A5065688806- Immune Response and Inflammation
- Inflammasome and immune disorders
- NF-κB Signaling Pathways
- Immune cells in cancer
- interferon and immune responses
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- IL-33, ST2, and ILC Pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune responses and vaccinations
- Asthma and respiratory diseases
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Immunotherapy and Immune Responses
- Influenza Virus Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Phagocytosis and Immune Regulation
- Genomics, phytochemicals, and oxidative stress
- Pediatric health and respiratory diseases
- Circular RNAs in diseases
- Chemokine receptors and signaling
- Epigenetics and DNA Methylation
Trinity College Dublin
2016-2025
Molecular Medicine Ireland
2007-2023
UK Health Security Agency
2023
Hôpital Jean-Verdier
2023
Indian Institute of Science Bangalore
2020
University of Sheffield
2000-2019
GlaxoSmithKline (United Kingdom)
2018-2019
East Tennessee State University
2018-2019
22q11 Ireland
2019
MRC Mitochondrial Biology Unit
2018
Epigenetic reprogramming of myeloid cells, also known as trained immunity, confers nonspecific protection from secondary infections. Using histone modification profiles human monocytes with the Candida albicans cell wall constituent β-glucan, together a genome-wide transcriptome, we identified induced expression genes involved in glucose metabolism. Trained display high consumption, lactate production, and ratio nicotinamide adenine dinucleotide (NAD(+)) to its reduced form (NADH),...
A New Linc in Innate Immunity Long noncoding RNAs (lncRNAs) have recently emerged as important regulators of gene expression a wide variety biological processes, although specific roles for these molecules the immune system not been described. Carpenter et al. (p. 789 , published online 1 August) now define function one such lncRNA system, lincRNA-Cox2. Whole-transcriptome profiling revealed that lincRNA-Cox2 was induced mouse macrophages response to activation Toll-like receptors—molecules...