A5102741953- Neuroinflammation and Neurodegeneration Mechanisms
- Single-cell and spatial transcriptomics
- Genetics and Neurodevelopmental Disorders
- RNA regulation and disease
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
- Immune cells in cancer
- Neuropeptides and Animal Physiology
- Restraint-Related Deaths
- Folate and B Vitamins Research
- Pain Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Plant Molecular Biology Research
- Nuclear Receptors and Signaling
- Fungal Biology and Applications
- Neurogenetic and Muscular Disorders Research
- Plant Stress Responses and Tolerance
- Protein Kinase Regulation and GTPase Signaling
- Muscle Physiology and Disorders
- Receptor Mechanisms and Signaling
- Spinal Cord Injury Research
- Mesenchymal stem cell research
- Cancer Immunotherapy and Biomarkers
- Neuroscience of respiration and sleep
University of California, Los Angeles
2020-2024
Sichuan University
2021-2023
West China Hospital of Sichuan University
2021-2023
California Northstate University
2022-2023
University of California System
2016
University of the Pacific
2014
University of California, Davis
2013-2014
Carnegie Institution for Science
2014
Carnegie Department of Plant Biology
2014
Palo Alto University
2014
Abstract The trade-off between growth and immunity is crucial for survival in plants. However, the mechanism underlying growth-immunity balance has remained elusive. PRE-IBH1-HBI1 tripartite helix-loop-helix/basic helix-loop-helix module part of a central transcription network that mediates regulation by several hormonal environmental signals. Here, genome-wide analyses HBI1 target genes show regulates both overlapping unique targets compared with other DNA binding components Arabidopsis...
To understand how neural-immune-associated genes and pathways contribute to neurodegenerative disease pathophysiology, we performed a systematic functional genomic analysis in purified microglia bulk tissue from mouse human AD, FTD, PSP. We uncover complex temporal trajectory of microglial-immune involving the type 1 interferon response associated with tau pathology early stages, followed by later signatures partial immune suppression and, subsequently, 2 response. find that genetic risk for...
Abstract Genetic risk for psychiatric disorders lies largely within non-coding regions, where the lack of detailed knowledge gene regulation and chromatin structure has hampered understanding disease mechanisms. We analyzed accessibility 3D genome architecture in brains from 53 ASD neurotypical individuals, including patients with (dup) 15q11-13. observed reduced CTCF binding, which had dual effects: a) decreased at distal enhancers downregulation synaptic neuronal target genes, b) weakened...
Depression, the most common type of mental illness, is second leading cause disability and increasing among Americans. The effect improved nutrition, particularly with dietary supplements, on depression may provide an alternative to standard medical treatment. Some studies have shown that certain nutrients (e.g., inositol S-adenosyl methionine) are effective at improving depressed mood, although results not unequivocal. current study was a randomized, double-blind, placebo-controlled trial...
The development of successful therapeutics for dementias requires an understanding their shared and distinct molecular features in the human brain. We performed single-nuclear RNAseq ATACseq Alzheimer disease (AD), Frontotemporal degeneration (FTD), Progressive Supranuclear Palsy (PSP), analyzing 40 participants, yielding over 1.4M cells from three brain regions ranging vulnerability pathological burden. identify 35 disease-associated cell types 14 that are disease-specific, replicating...
Zipper-interacting protein kinase (ZIPK) is a conserved vertebrate-specific regulator of actomyosin contractility in smooth muscle and non-muscle cells. Murine ZIPK has undergone an unusual divergence sequence regulation compared to other orthologs. In humans, subcellular localization controlled by phosphorylation threonines 299 300. contrast, mouse rat interaction with PAR-4. We carried out comparative biochemical characterization the zebrafish ortholog ZIPK. Like human orthologs undergoes...
Abstract Background Progressive supranuclear palsy (PSP) is a neurodegenerative disorder involving pathological deposition of tau that includes glial inclusions and specific regional vulnerability patterns. Therapeutic developments are hampered by incomplete understanding disease mechanisms. Few studies have examined its cell type‐specific effects. We performed RNA‐sequencing in large cohort PSP patients controls to understand molecular pathways disrupted across prefrontal cortex caudate...
OBJECTIVE: To evaluate the electrophysiological effects of chronic memantine therapy with cognitive ERPs related to language and memory.