A5050715497- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Systemic Lupus Erythematosus Research
- Cell Adhesion Molecules Research
- Psoriasis: Treatment and Pathogenesis
- Biosimilars and Bioanalytical Methods
- Attachment and Relationship Dynamics
- Angiogenesis and VEGF in Cancer
- Maternal Mental Health During Pregnancy and Postpartum
- Central Venous Catheters and Hemodialysis
- Cytokine Signaling Pathways and Interactions
- Vascular Procedures and Complications
- Autoimmune and Inflammatory Disorders Research
- Research on Leishmaniasis Studies
- Telomeres, Telomerase, and Senescence
- Orthopedic Infections and Treatments
- Vascular anomalies and interventions
- Dental Education, Practice, Research
- Platelet Disorders and Treatments
- Vitamin D Research Studies
- Bone and Joint Diseases
- Monoclonal and Polyclonal Antibodies Research
- Alcohol Consumption and Health Effects
- Child and Adolescent Psychosocial and Emotional Development
- Liver Disease Diagnosis and Treatment
Becton Dickinson (United States)
2025
Yale University
2024
Yale New Haven Hospital
2024
St. Vincent's University Hospital
2009-2021
Lady Reading Hospital
2018-2021
University of Birmingham
2012
University College Dublin
2011
Abstract Objective To assess blood vessel stability in inflammatory synovial tissue (ST) and to examine neural cell adhesion molecule (NCAM), oxidative DNA damage, hypoxia vivo. Methods Macroscopic vascularity ST oxygen levels were determined vivo patients with arthritis who undergoing arthroscopy. Vessel maturity/stability was quantified matched samples by dual immunofluorescence staining for factor VIII (FVIII)/α‐smooth muscle actin (α‐SMA). NCAM 8‐oxo‐7,8‐dihydro‐2′‐deoxyguanosine...
The aim of this study was to examine the effect blocking Toll-like receptor 2 (TLR2) in rheumatoid arthritis (RA) synovial cells.RA tissue biopsies, obtained under direct visualization at arthroscopy, were established as explant cultures ex vivo or snap frozen for immunohistology. Mononuclear cell isolated from peripheral blood and fluid RA patients. Cultures incubated with TLR1/2 ligand, Pam3CSK4 (200 ng, 1 10 μg/ml), an anti-TLR2 antibody (OPN301, μg/ml) immunoglobulin G (IgG) (1 matched...
Since remission is now possible in psoriatic arthritis (PsA) we wished to examine rates PsA patients following anti tumour necrosis factor alpha (TNFalpha) therapy and predictors of response.Analysis a prospective patient cohort attending biologic clinic, between November 2004 March 2008, was performed prior commencing at regular intervals. Baseline clinical characteristics including demographics, previous disease-modifying antirheumatic drug (DMARD) response, tender swollen joint counts,...
Background Angiogenesis is a critical early event in inflammatory arthritis, facilitating leukocyte migration into the synovium resulting invasion and destruction of articular cartilage bone. This study investigates effect TLR2 on angiogenesis, EC adhesion using microvascular endothelial cells RA whole tissue synovial explants ex-vivo. Methods Microvascular (HMVEC) ex vivo were cultured with ligand, Pam3CSK4 (1 µg/ml). Angiopoietin 2 (Ang2), Tie2 expression was assessed by immunohistology....
The effects of treatment in early rheumatoid arthritis (RA) and the consequences delayed therapy represent important areas for research. concept a 'window opportunity' is now well established considerable attention has been paid to when it might close. However, order study how long window opportunity lasts, timing its opening must be precisely defined. An analysis definitions 'onset' clinical studies reveals imprecision heterogeneity, making accurate assessment this very difficult. In paper...
Introduction This study examines the expression of IL-17A-secreting cells within inflamed synovium and relationship to in vivo joint hypoxia measurements. Methods IL-17A was quantified synovial tissue (ST), serum fluid (SF) by immunohistochemistry MSD-plex assays. IL-6 SF levels were measured Dual immunofluorescence for ST CD15+ (neutrophils), Tryptase+ (mast cells) CD4+ (T cells). Synovial oxygen (tpO2) under direct visualisation at arthroscopy. infiltration assessed using cell specific...
Abstract Background Biologic therapies have greatly improved outcomes in rheumatoid arthritis (RA) and psoriatic (PsA). Yet, our ability to predict long-term remission persistence or continuation of therapy remains limited. This study explores predictors the initial biologic patients after 12 years. Furthermore, with adalimumab etanercept are compared. Patients methods RA PsA were prospectively recruited from a clinic. Outcomes on commencing therapy, at 1 year years reviewed. Demographics,...
Abstract Purpose The AVeNEW Post-Approval Study (AVeNEW PAS) follows upon results from the IDE clinical trial and was designed to provide additional evidence of safety effectiveness using Covera™ Vascular Covered Stent treat arteriovenous fistula (AVF) stenoses in a real-world hemodialysis patient population. Materials Methods One hundred AVF patients were prospectively enrolled at 11 sites USA treated with covered stent after angioplasty clinically significant target stenosis. primary...
Objective The role of alcohol in inflammatory disease remains debated. This study explores the relationship between and activity patients with arthritis. Methods Patients attending a rheumatology clinic 2010 2020 were prospectively followed. Information on demographics, use, smoking habits outcome measures collected from these patients. Statistical analysis included univariate multivariate linear binary logistic regressions, Mann-Whitney U tests one-way variance Tukey’s honest significant...
Psoriatic arthritis (PsA) is a chronic inflammatory arthritis, usually seronegative for rheumatoid factor associated with psoriasis [Taylor et al. 2006; Reece 1999]. Although PsA was first described and classified in the 1970s it only more recent times that its serious consequences have been studied understood widely, not among rheumatologists but also broader medical community. The clinical phenotype varies which has led to difficulties classification, diagnosis therefore predicting...

 The present research was on the prevalence of marital conflicts among women having postpartum depression and from general population. sample 100 women, including 50 data collected after one week child birth. hypothesis “the will be higher in with than population”. tested by using chi-square test, highly significant results revealed that negatively effect relation. Similarly, difficulty understanding themselves they blamed comparing them without depression. Women when things went wrong...
<h3>Background</h3> Inflammatory arthritis (IA) is associated with an increased risk of cardiovascular events<sup>1,2</sup>, similarly known that high baseline serum amyloid A (SAA) levels and erosive disease are predictors aggressive arthritis<sup>3</sup>. <h3>Objectives</h3> To assess the influence markers early activity on long term outcome radiological progression in IA. <h3>Methods</h3> Patients were recruited prospectively followed for 4 years after commencing biological therapy...
Background: Biologic therapies have greatly improved outcomes in rheumatoid arthritis (RA) and psoriatic (PsA). Yet, our ability to predict long-term remission persistence or continuation of therapy remains limited. Objectives: To compare RA PsA at 1 12 years after commencing biologic DMARDs identify predictors therapy. Methods: patients were prospectively recruited from a clinic. Outcomes on therapy, year reviewed. Demographics, medications, morning stiffness, patient global health score,...