A5002831147- Hair Growth and Disorders
- Dermatologic Treatments and Research
- Nail Diseases and Treatments
- melanin and skin pigmentation
- Dermatology and Skin Diseases
- Skin and Cellular Biology Research
- COVID-19 Clinical Research Studies
- Vector-borne infectious diseases
- SARS-CoV-2 and COVID-19 Research
- Dermatological and COVID-19 studies
- Sexual Differentiation and Disorders
- COVID-19 Impact on Reproduction
- Food Allergy and Anaphylaxis Research
- Tuberculosis Research and Epidemiology
- PARP inhibition in cancer therapy
- Dyeing and Modifying Textile Fibers
- Diagnosis and treatment of tuberculosis
- Skin Protection and Aging
- Viral Infections and Vectors
- Mycobacterium research and diagnosis
- Contact Dermatitis and Allergies
- Nosocomial Infections in ICU
- Advancements in Transdermal Drug Delivery
- Alkaline Phosphatase Research Studies
- Heterotopic Ossification and Related Conditions
John Snow (United States)
2024
University Hospital Centre Zagreb
2018-2023
Sisters of Charity Hospital
2018-2020
Marconi University
2015-2019
European University of Rome
2017
Croatian Science Foundation
2016
Abstract A preliminary observation of high frequency male pattern hair loss among admitted COVID‐19 patients and suggest that androgen expression might be a clue to severity.
Antiandrogens have demonstrated a protective effect for COVOD-19 patients in observational and interventional studies. The goal of this study was to determine if proxalutamide, an androgen receptor antagonist, could be effective treatment men with COVID-19 outpatient setting. A randomized, double-blinded, placebo-controlled clinical trial conducted at two centers (Brasilia, Brazil). Patients were recruited from October 21 December 24, 2020 (clinicaltrials.gov number, NCT04446429). Male...
Vitiligo is depigmenting disorder of the skin and mucous membranes but despite various therapeutic options, complete satisfactory treatment vitiligo still remains a challenge. Therapeutic success also varies depending on localization lesions; hands bony prominents are considered to be resistant treatment. We investigated feasibility treating bilateral symmetrical vulgaris acrofacialis lesions with combination narrowband UVB topical prostaglandins (0.005% latanoprost solution) or without...
Male androgenetic alopecia (AGA) affects up to 60% of men by the age 50. Currently, there are only two approved drugs for treatment male AGA: topical minoxidil and oral finasteride. Topical is readily available over counter has a well-established safety record. However, following 24 weeks treatment, less than 40% respond drug. Additionally, due route administration, compliance with remains low. In contrast, finasteride, 5-alpha reductase inhibitor, demonstrated efficacy in arresting hair...
Minoxidil sulfate is the active metabolite required to exert vasodilatory and hair growing effects of minoxidil. For growth, sulfotransferase enzymes expressed in outer root sheath follicle sulfonate The large intra-subject variability follicular was found predict minoxidil response thus explain low rate topical treatment androgenetic alopecia. A method increase would be significant clinical utility. Retinoids have been reported response. purported mechanism action retinoid modulation skin...
Topical minoxidil is the only US FDA approved OTC drug for treatment of androgenetic alopecia (AGA). Minoxidil a pro-drug converted into its active form, sulfate, by sulfotransferase enzymes in outer root sheath hair follicles. Previously, we demonstrated that activity follicles predicts response to topical AGA. In human liver, significantly inhibited salicylic acid. Low-dose aspirin (75–81 mg), derivative acid, used millions people daily prevention coronary heart disease and cancer. It not...
Atopic dermatitis (AD) is a common and chronic inflammatory skin disease that erupts periodically. Although the negative impact of disorder on overall quality life has been well established, new treatments for AD are still needed. Various studies have reported cannabidiol's effectiveness in relieving pain easing inflammation while not presenting major health risks. In this communication, we aim to demonstrate novel cannabidiol (CBD) aspartame formulation, JW-100, signs symptoms AD. We...
The clinical application of transdermal delivery has been limited to lipophilic drugs with a molecular weight less than 500 Da. development polymeric microneedles enabled the larger proteins and drugs. Extensive research conducted on size, solubility, pH, concentration, polarity delivery; however, maximal for microneedle not established. Clinicians often use simple deliver high growth factors platelet-rich plasma across skin; thus, we set out explore feasibility delivering through...
<h3>Introduction:</h3> Since the health information system (HIS) in public care services Serbia was introduced 2009, it has gradually expanded. However, is unclear how well HIS components have developed and whole system's stage of maturity. <h3>Method:</h3> In June–September 2021, a maturity assessment Serbian conducted for first time using Stages Continuous Improvement (SOCI) toolkit. The toolkit measures status across 5 domains: leadership governance, management workforce, communication...
Abstract Background Minoxidil is a widely used over‐the‐counter topical treatment for hair loss. The response rate minoxidil relatively low. pro‐drug, converted to its active form, sulfate, by SULT1A1 enzymes located in the scalp. Recently, novel formula that increases activity of follicles was reported. Aims To evaluate any benefit applying enzyme booster prior daily 5% treatment. Methods Male androgenic alopecia patients were recruited randomized blinded placebo‐controlled study. Patients...
Several studies have established that sulfotransferase enzyme activity in the outer root sheath of plucked hair follicles predicts response to topical minoxidil treatment pattern loss. However, prevalence this among Indian patients has not been studied. Additionally, no reports literature characterize based on sex, age, duration loss, grade and family history. In study we utilized a assay first reported by Goren et al. We follicular 120 loss visiting dermatology outpatient clinic India....
Hair shedding in female patients is a frequent complaint dermatological, endocrinological, and gynecological consults. Previously, the Sinclair Shedding Scale was developed to assess normal versus excessive hair pattern loss (FPHL) subjects. However, prevalence of females not suffering from FPHL unknown. To gain better understanding general population, we recruited 300 subjects visiting public hospital for conditions other than alopecia. Of recruited, 263 did suffer FPHL. Among those...
ResultsSubjects completed the study with an average of 3.63 sessions.The increase in hair counts from baseline treatment group was higher than placebo 22.8% vs 9.6% (p = 0.08).
Traction alopecia is hair loss that occurs after persistent pulling (e.g., during cosmetic procedures) on the roots of over time. Unlike plucking, which painful, may go unnoticed until a patient presents with either bald spots or diffuse telogen shedding. Each follicle in scalp contains an arrector pili muscle that, when contracted, erects hair. The smooth expresses α1 adrenergic receptors (α1-AR). As such, we hypothesized contraction via α1-AR agonist would increase threshold force required...
Female alopecia patients in China often present with a frontal pattern hair loss. This feature is seen less frequently western women. Women style their ponytail. Thus, we hypothesized that the high prevalence of loss Chinese women due to traction alopecia. To better understand this, studied 43 presenting at clinic. Among alopecia, 79% reported styling ponytail four or more days per week for an average period 10 years. our knowledge, this first study elucidate cause frequent Although cultural...
Approximately 40% of women experience excessive hair shedding when washing their hair. Previously, we have demonstrated that a topically applied α1 adrenergic receptor agonist can be used to contract the arrector pili muscle follicular unit (ie, produce "goose bumps"), increasing force required pluck by as much 400%. Subsequently, reported topical cosmetic solution containing an reduced during brushing maximum 77%.In this communication, explore novel mechanism muscle. Trace amine-associated...