A5085513812- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Airway Management and Intubation Techniques
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Acute Kidney Injury Research
- Spine and Intervertebral Disc Pathology
- Shoulder Injury and Treatment
- Anesthesia and Neurotoxicity Research
- Mechanical Circulatory Support Devices
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Nausea and vomiting management
- Respiratory Support and Mechanisms
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hip and Femur Fractures
- Pain Mechanisms and Treatments
- Venous Thromboembolism Diagnosis and Management
- Long-Term Effects of COVID-19
- Pediatric Pain Management Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Pain Management and Opioid Use
- Trauma Management and Diagnosis
Centre Hospitalier Universitaire de Toulouse
2016-2025
Hôpital Purpan
2005-2024
Hôpital Rangueil
2013-2024
Université Toulouse III - Paul Sabatier
2014-2024
Université de Toulouse
2015-2024
Inserm
2010-2024
Imation (United States)
2010-2024
RESTORE
2021-2024
Hôpital Paule de Viguier
2005-2024
Université de Lille
2022-2024
Using the intubation difficulty scale (IDS), we sought to confirm that obese patients are more difficult intubate than lean patients. We assessed classical bedside tests and included neck circumference.We prospectively compared incidence of tracheal in 70 [body mass index (BMI) > or = 30 kg/m(2)] 61 (BMI < kg/m(2)). The IDS scores, categorized as (IDS 5) not 5), patient data, were between Preoperative measurements [BMI, circumference (at level thyroid cartilage), width mouth opening,...
This study was design to investigate the prognostic value for death at day-28 of lactate course and clearance during first 24 hours in Intensive Care Unit (ICU), after initial resuscitation. Prospective, observational one surgical ICU a university hospital. Ninety-four patients hospitalized severe sepsis or septic shock were included. In this cohort, we measured blood concentration admission (H0) H6, H12, H24. Lactate calculated as followed: [(lactateinitial - lactatedelayed)/...
The French phase 3 trial (OS 2006) testing zoledronic acid, an osteoclast inhibitor, with chemotherapy and surgery did not improve the outcome of patients osteosarcoma (OS). To understand this unexpected result, presence infiltrating immune cells was investigated in 124 pre-therapeutic biopsies enrolled trial. percentage CD68/CD163 tumor-infiltrating macrophages (TAMs), CD8+ lymphocytes, osteoclasts, PD1/PDL-1 checkpoint were assessed by immunohistochemistry. M1/M2 macrophage polarization...
The cecal ligation and puncture (CLP) model, a gold standard in sepsis research, is associated with an important variability mortality. While the number of punctures needle size well described CLP animal studies, length often not. relationship between survival mice briefly reported literature; therefore, we devised investigation consequences three standardized lengths on mortality severity ensued sepsis.Male C57BL/6J underwent CLP. cecum was ligated at 5, 20, or 100 % its total further...
The world is currently facing an unprecedented healthcare crisis caused by the COVID-19 pandemic. objective of these guidelines to produce a framework facilitate partial and gradual resumption intervention activity in context group has endeavoured minimum number recommendations highlight strengths be retained 7 predefined areas: (1) protection staff patients; (2) benefit/risk patient information; (3) preoperative assessment decision on intervention; (4) modalities preanaesthesia...
Importance It is uncertain whether a rapid-onset opioid noninferior to neuromuscular blocker during rapid sequence intubation when used in conjunction with hypnotic agent. Objective To determine remifentanil blockers for intubation. Design, Setting, and Participants Multicenter, randomized, open-label, noninferiority trial among 1150 adults at risk of aspiration (fasting &amp;lt;6 hours, bowel occlusion, recent trauma, or severe gastroesophageal reflux) who underwent tracheal the...
Weaning from mechanical ventilation is associated with the presence of asynchronies between patient and ventilator. The main objective present study was to demonstrate a decrease in total number patient-ventilator invasively ventilated patients for whom difficulty weaning expected by comparing neurally adjusted ventilatory assist (NAVA) pressure support (PSV) modes. We performed prospective, non-randomized, non-interventional, single-center study. Thirty were included Each benefited an...
In Brief Aging and disease may make elderly patients particularly susceptible to hypotension during spinal anesthesia. We compared the hemodynamic effect of continuous anesthesia (CSA) small dose single injection (SA) regarding incidence hypotension. Seventy-four aged >75 yr undergoing surgical repair hip fracture were randomized into 2 groups 37 each. Group CSA received a anesthetic with titration 2.5 mg boluses every 15 min isobaric bupivacaine, while group SA 7.5 bupivacaine. The overall...
In Brief BACKGROUND: Spinal anesthesia in elderly patients is frequently associated with significant technical difficulties. Thus, we compared the classical midline approach to paramedian perform continuous spinal (CSA). METHODS: We prospectively studied 40 aged >75 yr who underwent open surgical repair of a hip fracture. These were randomly allocated one two groups: Group M: approach, and PM: approach. Patients positioned lateral decubitus receive CSA at L4-5 level. was considered...
Background: Effective postoperative analgesia is essential for early rehabilitation after surgery.Continuous wound infiltration (CWI) of local anesthetics has been proposed as an alternative to epidural (EA) during colorectal surgery.This prospective, double-blind trial compared CWI and EA in patients undergoing elective open surgery.Methods: Fifty consecutive were randomized receive or 48 h.In both groups, managed according Enhanced Recovery After Surgery recommendations.The primary outcome...
Abstract Introduction The aim of this study, performed in an intensive care unit (ICU) population with a normal serum creatinine, was to estimate urinary creatinine clearance (CL CR ) polytrauma patients (PT) through comparison non trauma (NPT). Methods This retrospective, observational study medical and surgical ICU university hospital. A total 284 were consecutively included. Two different groups studied: PT ( n = 144) NPT 140). Within the second week after admission ICU, renal function...
In ICU patients with normal serum creatinine (SCr), a state of increased renal drug excretion has been described (creatinine clearance ≥130 ml/min/1.73 m(2)), and named augmented (ARC). patients, the accuracy GFR estimates is insufficient. However, in clinical practice, physician not at one's disposal patient measured (CrCl) when prescribing. The primary objective this study was to assess 4 formulas estimate (Cockcroft-Gault (CG), Robert, sMDRD, CKD-EPI formulas) other covariates detect ARC...
Purpose: Extra Corporeal Membrane Oxygenation (ECMO) is used in cases of severe respiratory and/or circulatory failure over periods several days to weeks. Its circuitry requires a closely monitored anticoagulation therapy that empirically supported by activated clotting time (ACT)—a method often associated with large inter- and intraindividual variability. We aimed compare the measurement heparin activity ACT direct (anti-Xa) ECMO population. Methods: All patients treated venoarterial or...
The use of prothrombin complex concentrates and the role plasma concentration anticoagulants in management bleeding patients treated with direct oral are still debated. Our aim was to describe strategies outcomes severe events anticoagulants.We performed a prospective cohort study 732 dabigatran, rivaroxaban, or apixaban hospitalized for bleeding, included prospectively registry from June 2013 November 2015.Bleeding gastrointestinal intracranial 37% (212 732) 24% (141 cases, respectively....
Abstract Recent European Society of Parenteral and Enteral Nutrition guidelines highlighted the interest prevention, diagnosis treatment malnutrition in management coronavirus disease 19 (COVID-19) patients. The aim our study was to evaluate prevalence patients hospitalised for COVID-19. In a prospective observational cohort diagnosed according Global Leadership Initiative on Malnutrition (GLIM) two-step approach. Patients were divided into two groups malnutrition. Covariate selection...
ABSTRACT Background Before implementing individualized strategies to treat acute kidney injury (AKI), identifying clusters of patients with divergent pathophysiological mechanisms, diagnosis criteria or outcomes is the utmost importance. Here we studied sex-related molecular mechanisms in cardiac bypass (CBP) surgery developing AKI. Methods We compared characteristics 1170 referred for CBP using multivariate logistic regression and propensity score–based analysis. Performances candidate...
Background Anterior cruciate ligament reconstruction (ACLR) can cause severe postoperative pain. However, consensus regarding the most effective regional analgesia is lacking. We hypothesized that, compared with femoral triangle block (FTB) and local infiltration analgesia, adding an iPACK would decrease morphine consumption. Methods Patients scheduled for ACLR under general anesthesia were randomly allocated to FTB (n=45) or FTB+iPACK group (n=45). The primary outcome was cumulative oral...