Evangelos J. Giamarellos‐Bourboulis
A5011316933- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Immune Response and Inflammation
- Antibiotics Pharmacokinetics and Efficacy
- Hidradenitis Suppurativa and Treatments
- Antibiotic Resistance in Bacteria
- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
- Colorectal and Anal Carcinomas
- Inflammation biomarkers and pathways
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 and COVID-19 Research
- Antimicrobial Resistance in Staphylococcus
- Intensive Care Unit Cognitive Disorders
- Immune responses and vaccinations
- Microscopic Colitis
- Neonatal and Maternal Infections
- Inflammasome and immune disorders
- Orthopedic Infections and Treatments
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Antibiotic Use and Resistance
- Streptococcal Infections and Treatments
National and Kapodistrian University of Athens
2016-2025
University General Hospital Attikon
2015-2024
Athens Medical Center
2000-2024
Translational Therapeutics (United States)
2024
University of Pennsylvania
2024
Michigan Medicine
2024
University of Thessaly
2020-2022
Heinrich Heine University Düsseldorf
2020-2022
Düsseldorf University Hospital
2020-2022
University of Michigan–Ann Arbor
2020-2022
Epigenetic reprogramming of myeloid cells, also known as trained immunity, confers nonspecific protection from secondary infections. Using histone modification profiles human monocytes with the Candida albicans cell wall constituent β-glucan, together a genome-wide transcriptome, we identified induced expression genes involved in glucose metabolism. Trained display high consumption, lactate production, and ratio nicotinamide adenine dinucleotide (NAD(+)) to its reduced form (NADH),...
Monocyte differentiation into macrophages represents a cornerstone process for host defense. Concomitantly, immunological imprinting of either tolerance or trained immunity determines the functional fate and susceptibility to secondary infections. We characterized transcriptomes epigenomes in four primary cell types: monocytes vitro-differentiated naïve, tolerized, macrophages. Inflammatory metabolic pathways were modulated macrophages, including decreased inflammasome activation, we...
Hidradenitis suppurativa is a painful, chronic inflammatory skin disease with few options for effective treatment. In phase 2 trial, adalimumab, an antibody against tumor necrosis factor α, showed efficacy hidradenitis suppurativa.PIONEER I and II were similarly designed, 3 multicenter trials of adalimumab suppurativa, two double-blind, placebo-controlled periods. period 1, patients randomly assigned in 1:1 ratio to 40 mg weekly or matching placebo 12 weeks. 2, reassigned at every-other-week...
Abstract Early increase of soluble urokinase plasminogen activator receptor (suPAR) serum levels is indicative increased risk progression coronavirus disease 2019 (COVID-19) to respiratory failure. The SAVE-MORE double-blind, randomized controlled trial evaluated the efficacy and safety anakinra, an IL-1α/β inhibitor, in 594 patients with COVID-19 at progressing failure as identified by plasma suPAR ≥6 ng ml −1 , 85.9% ( n = 510) whom were receiving dexamethasone. At day 28, adjusted...
Treatment options for carbapenem-resistant Enterobacteriaceae (CRE) infections are limited and CRE remain associated with high clinical failure mortality rates, particularly in vulnerable patient populations. A Phase 3, multinational, open-label, randomized controlled trial (TANGO II) was conducted from 2014 to 2017 evaluate the efficacy/safety of meropenem-vaborbactam monotherapy versus best available therapy (BAT) CRE.A total 77 patients confirmed/suspected infection (bacteremia,...
A validated tool for the dynamic severity assessment of hidradenitis suppurativa/acne inversa (HS) is lacking. To develop and validate a novel scoring system to assess HS. Delphi voting procedure was conducted among members European Hidradenitis Suppurativa Foundation (EHSF) achieve consensus towards an initial HS Severity Score System (HS4). Strengths weaknesses HS4 were examined by multicentre prospective study. Multivariate logistic regression, discriminant analysis receiver operating...
Infectious diseases exert a constant evolutionary pressure on the genetic makeup of our innate immune system. Polymorphisms in Toll-like receptor 4 (TLR4) have been related to susceptibility Gram-negative infections and septic shock. Here we show that two polymorphisms TLR4, Asp299Gly Thr399Ile, unique distributions populations from Africa, Asia, Europe. Genetic functional studies are compatible with model which nonsynonymous polymorphism has evolved as protective allele against malaria,...
Abstract Objective The concept that intraarticular crystals of uric acid by themselves trigger episodes painful gouty arthritis is inconsistent with the clinical reality. Patients large deposits monosodium urate monohydrate (MSU) (tophi) do not necessarily experience attacks. In fact, it excessive consumption food or alcohol elicits inflammation acute gout attack. aim this study was to identify precise mechanism initiates flares arthritis. Methods Human peripheral blood mononuclear cells...
<h3>Importance</h3> Meropenem-vaborbactam is a combination carbapenem/beta-lactamase inhibitor and potential treatment for severe drug-resistant gram-negative infections. <h3>Objective</h3> To evaluate efficacy adverse events of meropenem-vaborbactam in complicated urinary tract infection (UTI), including acute pyelonephritis. <h3>Design, Setting, Participants</h3> Phase 3, multicenter, multinational, randomized clinical trial (TANGO I) conducted November 2014 to April 2016 enrolling...
Hidradenitis suppurativa (HS) is a common skin disorder in which excessive inflammation believed to have an important role. There no specific therapy for HS.To investigate the safety and efficacy of anti-inflammatory biological anakinra HS.Double-blind, randomized, placebo-controlled clinical trial with 12-week treatment phase follow-up phase. The setting was Attikon University General Hospital, tertiary care institution Athens, Greece. Participants were 20 patients Hurley stage II or III...
Abstract Background. Intravenous colistin is difficult to use because plasma concentrations for antibacterial effect overlap those causing nephrotoxicity, and there large interpatient variability in pharmacokinetics. The aim was develop dosing algorithms achievement of a clinically desirable average steady-state concentration (Css,avg) 2 mg/L. Methods. Plasma concentration-time data from 214 adult critically ill patients (creatinine clearance, 0–236 mL/min; 29 receiving renal replacement...