A5001873561- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Medical Imaging Techniques and Applications
- Genetic factors in colorectal cancer
- Molecular Biology Techniques and Applications
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Medical Imaging and Pathology Studies
- Galectins and Cancer Biology
- Single-cell and spatial transcriptomics
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Gene expression and cancer classification
- Cell Image Analysis Techniques
- Head and Neck Cancer Studies
- Chronic Lymphocytic Leukemia Research
- Computational Drug Discovery Methods
Stanford University
2016-2025
Stanford Medicine
2016-2025
California Institute for Regenerative Medicine
2016-2025
Palo Alto University
2011-2025
Stratford University
2017-2025
Menlo School
2025
Cancer Institute (WIA)
2014-2024
Institute for Stem Cell Biology and Regenerative Medicine
2013-2024
VA Palo Alto Health Care System
2002-2024
Stanford Cancer Institute
2013-2023
Complete metastatic ablation of oligometastatic prostate cancer may provide an alternative to early initiation androgen deprivation therapy (ADT).To determine if stereotactic ablative radiotherapy (SABR) improves oncologic outcomes in men with cancer.The Observation vs Stereotactic Ablative Radiation for Oligometastatic Prostate Cancer (ORIOLE) phase 2 randomized study accrued participants from 3 US radiation treatment facilities affiliated a university hospital May 2016 March 2018 data...
Identifying molecular residual disease (MRD) after treatment of localized lung cancer could facilitate early intervention and personalization adjuvant therapies. Here, we apply personalized profiling by deep sequencing (CAPP-seq) circulating tumor DNA (ctDNA) analysis to 255 samples from 40 patients treated with curative intent for stage I-III 54 healthy adults. In 94% evaluable experiencing recurrence, ctDNA was detectable in the first posttreatment blood sample, indicating reliable...
The nature and extent of interindividual temporal variation in gene expression patterns specific cells tissues is an important relatively unexplored issue human biology. We surveyed peripheral blood from 75 healthy volunteers by using cDNA microarrays. Characterization the tissue essential foundation for recognition interpretation changes these associated with infections other diseases, was selected because it a uniquely accessible which to examine this patients or clinical setting. Specific...
Circulating tumour DNA (ctDNA) analysis facilitates studies of heterogeneity. Here we employ CAPP-Seq ctDNA to study resistance mechanisms in 43 non-small cell lung cancer (NSCLC) patients treated with the third-generation epidermal growth factor receptor (EGFR) inhibitor rociletinib. We observe multiple 46% after treatment first-line inhibitors, indicating frequent intra-patient Rociletinib recurrently involves MET, EGFR, PIK3CA, ERRB2, KRAS and RB1. describe a novel EGFR L798I mutation...
Glioblastoma multiforme (GBM) is the most common form of malignant glioma, characterized by genetic instability, intratumoral histopathological variability, and unpredictable clinical behavior. We investigated global gene expression in surgical samples brain tumors. Gene profiling revealed large differences between normal tumor tissues GBMs lower-grade oligodendroglial Extensive were found among GBMs, particularly genes involved angiogenesis, immune cell infiltration, extracellular matrix...
<h3>Importance</h3> The prevalence of early-stage non–small cell lung cancer (NSCLC) is expected to increase with recent implementation annual screening programs. Reliable prognostic biomarkers are needed identify patients at a high risk for recurrence guide adjuvant therapy. <h3>Objective</h3> To develop robust, individualized immune signature that can estimate prognosis in nonsquamous NSCLC. <h3>Design, Setting, and Participants</h3> This retrospective study analyzed the gene expression...
The explosion in the number of functional genomic datasets generated with tools such as DNA microarrays has created a critical need for resources that facilitate interpretation large-scale biological data. SOURCE is web-based database brings together information from broad range resources, and provides it manner particularly useful genome-scale analyses. SOURCE's GeneReports include aliases, chromosomal location, descriptions, GeneOntology annotations, gene expression data, links to external...
Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor in adults. We combined neuroimaging DNA microarray analysis to create a multidimensional map of gene-expression patterns GBM that provided clinically relevant insights into biology. Tumor contrast enhancement mass effect predicted activation specific hypoxia proliferation programs, respectively. Overexpression EGFR, receptor tyrosine kinase potential therapeutic target, was also directly inferred by validated an...
Patients with diffuse large B cell lymphoma (DLBCL) exhibit marked diversity in tumor behavior and outcomes, yet the identification of poor-risk groups remains challenging. In addition, biology underlying these differences is incompletely understood. We hypothesized that characterization mutational heterogeneity genomic evolution using circulating DNA (ctDNA) profiling could reveal molecular determinants adverse outcomes. To address this hypothesis, we applied cancer personalized by deep...
•Validated and sensitive ctDNA assays can be used to genotype advanced cancers select patients for targeted therapies.•Initial genotyping with should considered when rapid results are needed, tissue is unavailable.•ctDNA assay limited by false-negative results, lower sensitivity fusion events copy number changes.•Use of detect molecular residual disease not recommended, due lack evidence its clinical utility. Circulating tumour DNA (ctDNA) conducted on plasma rapidly developing a strong base...
The innate immune response is crucial for defense against microbial pathogens. To investigate the molecular choreography of this response, we carried out a systematic examination gene expression program in human peripheral blood mononuclear cells responding to bacteria and bacterial products. We found remarkably stereotyped induced by lipopolysaccharide diverse killed bacteria. An intricately choreographed devoted communication between was prominent feature response. Other features suggested...
Outcomes for patients with diffuse large B-cell lymphoma remain heterogeneous, existing methods failing to consistently predict treatment failure. We examined the additional prognostic value of circulating tumor DNA (ctDNA) before and during therapy predicting patient outcomes.We studied dynamics ctDNA from 217 treated at six centers, using a training validation framework. densely characterized early cancer personalized profiling by deep sequencing define response-associated thresholds...