasmic sensors RIG-I (DDX58) MDA5 (IFIH1) subsequent IFN via mitochondrial...
BACKGROUND:A growing body of evidence suggests that in the face life adversity, threats, or other major stressful events, resilience is more conducive to individual adaptation and growth. MATERIAL AND METHODS:The Connor-Davidson Resilience Scale Chinese Perceived Stress were used evaluate perceived stress 600 medical staff members from radiology departments 32 public hospitals Sichuan Province, China, respectively. Multiple linear regression was analyze factors related resilience....
BACKGROUND:During the outbreak of COVID-19, health care workers in radiology department frequently interact with suspected patients and face a higher risk infection sudden surges workload. High anxiety levels seriously harm physical mental affect work efficiency patient safety. Therefore, it is critical to determine explore its factors. MATERIAL AND METHODS:Self-Rating Anxiety Scale Connor-Davidson Resilience were used evaluate resilience 364 high exposure from departments 32 public...
Significance An undesirable outcome of radiotherapy (ionizing radiation, IR) cancer is the emergence radioresistant cells. We report that Laboratory Genetics and Physiology 2 (LGP2), a resident RIG-I (retinoic acid inducible gene I)–like receptor protein, can induce radioresistance. IR induces interferon stimulates accumulation LGP2. In turn, LGP2 shuts off synthesis blocks its cytotoxic effects. Ectopic expression enhances resistance to IR, whereas depletion effects IR. Here we show...
Pandemic COVID-19 by severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) infection is facilitated the ACE2 receptor and protease TMPRSS2. Modestly sized case series have described clinical factors associated with COVID-19, while TMPRSS2 expression analyses been in some cell types. Patients cancer may worse outcomes to COVID-19.We performed an integrated study of gene across within organ systems, normal versus tumor, several existing databases (The Cancer Genome Atlas, Census...
This study aimed to develop a theoretical model of caring leadership in nursing.
Previous studies have established a positive link between nurse managers' caring leadership and nurses' work engagement, but the processes conditions through which this style influences behaviors remain largely unexplored. To address gap contribute to existing body of knowledge, we developed chain-mediated effects model elucidate impact on engagement underlying mechanisms. In model, identified professional mission affective organizational commitment as mediating variables, offering novel...
A bstract Aims To explore the association between nurse managers' paternalistic leadership and nurses' perceived workplace bullying (WPB), as well to examine mediating role of organizational climate in this association. Background There is a lack empirical evidence regarding relationship leadership, WPB. Clarifying crucial understand how influences WPB for nursing managers seek organizational‐level solutions prevent it. Methods cross‐sectional survey was performed from 4 January 10 February...
Environmental endocrine disruptors are implicated as putative contributors to the burgeoning metabolic disease epidemic. Tolylfluanid (TF) is a commonly detected fungicide in Europe, and previous vitro ex vivo work has identified it potent disruptor with capacity promote adipocyte differentiation induce adipocytic insulin resistance, effects likely resulting from activation of glucocorticoid receptor signaling. The present study extends these findings an mouse model dietary TF exposure....
With the growing challenge of an aging population, addressing needs elderly individuals who face living difficulties and lack family support becomes increasingly difficult. Volunteer services are crucial in this context, yet their effectiveness is hindered by unclear service scopes uncertain volunteer inclinations.
The care requirements of the elderly who live at home should receive enough attention as world's population ages. On basis this, a questionnaire on must be created and validated. objective is to create validate tool that will allow caregivers more accurately measure how well-cared-for people perceive them home. This study developed caring perception through literature review interviews in Wuhan. Fifteen experts from six provinces reviewed initial 43-item draft. When faulty questionnaires...
With the acceleration of population aging, it becomes increasingly difficult to meet complex needs older adults living in communities. Although volunteering is an important resource addressing aging crisis, lack clear motivations and finely-tuned strategic guidance present obstacles. This study aims understand strategies involved voluntary service for urban home-based provided by volunteers with a nursing background. A qualitative descriptive design was adopted. Twenty-three background were...
This study aimed to assess quality care behavior among nursing assistants and investigate potential influencing pathways based on the capability opportunity motivation-behavior (COM–B) model. Nursing are frontline staff responsible for most residents' daily care, their behaviors closely associated with of life. A cross-sectional research methodology was implemented, data were collected demographic sociological information, assistants' behaviors, knowledge skills, attitude toward older...
Peptide-based neoantigen vaccines are promising cancer immunotherapy strategies because of their capability to induce durable tumor-specific immune responses. However, insufficient neoantigen-specific T-lymphocyte activation greatly limits clinical efficacy. Here, we developed sericin-coordinated zinc ion-modified calcium phosphate (CP) nanovaccines that codeliver tumor antigen peptides and a Toll-like receptor 9 agonist (SZCP/APs-CpG) for potentiating antigen-specific T cell immunity....
The various complex needs for assistance among home-based older adults have increased dramatically. Thus, it would be advantageous to recruit volunteers with medical knowledge and a better understanding support assist the elderly living in urban communities.This study aimed explore experiences expectations of receiving volunteer services Chinese areas. DESIGN, SETTING AND PARTICIPANTS: A descriptive qualitative was conducted following Consolidated Criteria Reporting Qualitative Research...
During the COVID-19 pandemic, nurses' workload increased dramatically, and nurses faced risk of infection multiple ethical dilemmas. In such a situation, nurse burnout was elevated, which tended to exacerbate depression in nurses. Although previous studies have demonstrated relationship between among nurses, exact mechanisms remain unclear. Furthermore, environmental factors are also essential person's psychological health. Therefore, this study intended investigate potential caused by...
Preventing Chronic Disease (PCD) is a peer-reviewed electronic journal established by the National Center for Prevention and Health Promotion. PCD provides an open exchange of information knowledge among researchers, practitioners, policy makers, others who strive to improve health public through chronic disease prevention.
Abstract Aim To identify determinants of family cohesion and adaptability among Chinese registered nurses. Background In China, the shortage nurses imposes a higher physical emotional workload, which will aggravate their work–family conflicts. Therefore, it is easy for to ignore importance family, undeniably detrimental healthy self‐development providing better care patients. Design With cross‐sectional observational study design (see STROBE checklist Supplementary File 1). Methods The...
Among nonelderly adults with diabetes, we compared hospitalizations for ambulatory care–sensitive conditions from 2013 (pre-Medicaid expansion) and 2014 (post-Medicaid 13 expansion 4 nonexpansion states using State Inpatient Databases. Medicaid was associated decreases in proportions of chronic (difference between −0.17 percentage points 0.37 states, P = .04), specifically diabetes short-term complications −0.05 0.21 .04). Increased access to care through may improve disease management diabetes.
Abstract Background With the development of social economy, effective coordination conflict between work and family has become an urgent problem for most parents. Such conflicts are especially acute in families nurses with children. Therefore, a timely understanding status quo parent-child relationship associated risk factors among will assist improving their harmony healthy growth Methods A total 350 children at general tertiary hospital Sichuan Province, China, were interviewed using...