A5068698964- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Hip disorders and treatments
- Infectious Diseases and Tuberculosis
- Bone and Joint Diseases
- Infective Endocarditis Diagnosis and Management
- Shoulder Injury and Treatment
- Cardiac Valve Diseases and Treatments
- Knee injuries and reconstruction techniques
- Hip and Femur Fractures
- Osteoarthritis Treatment and Mechanisms
- Antimicrobial Resistance in Staphylococcus
- Pelvic and Acetabular Injuries
- Bone health and osteoporosis research
- Musculoskeletal synovial abnormalities and treatments
- Bacterial Identification and Susceptibility Testing
- Surgical site infection prevention
- Spinal Fractures and Fixation Techniques
- Rheumatoid Arthritis Research and Therapies
- Acute Myocardial Infarction Research
- Bone Tumor Diagnosis and Treatments
- Venous Thromboembolism Diagnosis and Management
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
Yokohama City University Medical Center
2019-2025
Yokohama City University
2016-2025
Yokohama City University Hospital
2023
Jyoban Hospital
2023
Orthopedic One
2017
United Nations
2014
Cleveland Clinic
2005-2010
Cleveland Foundation
2007-2008
Zeria Pharmaceutical (Japan)
1999-2001
Polymerase chain reaction (PCR) assays have been used to detect bacteria adherent failed orthopaedic implants, but some PCR had problems with probable false-positive results. We a combination of Staphylococcus species-specific and universal followed by DNA sequencing identify on implants retrieved from 52 patients (92 implants) at revision arthroplasty. addressed two questions in this study: (1) Is method able show the existence bacterial presumed aseptic loosed implants?; (2) What...
Several studies suggest that histologic findings from tissues obtained at revision arthroplasty for failed metal-on-metal (MOM) total hip implants may reflect an immune reaction to particles or ions in some patients. However, only a limited number of cases without MOM were reported as controls those studies.The purpose this study is better define the extent and distribution morphologic features attributed sampled surgery nonMOM THA.As part multicenter, prospective study, we reviewed 612...
Recent studies have reported the acceleration of subchondral bone remodeling during development osteoarthritis (OA). However, it is not possible to evaluate such molecular abnormalities using conventional radiographic techniques. We applied 18F-fluoride PET analysis painful or dysplastic hips at various stages OA and then compared this with findings clinical findings.A consecutive series 65 joints from 48 patients (average age, 40 years; range, 19-72 years) a hip joint complaint were...
Abstract Introduction: Despite secondary FAI after pelvic osteotomy for dysplasia has recently been recognized, surgical strategy not established. We have experienced computer-assisted hip arthroscopic osteochondroplasty rotational acetabular osteotomy. It is essential to identify the resection region before and during surgery. introduce preoperative CT-based virtual surgery CT-guide Method: Firstly, apply a 3D bone model based on patient-specific CT using Zed Hip (Lexi, Tokyo). A dynamic...
ABSTRACT A real-time PCR assay that uses two fluorescence resonance energy transfer probe sets and targets the tuf gene of staphylococci is described here. One set detects Staphylococcus genus, whereas other specific for aureus . hundred thirty-eight cultured isolates, which contained 41 isolates representing at least nine species, 100 positive blood cultures gram-positive cocci in clusters were tested. This was 100% sensitive detection genus S.
Abstract Objective To examine the effects of basic fibroblast growth factor (bFGF) gene–transduced chondrocytes on repair articular cartilage defects. Methods LacZ gene or bFGF was transduced into primary isolated rabbit with use a recombinant adeno‐associated virus (AAV) vector. These gene‐transduced were embedded in collagen gel and transplanted full‐thickness defect patellar groove rabbit. The efficiency transduction assessed according to percentage LacZ‐positive cells among total number...
Biofilms are complex microenvironments produced by microorganisms on surfaces. Ultrasonication disrupts biofilms and may make the microorganism or its DNA available for detection. We determined whether ultrasonication could affect our ability to detect bacteria adherent a metal substrate. A biofilm-formative Staphylococcus aureus strain was used an in vitro implant infection model (biofilm-formative condition). quantitative culture real time-polymerase chain reaction determine influence of...
Purpose: The preoperative differentiation of aseptic and septic loosening following a total hip arthroplasty (THA) remains challenging issue for clinicians to which several molecular imaging techniques have been applied. In our current study, we used F-18 fluoride positron emission tomography (PET) evaluate THA cases with stable, or loosened implants assess the possibility differentiating these clinical settings using novel uptake-type classification approach. Materials Methods: A 65 joints...
The imaging diagnosis of osteoarthritis (OA) the hip, especially in its early stages, is a technically challenging but essential aspect our increased understanding pathophysiology this disorder. We recently applied 18F-fluoride PET for detection abnormal bone turnover early-stage OA. In current study, we have compared diagnostic and analytical capabilities MRI modalities hip OA patient series.A total 85 joints, including hips at various stages as well painful, dysplastic, normal...
The mechanism underling bone mineral density (BMD) loss that occurs in the femur after total hip arthroplasty (THA) remains unknown. We compared equivalent stress and strain energy (SED) to BMD THA using subject-specific finite element analyses. Twenty-four patients who had undergone primary cementless were analysed. was measured dual-energy X-ray absorptiometry (DEXA) at 1 week 3, 6 12 months THA. Seven regions of interest (ROIs) defined accordance with Gruen's system (ROIs 1–7). Computed...
Scapular fractures are rare injuries, whereas rib more common. frequently associated with fractures, which may lead to significant respiratory compromise. While surgical fixation has demonstrated benefits for both scapular and simultaneous using a single approach is not widely practiced. A 54-year-old male sustained right body fracture (AO 14B1) multiple following crush injury. Due severe pain prolonged mechanical ventilation, was performed on post-injury day three video-assisted...
Abstract Background: The shelf acetabuloplasty has received renewed attention as a minimally invasive, joint preservation surgery for developmental dysplasia of the hip joint. However, there been little scientific validation optimal location in terms stress reduction. Clinical Questions: (1) Where is successful reduction to acetabulum? (2) Are any patient characteristics that indicate limitations make it difficult obtain load distribution? Patients and Methods: Preoperative computed...