A5034046142- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Surgical site infection prevention
- Infective Endocarditis Diagnosis and Management
- Sports injuries and prevention
- Knee injuries and reconstruction techniques
- Infectious Diseases and Tuberculosis
- Periodontal Regeneration and Treatments
- Antimicrobial Resistance in Staphylococcus
- Shoulder Injury and Treatment
- Oral and gingival health research
- Hip disorders and treatments
- Bacteriophages and microbial interactions
- Bacillus and Francisella bacterial research
- Clinical practice guidelines implementation
- Bone Tissue Engineering Materials
- Dental Health and Care Utilization
- Monoclonal and Polyclonal Antibodies Research
- Dental Education, Practice, Research
- Pelvic and Acetabular Injuries
- Wound Healing and Treatments
- Bone and Joint Diseases
- Osteoarthritis Treatment and Mechanisms
- Hip and Femur Fractures
OLVG
2014-2025
Joint Research Centre
2020-2021
University of Toronto
2013-2021
Maastricht University Medical Centre
2016-2018
GGD Amsterdam
2018
St. Michael's Hospital
2013
University Medical Center Utrecht
2002-2010
Utrecht University
2007-2010
Heidelberg University
2008
University Hospital Heidelberg
2008
Abstract Platelet‐leukocyte gel (PLG) contains high concentrations of platelets and leukocytes. As leukocytes play an important role in the innate host‐defense, we hypothesized that PLG might have antimicrobial properties. This study investigated activity against Staphylococcus aureus contribution myeloperoxidase (MPO), present leukocytes, this process. Platelet‐rich plasma (PRP) platelet‐poor (PPP) were obtained from whole blood six donors. was prepared by mixing PRP with autologous...
Despite modern fracture management techniques allowing for near anatomic reduction of acetabular fractures, there continues to be a risk posttraumatic arthritis and need total hip arthroplasty (THA). Few well-controlled studies have compared THA after fractures with THAs performed other indications in terms survivorship or complications, none, our knowledge, present 10-year data this setting.(1) How does the survival compare between those patients who underwent an primary avascular necrosis...
This clinical guideline is intended for use by orthopedic surgeons and physicians who care patients with possible or documented septic arthritis of a native joint (SANJO). It includes evidence opinion-based recommendations the diagnosis management SANJO.
Purpose We investigated the hypothesis that many total hip arthroplasty revisions are classified as aseptic in fact low-grade infections missed with routine diagnostics. Methods In 7 Dutch hospitals, 176 consecutive patients preoperative diagnosis of loosening their were enrolled. During surgery, between 14 and 20 tissue samples obtained for culture, pathology, broad-range 16S rRNA PCR reverse line blot hybridization. Patients either not being infected, suspected having infection, or...
Several studies suggest that histologic findings from tissues obtained at revision arthroplasty for failed metal-on-metal (MOM) total hip implants may reflect an immune reaction to particles or ions in some patients. However, only a limited number of cases without MOM were reported as controls those studies.The purpose this study is better define the extent and distribution morphologic features attributed sampled surgery nonMOM THA.As part multicenter, prospective study, we reviewed 612...
Culture remains the gold standard in diagnosis of bacterial infection, but molecular biological techniques have yielded promising results. In this study, we validated a combined polymerase chain reaction and reverse line blot hybridization protocol for identifying musculoskeletal infections.Samples were obtained from seventy-six patients undergoing orthopaedic surgery various aseptic septic indications. The infection was based on review all available clinical culture data. addition to...
Background and purpose: This study introduces an innovative research design in the field of orthopedics, using a target trial emulation approach. We aimed to assess causal effects total hip arthroplasty (THA) compared with nonoperative treatment reducing patient-reported disability at 3 months patients osteoarthritis, real-world data.Methods: emulated data 2 Dutch hospitals between April 2020 January 2022. Patients diagnosed osteoarthritis eligible for primary THA were included study. During...
No options are available for local antibiotic delivery from uncemented implants. By loading a porous titanium implant with biomimetic HA-coating (PeriApatite, PA) antibiotics, we could obtain adequate concentrations and reduce infection susceptibility. This study investigated the efficacy of tobramycin-loaded PA-coated foam in preventing infection, as well effects on osseointegration. In 72 New Zealand White rabbits, an uncoated (Ti), (PA), or Tobramycin-PA-coated (PA-tobra) rod was...
In recent years, the field of cartilage tissue engineering has seen a sharp increase in publications using many techniques and various analysis methods. Comparison between studies remains difficult, due to lack uniformity methods used. A broad range histological scoring systems is used examine quality. Unfortunately, so far little known on reliability correlation these systems. The objective this study was compare two frequently repair grading scales, namely, comprehensive O'Driscoll simple...
Aseptic loosening and infection are 2 of the most common causes revision hip implants. Antibiotic prophylaxis reduces not only rate due to but also aseptic loosening. This suggests under-diagnosis infections in patients with presumed indicates that current diagnostic tools suboptimal. In a previous multicenter study on 176 undergoing total arthroplasty loosening, optimized diagnostics revealed 4-13% had low-grade infection. These were treated as such, follow-up effect mid- long-term implant...
Abstract Data from literature showed that a new type of metallic silver PMMA cement had good results in infection prophylaxis. This study investigated the vivo efficacy prevention methicillin‐sensitive Staphylococcal infections, compared to plain and tobramycin‐containing cement. In 48 rabbits, 0.6% silver, 1% plain, or tobramycin was injected into femoral medullary canal after contamination with 10 5 , 6 7 colony forming units (CFU) Staphylococcus aureus . After 14 days, bone collected for...
Background: Responsiveness and the minimal important change (MIC) are measurement properties to evaluate treatment effects interpret clinical trial results. The International Knee Documentation Committee (IKDC) Subjective Form is a reliable valid instrument for measuring patient-reported knee-specific symptoms, functioning, sports activities in population with meniscal tears. However, evidence on responsiveness of limited methodological quality, MIC has not yet been established patients...
Background and purpose — The optimal type duration of antibiotic prophylaxis for primary arthroplasty the hip knee are subject to debate. We compared risk complete revision (obtained by a 1- or 2-stage procedure) periprosthetic joint infection (PJI) after total between patients receiving single dose prophylactic antibiotics multiple doses prevention PJI. Patients methods A cohort 130,712 111,467 arthroplasties performed 2011 2015 in Netherlands was analyzed. linked data from Dutch register...
Background: Culture remains the gold standard in diagnosis of bacterial infection, but molecular biological techniques have yielded promising results. In this study, we validated a combined polymerase chain reaction and reverse line blot hybridization protocol for identifying musculoskeletal infections. Methods: Samples were obtained from seventy-six patients undergoing orthopaedic surgery various aseptic septic indications. The infection was based on review all available clinical culture...
It is unknown whether the treatment effects of partial meniscectomy and physical therapy differ when focusing on activities most valued by patients with degenerative meniscal tears.To compare in a tear, patients' important functional limitations as outcome.Randomized controlled trial; Level evidence, 1.This study part Cost-effectiveness Early Surgery versus Conservative Treatment Optional Delayed Meniscectomy for Patients over 45 years non-obstructive tears (ESCAPE) trial, multicenter...
Background and purpose — Dislocation is the leading reason for early revision surgery after total hip arthroplasty (THA). The dual-mobility (DM) cup was developed to provide more stability mechanically reduce risk of dislocation. Despite increased use DM cups, high-quality evidence their (cost-)effectiveness lacking. primary objective this randomized controlled trial (RCT) investigate whether there a difference in number dislocations following THA, using posterolateral approach, with...
Background: Treatment outcomes in studies on prosthetic joint infection are generally assessed using a dichotomous outcome relating to treatment success or failure. These measures neither include patient-centred including function and quality of life, nor do they account for adverse effects treatment. A desirability ranking (DOOR) measure can these factors has previously been proposed validated other serious infections. We aimed develop novel DOOR infections (PJIs). Methods: The Delphi...
hip
Marker-by-treatment analyses are promising new methods in internal medicine, but have not yet been implemented orthopaedics. With this analysis, specific cut-off points may be obtained, that can potentially identify whether meniscal surgery or physical therapy is the superior intervention for an individual patient. This study aimed to introduce a novel approach orthopaedic research relevant treatment selection markers affect outcome following patients with degenerative tears.Data were...
Background and purpose: Ceramic liners may reduce early stability of uncemented acetabular components due to higher stiffness. However, the bone ingrowth capacities porous trabecular titanium might compensate for this effect. This prospective randomized trial quantifies migration patterns Delta-TT cup, compares polyethylene ceramic liners.Patients methods: Patients undergoing primary total hip arthroplasty with cup femoral stem head were a (n = 25) or 28) liner. Radiostereometric analysis...