A5065699717- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Rheumatoid Arthritis Research and Therapies
- Orthopedic Infections and Treatments
- Spondyloarthritis Studies and Treatments
- Heart Rate Variability and Autonomic Control
- Osteoarthritis Treatment and Mechanisms
- Cardiovascular and exercise physiology
- Knee injuries and reconstruction techniques
- Autoimmune and Inflammatory Disorders Research
- Anesthesia and Pain Management
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Hip disorders and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Opioid Use Disorder Treatment
- Obesity, Physical Activity, Diet
- Cardiovascular Function and Risk Factors
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cardiac pacing and defibrillation studies
- Musculoskeletal pain and rehabilitation
- Cardiac, Anesthesia and Surgical Outcomes
- Non-Invasive Vital Sign Monitoring
- Lower Extremity Biomechanics and Pathologies
Leiden University Medical Center
2016-2025
Leiden University
2006-2024
Mount Sinai Hospital
2023
University of Toronto
2023
Sheffield Teaching Hospitals NHS Foundation Trust
2023
Izmir Kâtip Çelebi University
2023
Mahidol University
2023
Gigtforeningen
2023
Schlosspark-Klinik
2023
German Rheumatism Research Centre
2023
To compare the effectiveness of longstanding (>52 weeks), supervised exercise therapy with usual care in adults rheumatoid arthritis (RA) and severe functional limitations.
Background There is growing evidence that disturbances in maternal metabolism and, subsequently, intrauterine conditions affect foetal metabolism. Whether this has metabolic consequences offspring later life not fully elucidated. We investigated whether pre-pregnancy body mass index (pBMI) associated with offspring's adiposity at age 5–6 years and association mediated by the mother's lipid profile during early pregnancy. Methods Data were derived from a multi-ethnic birth cohort, Amsterdam...
The arterial baroreflex buffers slow (<0.05 Hz) blood pressure (BP) fluctuations, mainly by controlling peripheral resistance. Baroreflex sensitivity (BRS), an important characteristic of control, is often noninvasively assessed relating heart rate (HR) fluctuations to BP fluctuations; more specifically, spectral BRS assessment techniques focus on the BP-to-HR transfer function around 0.1 Hz. Skepticism about relevance characterize baroreflex-mediated buffering based two considerations: 1)...
Adverse intrauterine conditions can program hypertension. Because one of the underlying mechanisms is thought to be cardiac autonomic balance, we investigated association between prepregnancy body mass index (BMI) and blood pressure indicators balance in child at age 5 6 years. Also was whether these associations were mediated by standardized birth weight BMI. Pregnant women (n=3074) participating Amsterdam Born Children their Development study completed a questionnaire gestational week 14....
Purpose To investigate the reliability and validity of SQUASH physical activity (PA) questionnaire in a multi-ethnic population living Netherlands. Methods We included participants from HELIUS study, population-based cohort study. In this study we Dutch (n = 114), Turkish 88), Moroccan 74), South-Asian Surinamese 98) African 91) adults, aged 18–70 years. The was self-administered twice to assess test-re-test (mean interval 6–7 weeks) wore an accelerometer heart rate monitor (Actiheart)...
Current development of novel systemic agents requires identification and monitoring extensive Tenosynovial Giant Cell Tumours (TGCT). This study defines TGCT extension on MR imaging to classify severity.In part one, six parameters were defined by field-experts assess disease images: type TGCT, articular involvement, cartilage-covered bone invasion, involvement muscular/tendinous tissue, ligaments or neurovascular structures. Inter- intra-rater agreement calculated using 118 scans. In two,...
Background: For a subgroup of people with rheumatoid arthritis (RA) and severe disability, insight into their limitations is crucial for adequate treatment. Aim: To describe the extent nature functional in RA disability to explore associations patient characteristics, disease outcome measures. Methods: Baseline data 215 participants an RCT on (cost-)effectiveness longstanding physiotherapy were used. Functional assessed Health Assessment Questionnaire Disability Index (HAQ-DI). The total...
To identify global differences in the use of suppressive antimicrobial therapy (SAT) management prosthetic joint infection (PJI).
Aims We estimated the prevalence of people living with at least one hip, knee, or shoulder arthroplasty in Netherlands. Methods included first hip (n = 416,333), knee 314,569), 23,751) each patient aged ≥ 40 years between 2007 and 2022 (hip/knee) 2014 (shoulder) from Dutch Arthroplasty Register (LROI). Data on size population were obtained Statistics Annual incidences deaths since 2010, 2015, observed LROI. before those using Poisson regression analyses parametric survival models based a...
Background: Total hip arthroplasty (THA) is rarely performed in pediatric patients and can be challenging children because of smaller-sized joints, pathomorphological changes around the hip, residual growth, higher physical demands. Literature on THA outcomes this unique population scarce. We aimed to describe characteristics who underwent THA, 5- 10-year implant survival, risk factors for revision, results patient-reported outcome measures (PROMs) a large national cohort. Methods: Primary...
Aims To develop a multidisciplinary health research agenda (HRA) utilizing expertise from various disciplines to identify and prioritize evidence uncertainties in orthopaedics, thereby reducing waste. Methods We employed novel, structured framework HRA. started by systematically collecting all stakeholders with an interest orthopaedic care, categorizing them into 13 sub-themes defined the Dutch Orthopaedic Association (NOV). Subsequently, modified two-phased Delphi study (two rounds per...
Studies have shown that osteoarthritis patients who underwent a primary total hip or knee arthroplasty (THA/TKA) experience better survival than the general population, yet there is limited evidence explaining this counter-intuitive difference. We investigated whether also present in Netherlands and to what extent it could be explained by patient selection effect, whereby with more favorable health socioeconomic status (SES) are likely receive THA/TKA. In registry-based study, we compared...
Abstract Objective Benefits of physical activity (PA) on sleep in people with axial SpondyloArthritis (axSpA) are largely unknown. Our aim is to explore the relationships between PA and both a group level an individual using Wearable Activity Trackers (WATs) machine learning. Methods A sample 64 axSpA participants received WAT monitor their sleep. Participants more than 30 days data duration were included analyses. Spearman’s correlation learning technique Subgroup Discovery used determine...
Background and purpose: This study introduces an innovative research design in the field of orthopedics, using a target trial emulation approach. We aimed to assess causal effects total hip arthroplasty (THA) compared with nonoperative treatment reducing patient-reported disability at 3 months patients osteoarthritis, real-world data.Methods: emulated data 2 Dutch hospitals between April 2020 January 2022. Patients diagnosed osteoarthritis eligible for primary THA were included study. During...
Background and aim The oxygen uptake efficiency slope (OUES) is a novel measure of cardiopulmonary reserve. OUES measured during an exercise test, but it independent the maximally achieved intensity. It has higher prognostic value in chronic heart failure (CHF) than other test-derived variables such as V.O2peak or V.E/V.CO2 slope. Exercise training improves CHF patients. We hypothesized that also OUES. Methods results studied 34 New York Heart Association (NYHA) class II–III patients who...
Background A causal relationship between maternal obesity and offspring asthma is hypothesized to begin during early development, but no underlying mechanism for the found association identified. We quantitatively examined mediation by body mass index (BMI) in of pre-pregnancy BMI on risk wheezing first 7–8 years life a large Amsterdam born birth cohort. Methods For 3185 mother-child pairs, mothers reported outcomes "ever being diagnosed with asthma" "wheezing past 12 months" questionnaires....
Background In adults, increased sympathetic and decreased parasympathetic nervous system activity are associated with a less favorable metabolic profile. Whether this is already determined at early age unknown. Therefore, we aimed to assess the association between autonomic activation profile its components in children of 5–6 years. Methods Cross-sectional data from an apparently healthy population (within ABCD study) were collected years 1540 children. Heart rate (HR), respiratory sinus...
Background: Osteoarthritis (OA) severity as demonstrated by preoperative radiographs and pain play an important role in the indication for total knee arthroplasty (TKA). We investigated whether radiographic evidence of OA modified effect self-reported on postoperative function 1 2 years after TKA OA. Methods: Data from Longitudinal Leiden Orthopaedics Outcomes Study (LOAS), a multicenter cohort study outcomes TKA, were used. was assessed radiographically with Kellgren Lawrence (KL) score...
Background and purpose — A lifetime perspective on revision risks is needed for optimal timing of arthroplasty in osteoarthritis (OA) patients, weighing the benefit total hip arthroplasty/total knee (THA/TKA) against risk revision, after which outcomes are less favorable. Therefore, we provide population-based 10-year cumulative stratified by joint, sex, fixation type, age. Patients methods Data from Dutch Arthroplasty Register (LROI) was used. Primary THAs TKAs OA between 2007 2018 were...
Anxiety, depression and greater pain intensity before total knee arthroplasty (TKA) may increase the probability of revision surgery for remaining symptoms even without clear pathology or technical issues. We aimed to assess whether preoperative anxiety/depression are associated with TKA less indications.Less indications were defined after a Delphi process in which consensus was reached among 59 orthopaedic experts. performed cox regression analyses on primary patients registered Dutch...