A5107962952- Osteoarthritis Treatment and Mechanisms
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Pituitary Gland Disorders and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Growth Hormone and Insulin-like Growth Factors
- Oral and Maxillofacial Pathology
- Rheumatoid Arthritis Research and Therapies
- Bone and Joint Diseases
- Total Knee Arthroplasty Outcomes
- Soft tissue tumor case studies
- TGF-β signaling in diseases
- Bone health and treatments
- Knee injuries and reconstruction techniques
- Bone health and osteoporosis research
- Orthopaedic implants and arthroplasty
- Cardiac tumors and thrombi
- Orthopedic Infections and Treatments
- Digital Radiography and Breast Imaging
- Cancer Diagnosis and Treatment
- Connective tissue disorders research
- Inflammatory mediators and NSAID effects
- Orthopedic Surgery and Rehabilitation
- Mast cells and histamine
- Urticaria and Related Conditions
Leiden University Medical Center
2016-2025
Leiden University
2010-2021
Loyola University Medical Center
2009-2018
Research Institute of Radiology
2017
Quality Research
2017
Haga Hospital
2013
Amsterdam UMC Location Vrije Universiteit Amsterdam
2012
Hospital for Special Surgery
2012
Amsterdam University Medical Centers
2012
Memorial Sloan Kettering Cancer Center
2012
There are insufficient data on the effects of long-term intensive exercise in patients with rheumatoid arthritis (RA). We undertook this randomized, controlled, multicenter trial to compare effectiveness and safety a 2-year program (Rheumatoid Arthritis Patients In Training [RAPIT]) those physical therapy (termed usual care [UC]).Three hundred nine RA were assigned either RAPIT or UC. The primary end points functional ability (assessed by McMaster Toronto [MACTAR] Patient Preference...
IN systemic mastocytosis, an abnormal proliferation of mast cells infiltrates the skin, bone marrow, spleen, liver, and lymph nodes.1 2 3 The release mast-cell mediators such as histamine causes attacks, with flushing, itching, headache, gastrointestinal symptoms, even vascular collapse syncope.1 Although life expectancy most patients is good, some have a malignant form disease, aggressive in which there marked infiltration organs by rapidly progressive downhill course.1 presence leukemic...
A number of risk factors based upon mostly retrospective surgical data, have been formulated in order to identify impending pathological fractures the femur from low-risk metastases. We followed up patients taking part a randomised trial radiotherapy, prospectively, determine if these were effective predicting fractures. In 102 with 110 femoral lesions, 14 occurred during follow-up. The studied increasing pain, size lesion, radiographic appearance, localisation,...
Osteoarthritis [MIM 165720] is a common late-onset articular joint disease for which no pharmaceutical intervention available to attenuate the cartilage degeneration. To identify new osteoarthritis susceptibility locus, genome-wide linkage scan and combined association analysis were applied 179 affected siblings four trios with generalized (The GARP study). We tested, confirmation by association, 1478 subjects who required replacement 734 controls in UK population. Additional replication was...
The purpose of this study was to evaluate clinical symptoms and radiographic features that allow radiologists differentiate between enchondroma central grade 1 chondrosarcoma. Such differentiation is important because differences in management.Clinical location size 35 enchondromas 43 chondrosarcomas were analyzed. Radiographic assessed independently by three observers. chi-square test linear discriminant analysis used identify with discriminating strength. Kappa values calculated validate...
Objective. To get a better understanding of inflammatory pathways active in the osteoarthritic (OA) joint, we characterized and compared cells synovium infrapatellar fat pad (IFP) patients with knee OA. Methods. Infiltrating immune were by flow cytometry 76 OA (mean age 63.3, 52% women, median body mass index 28.9) from whom synovial tissue (n = 40) IFP 68) samples obtained. Pain was assessed visual analog scale (VAS; 0–100 mm). Spearman rank correlations linear regression analyses adjusted...
To establish the prevalence of osteoporosis, vertebral fractures (VFs), and non-VFs in acromegaly patients with long-term controlled disease factors potentially influencing fracture risk.Case-control study. Patients measurements Eighty-nine (46% male, mean age: 58 years) were included. We studied VFs non-VFs, bone mineral density (BMD), markers turnover. In 48 patients, BMD assessment was also obtained 7 years prior to current compare VF prevalence, data from a sample Dutch population...
Introduction Although Total Hip and Knee Replacements (THR/TKR) improve Health-Related Quality of Life (HRQoL) at the group level, up to 30% patients are dissatisfied after surgery due unfulfilled expectations. We aimed assess whether pre-operative radiographic severity osteoarthritis (OA) is related improvement in HRQoL THR or TKR, both population individual level. Methods In this multi-center observational cohort study, OA requiring TKR was measured 2 weeks before 2–5 years follow-up,...
In active acromegaly, pathologically elevated GH and IGF-1 levels are associated with increased bone turnover a high mass, the latter being sustained after normalization of values. cross-sectional study design, we have previously reported prevalence vertebral fractures (VFs) about 60% in patients controlled despite normal mean mineral density (BMD) Whether these occur during acromegaly phase or remission is achieved not known.Our objective was to natural progression VFs contributing risk...
Objective To assess the impact of different subsets symptomatic hand osteoarthritis (OA) on pain and disability. Methods From 308 patients with OA a group carpometacarpal joint (CMCJ) symptoms only (group I, n=20) was identified as well groups at interphalangeal joints (IPJs) II, n=138), both sites III, n=150). Hand function, assessed AUSCAN, were compared between using linear mixed models. Radiological Kellgren–Lawrence grading scale. Results Mean (SD) AUSCAN scores for II III 23.1 (11.7),...
The identified osteoarthritis (OA) susceptibility genes are mainly active in skeletal development and could thus affect joint geometry. Because nonoptimal geometry is a risk factor for the of OA, we investigated if how path that leads from to OA hip influenced by these genes.The shape hips subjects Genetics, Osteoarthritis Progression Study, consisting sibling pairs with symptomatic at multiple locations, was quantified applying statistical model radiographs. Shape aspects (modes) were...
To determine possible patterns of synovitis on contrast-enhanced magnetic resonance imaging (CE-MRI) and its relation to pain severity in patients with radiographic knee osteoarthritis (OA).In total, 86 (mean age 62 years, 66% women, median body mass index 29 kg/m(2) ) symptomatic OA (Kellgren/Lawrence score 3) were included. T1-weighted, gadolinium-chelate-enhanced MRI fat suppression was used semiquantitatively the extent at 11 sites (total range 0-22). Self-reported assessed 3...
Osteoid osteoma and osteoblastoma are bone-forming tumors shown to harbor FOS (87%) FOSB (3%) rearrangements. The aim was evaluate the immunohistochemical expression of in these comparison other bone tumors, influence decalcification, correlate findings with underlying genetic alteration using fluorescence situ hybridization (FISH). Immunohistochemistry whole sections performed on osteoid (n=23), (n=22), osteoblastoma-like osteosarcoma (n=3), reactive proliferative (n=11) lesions....
Abstract Objective Patients with rheumatoid arthritis (RA) are more at risk for the development of osteoporosis and osteoporotic fractures than their healthy peers. In this randomized, controlled, multicenter trial, effectiveness a 2‐year high‐intensity weight‐bearing exercise program (the Rheumatoid‐Arthritis‐Patients‐In‐Training [RAPIT] program) on bone mineral density (BMD) was compared usual care physical therapy, modalities associated changes in BMD were determined. Methods Three...
To evaluate the prevalence and rheumatological radiological characteristics of arthropathy in patients after long-term cure acromegaly comparison with age-matched controls.Case-control study.We compared 89 adequate biochemical control (mean 14 years) 67 controls.Study parameters were results symptom questionnaires, structured physical examination radiographs spine, hip, knee hand. The diagnosis osteoarthritis was based on a) determined by Kellgren Lawrence b) clinical American College...