A5072610753- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Head and Neck Surgical Oncology
- RNA modifications and cancer
- Tumors and Oncological Cases
- Epigenetics and DNA Methylation
- Oral and Maxillofacial Pathology
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Cancer Genomics and Diagnostics
- Neuroblastoma Research and Treatments
- Clusterin in disease pathology
- Cancer Immunotherapy and Biomarkers
- Machine Learning in Bioinformatics
- Molecular Biology Techniques and Applications
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Cervical Cancer and HPV Research
- Cancer Research and Treatments
- Cytokine Signaling Pathways and Interactions
- Genetic factors in colorectal cancer
- Ferroptosis and cancer prognosis
- Radiopharmaceutical Chemistry and Applications
University of California, San Francisco
2016-2025
National Hospital for Neurology and Neurosurgery
2025
University College London
2025
UCSF Helen Diller Family Comprehensive Cancer Center
2018-2024
University of California San Francisco Medical Center
2019-2024
Western Health
2023
University of California, San Diego
2023
Institut de Virologie
2020-2021
John Wiley & Sons (United States)
2016-2021
Hudson Institute
2019-2021
Tumor DNA in saliva and plasma can provide a noninvasive biomarker for head neck squamous cell carcinoma.
PURPOSE To provide evidence-based recommendations for practicing physicians and other healthcare providers on the management of salivary gland malignancy. METHODS ASCO convened an Expert Panel medical oncology, surgical radiation neuroradiology, pathology, patient advocacy experts to conduct a literature search, which included systematic reviews, meta-analyses, randomized controlled trials, prospective retrospective comparative observational studies published from 2000 through 2020. Outcomes...
CD8
BACKGROUND Human papillomavirus (HPV) is a well‐established prognostic marker for oropharyngeal squamous cell cancer (OPSCC). Because of the limited numbers women and nonwhites in studies to date, sex racial/ethnic differences prognosis have not been well explored. In this study, survival were explored by tumor HPV status among 1) patients with OPSCCs race 2) nonoropharyngeal (non‐OP) head neck cancers (HNSCCs). METHODS This retrospective, multi‐institution study included non‐OP HNSCCs oral...
BACKGROUND. Adenoid cystic carcinoma (ACC) is a rare malignancy arising in salivary glands and other sites, characterized by high rates of relapse distant spread. Recurrent/metastatic (R/M) ACCs are generally incurable, due to lack active systemic therapies. To improve outcomes, deeper understanding genetic alterations vulnerabilities R/M tumors needed.
Abstract Background Recurrent head and neck squamous cell carcinoma (rHNSCC) represents a significant global health burden with an unmet medical need. In this study we determined the safety efficacy of RM‐1929 photoimmunotherapy in patients heavily pretreated rHNSCC. Methods (anti‐EGFR–IR700 dye conjugate) was infused, followed by tumor illumination. We evaluated safety, response, pharmacokinetics. Results Nine were enrolled Part 1 (dose‐finding) 30 2 (safety efficacy). No dose‐limiting...
Cancer of the pancreas is a genetic disease. Sporadic cancers are frequently associated with activation an oncogene, K-ras, and inactivation multiple tumor suppressor genes, including p53, DPC4, p16, BRCA2. An improved understanding genetics cancer should lead to new tests screen for this disease novel rational gene-based therapies.
Abstract Purpose: Mitochondria are highly susceptible to oxidative damage. Although mitochondrial function decreases with damage, overall DNA (mtDNA) content increases compensate for general dysfunction. We performed quantitative polymerase chain reaction genes specific and nuclear genomes investigate relative abundance in a spectrum of dysplastic head neck lesions. Experimental Design: from mild, moderate, severe dysplasias, as well invasive tumors normal mucosal cells, was extracted. Using...
Abstract Purpose: To determine if phosphodiesterase 5 (PDE5) inhibitors can augment immune function in patients with head and neck cancer through inhibition of myeloid-derived suppressor cells (MDSC). Experimental Design: We performed a randomized, prospective, double blinded, placebo controlled, phase II clinical trial to the vivo effects systemic PDE5 on squamous cell carcinoma (HNSCC). Results: Tadalafil augmented response, increasing ex T-cell expansion mean 2.4-fold increase compared...
BACKGROUND The incidence of oropharyngeal squamous cell carcinoma (OPSCC) is increasing among older adults. It unknown whether these trends can be explained by human papillomavirus (HPV) and HPV‐related tumors remain associated with an improved prognosis patients. METHODS In a retrospective study OPSCCs diagnosed from 1995 to 2013 at 2 National Comprehensive Cancer Network–designated cancer centers, p16 immunohistochemistry in situ hybridization (ISH) for HPV‐16, high‐risk DNA, and/or E6/E7...
Human papillomavirus (HPV) causes an increasing proportion of oropharyngeal squamous cell carcinomas (OPSCCs), particularly in white men. The prevalence HPV among other demographic groups and anatomic sites HNSCC is unclear.To explore the role tumor status women nonwhites with OPSCC patients nonoropharyngeal head neck carcinoma (non-OP HNSCC).Retrospective cohort study at 2 tertiary academic centers including cases diagnosed 1995 through 2012, oversampled for minorities females. A stratified...
Human papillomavirus (HPV) tumor status and surgical salvage are associated with improved prognosis for patients recurrent oropharyngeal squamous cell carcinoma (OPSCC). Current data regarding types of surgery the impact distant metastatic disease limited.A retrospective analysis OPSCC from 2 institutions between 2000 2012 was performed. p16 immunohistochemistry and/or in situ hybridization, as clinically available, were used to determine HPV status. Clinical characteristics, distribution...
Adenoid cystic carcinomas (ACC) of the salivary glands are challenging to understand, treat, and cure. To better understand genetic alterations underlying pathogenesis these tumors, we performed comprehensive genome analyses 25 fresh-frozen including whole-genome sequencing expression pathway analyses. In addition well-described MYB-NFIB fusion that was found in 11 tumors (44%), observed five different rearrangements involving NFIB transcription factor gene seven (28%). Taken together,...
Although promoter-associated CpG islands have been established as targets of DNA methylation changes in cancer, previous studies suggest that epigenetic dysregulation outside the promoter region may be more closely associated with transcriptional changes. Here we examine methylation, chromatin marks, and alterations to define relationship between modulation spatial structure. Using human papillomavirus-related oropharyngeal carcinoma a model, show aberrant enrichment repressive H3K9me3 at...
Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. To explore genetic origins of MEC, we performed systematic genomic analyses these tumors.Whole-exome sequencing and gene copy-number were for 18 primary cancers with matched normal tissue. FISH was used to determine presence or absence MECT1-MAML2 translocation in 17 tumors.TP53 commonly mutated MEC (28%), mutations found only intermediate- high-grade tumors. Tumors TP53 had more overall than tumors without (P =...
Abstract Purpose: Following cytotoxic therapy, 70% of patients with human papillomavirus (HPV)-positive oropharyngeal head and neck squamous cell carcinoma (HNSCC) are alive at 5 years compared 30% those similar HPV-negative cancer. Loss TGFβ signaling is a poorly studied consequence HPV that could contribute to patient outcome by compromising DNA repair. Experimental Design: Human HNSCC lines (n = 9), patient-derived xenografts tissue microarray 194), TCGA expression data 279), primary...
Fibroblast activation protein (FAP), expressed in the tumor microenvironment of a variety cancers, has become target novel PET tracers. The purpose this report is to evaluate imaging characteristics <sup>68</sup>Ga-FAP-2286, present first—to our knowledge—dosimetry analysis date, and compare agent with <sup>18</sup>F-FDG FAPI compounds. <b>Methods:</b> Patients were administered 219 ± 43 MBq <sup>68</sup>Ga-FAP-2286 scanned after 60 min. Uptake was measured up 5 lesions per patient within...