A5032610869- Dermatologic Treatments and Research
- Facial Rejuvenation and Surgery Techniques
- Enzyme-mediated dye degradation
- Skin Protection and Aging
- Acne and Rosacea Treatments and Effects
- Body Contouring and Surgery
- Reconstructive Facial Surgery Techniques
- Hair Growth and Disorders
- Photodynamic Therapy Research Studies
- Biochemical and biochemical processes
- Autoimmune Bullous Skin Diseases
- Body Image and Dysmorphia Studies
- Botulinum Toxin and Related Neurological Disorders
- Microbial Metabolism and Applications
- Chromium effects and bioremediation
- Medicine and Dermatology Studies History
- Laser Applications in Dentistry and Medicine
- Nail Diseases and Treatments
- Surgical Sutures and Adhesives
- melanin and skin pigmentation
- Dermatology and Skin Diseases
- Nonmelanoma Skin Cancer Studies
- Lignin and Wood Chemistry
- Electrochemical sensors and biosensors
- Fungal Biology and Applications
Gold Skin Care Center
2016-2025
Tennessee Clinical Research Center
2016-2025
Vanderbilt University
2013-2024
Fondazione Lombardia per l’Ambiente
2022
Hunan Normal University
2021
Nashville Oncology Associates
2000-2021
Dr. D. Y. Patil Medical College, Hospital and Research Centre
2021
Worldwide Laser Institute
2021
Ahmedabad University
2021
Brown University
2021
Manganese oxidation by manganese peroxidase (MnP) was investigated. Stoichiometric, kinetic, and MnII binding studies demonstrated that MnP has a single site near the heme, two MnIII equivalents are formed at expense of one H2O2 equivalent. Since each catalytic cycle step is irreversible, data fit ping-pong mechanism rather than an ordered bi-bi mechanism. MnIII-organic acid complexes oxidize terminal phenolic substrates in second-order reaction. MnIII-lactate -tartrate also react slowly...
A human antibody to interleukin-17A is well tolerated and may be effective in the treatment of psoriasis, rheumatoid arthritis, noninfectious uveitis.
Two H 2 O ‐dependent oxidases found in the extracellular medium of white rot fungus Phanerochaete chrysosporium were separated by chromatography on blue agarose. The first enzyme fraction to elute from column generated ethylene 2‐keto‐4‐thiomethylbutyric acid (KTBA) presence veratryl alcohol, and catalyzed α,β cleavage diarylpropane 1‐(3,4‐diethoxyphenyl)1,3‐dihdyroxy‐(4‐methoxyphenyl)propane (I). During cleavage, 18 was incorporated specifically into α‐position product...
Hidradenitis suppurativa is a painful, chronic inflammatory skin disease with few options for effective treatment. In phase 2 trial, adalimumab, an antibody against tumor necrosis factor α, showed efficacy hidradenitis suppurativa.PIONEER I and II were similarly designed, 3 multicenter trials of adalimumab suppurativa, two double-blind, placebo-controlled periods. period 1, patients randomly assigned in 1:1 ratio to 40 mg weekly or matching placebo 12 weeks. 2, reassigned at every-other-week...
The polymeric dyes Poly B-411, R-481, and Y-606 were examined as possible alternatives to the radiolabeled lignin previously used a substrate in biodegradation assays. Like degradation, decolorization of these by white rot basidiomycete Phanerochaete chrysosporium occurred during secondary metabolism, was suppressed cultures grown presence high levels nitrogen, strongly dependent on oxygen concentration cultures. A variety inhibitors including thiourea, azide, 4′- O -methylisoeugenol, also...
The crystal structure of manganese peroxidase (MnP) from the lignin-degrading basidiomycetous fungus Phanerochaete chrysosporium has been solved using molecular replacement techniques and refined to R = 0.20 at 2.0 A. overall is similar that two other fungal peroxidases, lignin P. Arthromyces ramosus peroxidase. Like MnP structural calcium ions. also N-acetylglucosamine residues N-linked Asn131 are readily visible in electron density map. active site, consisting a proximal His ligand...
In 2002, an international advisory panel was convened to assess the scientific literature and develop evidence-based guidance for prevention treatment of pathologic scarring. Emerging clinical data, new options, technical advances warranted a renewed search review initial recommendations.To update management algorithm scarring reflect best practice standards at present.Management recommendations were derived from evidence amassed during comprehensive experience consensus opinion members.A...
Introduction Skin aging occurs through both intrinsic and extrinsic processes. Fractional radiofrequency (RF) with a microneedling array is the newest form of fractional therapy to be useful in treating skin. The current study utilized noninsulated RF system. Methods This multicenter clinical trial saw 49 patients complete 3 monthly treatments new followed for months following their last treatment. Pain during treatment was recorded as well overall improvement using GAIS scale. Adverse...
Abstract A preliminary observation of high frequency male pattern hair loss among admitted COVID‐19 patients and suggest that androgen expression might be a clue to severity.
Abstract Background Microplastics (MPs) and nanoplastics (NPs) have become a growing concern in dermatology due to their widespread presence cosmetic formulations the environment. These minuscule synthetic polymer particles prompt an essential exploration of potential impact on dermatological homeostasis. Aims This study aims investigate effects MPs NPs integumentary system. Specifically, it seeks understand cutaneous alterations, inflammatory responses, disruptions skin's physiological...
Under nitrogen-limiting, secondary metabolic conditions, the white rot basidiomycete Phanerochaete chrysosporium extensively mineralized specifically 14C-ring-labeled azo dyes 4-phenylazophenol, 4-phenylazo-2-methoxyphenol, Disperse Yellow 3 [2-(4'-acetamidophenylazo)-4-methylphenol], 4-phenylazoaniline, N,N-dimethyl-4-phenylazoaniline, Orange [4-(4'-nitrophenylazo)-aniline], and Solvent 14 (1-phenylazo-2-naphthol). Twelve days after addition to cultures, had been 23.1 48.1%. Aromatic rings...
The crystal structure of the major lignin peroxidase isozyme from Phanerocheate chrysosporium has been Tefined to an R = 0.15 for data between 8 A and 2.03A. refined model consists 2 molecules in asymmetric unit, calcium ions per monomer, 1 glucosamine monomer N-linked Asn-257, 476 water unit.The exhibits excellent geometry with a root mean square deviation fFom ideality bond distances angles 0.014 2.9", respectively.Molecule all 343 residues, while molecule residues 1-341.The overall...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTManganese peroxidase from the basidiomycete Phanerochaete chrysosporium: spectral characterization of oxidized states and catalytic cycleHiroyuki Wariishi, Lakshmi Akileswaran, Michael H. GoldCite this: Biochemistry 1988, 27, 14, 5365–5370Publication Date (Print):July 12, 1988Publication History Published online1 May 2002Published inissue 12 July 1988https://pubs.acs.org/doi/10.1021/bi00414a061https://doi.org/10.1021/bi00414a061research-articleACS...
Extracellular manganese peroxidase and laccase activities were detected in cultures of Dichomitus squalens (Polyporus anceps) under conditions favoring lignin degradation. In contrast, neither extracellular nor aryl alcohol oxidase activity was grown a wide variety conditions. The mineralization 14C-ring-, -side chain-, -methoxy-labeled synthetic guaiacyl lignins by D. the expression dependent on presence Mn(II), suggesting that is an important component this organism's degradation system....
Under secondary metabolic conditions the white rot basidiomycete Phanerochaete chrysosporium mineralizes 2,4-dichlorophenol (I). The pathway for degradation of (I) was elucidated by characterization fungal metabolites and oxidation products generated purified lignin peroxidase manganese peroxidase. multistep involves oxidative dechlorination to yield 1,2,4,5-tetrahydroxybenzene (VIII). intermediate (VIII) is ring cleaved produce, after subsequent oxidation, malonic acid. In first step...
Under secondary metabolic conditions, the white-rot basidiomycete Phanerochaete chrysosporium degraded 2,7-dichlorodibenzo-p-dioxin (I). The pathway for degradation of I was elucidated by characterization fungal metabolites and oxidation products generated lignin peroxidase (LiP), manganese (MnP), crude intracellular cell-free extracts. multistep involves subsequent intermediates oxidation, reduction, methylation reactions to yield key intermediate 1,2,4-trihydroxybenzene (III). In first...