A5005075224- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Oral and Maxillofacial Pathology
- Cardiac tumors and thrombi
- Neuroblastoma Research and Treatments
- Neurofibromatosis and Schwannoma Cases
- Cancer Diagnosis and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Vascular Tumors and Angiosarcomas
- Medical Imaging and Pathology Studies
- Soft tissue tumor case studies
- Lymphoma Diagnosis and Treatment
- Renal cell carcinoma treatment
- Tumors and Oncological Cases
- Histiocytic Disorders and Treatments
- Orthopedic Infections and Treatments
- Psoriasis: Treatment and Pathogenesis
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Fungal Infections and Studies
- Viral-associated cancers and disorders
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Eosinophilic Disorders and Syndromes
Hôpital Cochin
2016-2025
Université Paris Cité
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Délégation Paris 5
2013-2025
Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale
2007-2023
Sorbonne Paris Cité
2011-2022
Hôpital Saint-Vincent-de-Paul
2020-2021
Maternité Port Royal
2021
Inserm
2002-2020
Centre National de la Recherche Scientifique
2002-2020
Sarcoma represents a highly heterogeneous group of tumours. We report here the first unbiased and systematic search for gene fusions combined with unsupervised expression analysis series 184 small round cell sarcomas. Fusion genes were detected in 59% samples, half them being observed recurrently. identified biologically homogeneous groups tumours such as CIC-fused (to DUX4, FOXO4 or NUTM1) BCOR-rearranged (BCOR-CCNB3, BCOR-MAML3, ZC3H7B-BCOR, BCOR internal duplication) tumour groups....
Background Since 2010, nationwide networks of reference centers for sarcomas (RREPS/NETSARC/RESOS) collected and prospectively reviewed all cases connective tumors intermediate malignancy (TIM) in France. Methods The incidence sarcoma or TIM (2013–2016) was measured using the 2013 WHO classification confirmed by a second independent review expert pathologists. Simple clinical characteristics, yearly variations correlation with published trials are presented analyzed. Results Over 150...
EBV-induced gene 3 (EBI3) can associate with p28 to form the heterodimeric cytokine IL-27, or p35 subunit of IL-12 EBI3/p35 heterodimer, recently named IL-35. In mice, IL-35 has been shown be constitutively expressed by CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg cells) and suggested contribute their suppressive activity. this study, we investigated whether human Treg express Double-staining analysis thymuses showed that neither Foxp3(+) nor CD25(+) coexpressed EBI3. Similarly, present in...
The French phase 3 trial (OS 2006) testing zoledronic acid, an osteoclast inhibitor, with chemotherapy and surgery did not improve the outcome of patients osteosarcoma (OS). To understand this unexpected result, presence infiltrating immune cells was investigated in 124 pre-therapeutic biopsies enrolled trial. percentage CD68/CD163 tumor-infiltrating macrophages (TAMs), CD8+ lymphocytes, osteoclasts, PD1/PDL-1 checkpoint were assessed by immunohistochemistry. M1/M2 macrophage polarization...
Chondrosarcomas are primary cancers of cartilaginous tissue with highly contrasting prognoses. These tumors defined by recurrent mutations in the IDH genes and other genetic alterations including inactivation CDKN2A COL2A1; however, these have no clinical value. Here we use multi-omics molecular profiles from a series cartilage find an mRNA classification that identifies two subtypes chondrosarcomas balance tumor differentiation cell cycle activation. The microRNA reveals importance loss...
We identified prognostic factors of papillary renal cell carcinoma (PRCC) types 1 (PRCC1) and 2 (PRCC2).Between 1985 1998, 759 patients underwent surgery for carcinoma, whom 88 (11.6%), including 69 males 19 females with a mean age 61.8 years (range 21.3 to 85.9) who had PRCC. Multifocality was defined as or greater tumors separated by 10 mm greater. Small basophilic cells PRCC1 large eosinophilic PRCC2. Mean followup in 79 cases 71.1 months 196.6). Survival rates were calculated statistical...
Abstract Interleukin (IL)‐27 is a newly described member of the IL‐12 family. It heterodimeric cytokine composed two subunits, p28 and Epstein–Barr virus‐induced gene 3 (EBI3). In vitro studies have shown that IL‐27 mainly produced by activated monocytes dendritic cells. induces proliferation naïve CD4‐positive T cells synergizes with for interferon‐γ (IFN‐γ) production. Knock‐out mice receptor (WSX‐1/TCCR) impaired Th1 responses form abnormal granulomas when injected bacillus...
Extra-abdominal desmoid tumors are rare, locally aggressive neoplasms without metastatic potential. There is no clear consensus regarding their optimal management. The disappointing results of current treatments and the ability extra-abdominal to spontaneously stabilize have increasingly drawn interest toward conservative objective this study was evaluate a wait-and-see policy as first-line management for tumors.This two-center retrospective involved fifty-five patients with histologically...
Dedifferentiated liposarcoma (DDLPS) has been defined as a tumor composed of well-differentiated associated with nonlipogenic undifferentiated sarcoma and is genetically characterized by 12q13-15 amplicon MDM2 amplification. Some peripheral (extremities, trunk wall, head/neck) pleomorphic sarcomas (UPS) without areas present an We addressed whether they are true DDLPS or not. compared the clinical data, histologic status (immunohistochemistry [IHC], fluorescence in situ hybridization...
Abstract IL-27 is a novel heterodimeric cytokine of the IL-12 family that plays an important role in regulation T cell responses. Its on human B cells has not been previously studied. In this study, we show both chains receptor complex, IL-27R and gp130, are constitutively expressed at surface naive memory tonsillar cells, induced germinal center following CD40 stimulation. strong STAT1 STAT3 phosphorylation, whereas it moderate low activation cells. T-bet expression stimulated by or Ig...
We describe diagnostic and therapeutic characteristics, long-term followup of collecting (Bellini) duct carcinoma.Ten patients underwent surgery, including radical nephrectomy in 9 partial 1, for carcinoma diagnosed by histological immunohistochemical criteria.Collecting carcinoma, which represented 1.3% renal cell carcinomas between 1986 1999, developed at a mean patient age 66.2 years (range: 50.7 to 81). It was detected clinically but never because macroscopic hematuria. Mean tumor size...