Efthymia Giannitsioti
A5052626943- Infective Endocarditis Diagnosis and Management
- Antimicrobial Resistance in Staphylococcus
- Orthopedic Infections and Treatments
- Infectious Diseases and Tuberculosis
- Streptococcal Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- COVID-19 Clinical Research Studies
- Antibiotic Use and Resistance
- Sepsis Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Osteomyelitis and Bone Disorders Research
- Long-Term Effects of COVID-19
- Infectious Aortic and Vascular Conditions
- Bacterial biofilms and quorum sensing
- Nosocomial Infections in ICU
- Antibiotic Resistance in Bacteria
- SARS-CoV-2 and COVID-19 Research
- Patient Satisfaction in Healthcare
- Antifungal resistance and susceptibility
- Inflammasome and immune disorders
- Orthopaedic implants and arthroplasty
- Cardiac, Anesthesia and Surgical Outcomes
- Brucella: diagnosis, epidemiology, treatment
- Pneumocystis jirovecii pneumonia detection and treatment
National and Kapodistrian University of Athens
2012-2025
Laiko General Hospital of Athens
2024-2025
University General Hospital Attikon
2012-2023
Tzaneion General Hospital
2021-2023
National Bank of Greece (Greece)
2021
Duke University Hospital
2017
Duke Medical Center
2017
Barwon Health
2014
Masaryk University
2014
Deakin University
2014
Abstract Early increase of soluble urokinase plasminogen activator receptor (suPAR) serum levels is indicative increased risk progression coronavirus disease 2019 (COVID-19) to respiratory failure. The SAVE-MORE double-blind, randomized controlled trial evaluated the efficacy and safety anakinra, an IL-1α/β inhibitor, in 594 patients with COVID-19 at progressing failure as identified by plasma suPAR ≥6 ng ml −1 , 85.9% ( n = 510) whom were receiving dexamethasone. At day 28, adjusted...
Use of surgery for the treatment infective endocarditis (IE) as related to surgical indications and operative risk mortality has not been well defined.The International Collaboration on Endocarditis-PLUS (ICE-PLUS) is a prospective cohort consecutively enrolled patients with definite IE from 29 centers in 16 countries. We included ICE-PLUS left-sided, non-cardiac device-related who were between September 1, 2008, December 31, 2012. A total 1296 left-sided included. Surgical was performed 57%...
This clinical guideline is intended for use by orthopedic surgeons and physicians who care patients with possible or documented septic arthritis of a native joint (SANJO). It includes evidence opinion-based recommendations the diagnosis management SANJO.
Although major changes of the immune system have been described in sepsis, it has never studied whether these may differ relation to type underlying infection or not. This was for first time.The statuses innate and adaptive systems were prospectively compared 505 patients. Whole blood sampled within less than 24 hours advent sepsis; white cells stained with monoclonal antibodies analyzed though a flow cytometer.Expression HLA-DR significantly decreased among patients severe sepsis/shock due...
Streptococci are not an infrequent cause of periprosthetic joint infection (PJI). Management by debridement, antibiotics, and implant retention (DAIR) is thought to produce a good prognosis, but little known about the real likelihood success. A retrospective, observational, multicenter, international study was performed during 2003–2012. Eligible patients had streptococcal PJI that managed with DAIR. The primary endpoint failure, defined as death related infection, relapse/persistence or...
Background. The impact of early valve surgery (EVS) on the outcome Staphylococcus aureus (SA) prosthetic infective endocarditis (PVIE) is unresolved. objective this study was to evaluate association between EVS, performed within first 60 days hospitalization, and SA PVIE International Collaboration Endocarditis–Prospective Cohort Study.
Spondylodiscitis may involve the vertebral bodies, intervertebral discs, paravertebral structures and spinal canal, with potentially high morbidity mortality rates.A rise in susceptible population improved diagnosis have increased reported incidence of disease recent years.Blood cultures, appropriate imaging biopsy are essential for treatment.Most patients successfully treated by conservative means; however, some require surgical treatment.Surgical indications include doubtful diagnosis,...
Abstract Background Sepsis guidelines suggest immediate start of resuscitation for patients with quick Sequential Organ Failure Assessment (qSOFA) 2 or 3. However, the interpretation qSOFA 1 remains controversial. We investigated whether measurements soluble urokinase plasminogen activator receptor (suPAR) may improve risk detection when is 1. Methods The study had two parts. At first part, combination suPAR was analyzed in a prospective cohort early detection. second double-blind,...
The in vitro activities of tigecycline and selected antimicrobials were evaluated against a variety multiple-drug-resistant clinical isolates, including extended-spectrum beta-lactamase- and/or metallo-beta-lactamase-producing gram-negative strains, colistin-resistant vancomycin- linezolid-resistant enterococci, methicillin-resistant Staphylococcus aureus (MRSA). Tigecycline showed excellent activity collection difficult-to-treat pathogens currently encountered the hospital setting.
Antibiotic resistance has been associated with the use of antibiotics. The dispensing antimicrobials without prescription is a potential source inappropriate antibiotic use. In our study, antibiotics were requested from pharmacies in metropolitan area Athens Greece 2008. Twenty-one collaborators visited 174 and asked for either amoxicillin/clavulanate acid or ciprofloxacin providing any other justification request. additional restrictions fluoroquinolone prescriptions implemented 2003 after...
Candida infective endocarditis is a rare disease with high mortality rate. Our understanding of this infection derived from case series, reports, and small prospective cohorts. The purpose study was to evaluate the clinical features use different antifungal treatment regimens for endocarditis. This cohort based on 70 cases International Collaboration Endocarditis (ICE)-Prospective Cohort Study ICE-Plus databases collected between 2000 2010. majority infections were acquired nosocomially...
Most patients infected with SARS-CoV-2 (COVID-19) experience mild, non-specific symptoms, but many develop severe symptoms associated an excessive inflammatory response. Elevated plasma concentrations of soluble urokinase plasminogen activator receptor (suPAR) provide early warning progression to respiratory failure (SRF) or death, access suPAR testing may be limited. The Severe COvid Prediction Estimate (SCOPE) score, derived from circulating C-reactive protein, D- dimers, interleukin-6,...
In left-sided infective endocarditis (IE), a large vegetation >10 mm is associated with higher mortality, yet it unknown whether surgery during the acute phase opposed to medical therapy improved survival. We assessed association between and 6-month mortality as related size.Patients definite, IE (2008-2012) from The International Collaboration on Endocarditis prospective, multinational registry were included. compared clinical characteristics (by Cox regression inverse propensity of...
Background: Bloodstream infections (BSI) caused by highly resistant pathogens in non-ICU COVID-19 departments pose important challenges. Methods: We performed a comparative analysis of incidence and microbial epidemiology BSI vs. non-COVID-19, between 1 September 2020-31 October 2021. Risk factors for its impact on outcome were evaluated case-control study which included patients with/without BSI. Results: Forty out 1985 developed The mean monthly incidence/100 admissions was 2.015 1.742...
Background The pandemic by the novel H1N1 virus has created need to study any probable effects of that infection in immune system host. Methodology/Principal Findings Blood was sampled within first two days presentation signs from 10 healthy volunteers; 18 cases flu-like syndrome; and 31 confirmed reverse RT-PCR. Absolute counts subtypes monocytes lymphocytes were determined after staining with monoclonal antibodies analysis flow cytometry. Peripheral blood mononuclear cells (PBMCs) isolated...
The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine patient following prolonged exposure to echinocandins (38 days followed by 16 anidulafungin) is described. isolate harbored the novel alteration F652S in hotspot 1 region fks1. Isogenic C. bloodstream isolates collected up 1.5 months earlier same were susceptible caspofungin 1−2, mg/L, respectively) contained wild-type FKS1...