Karim Asehnoune
A5070261387- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Immune Response and Inflammation
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Airway Management and Intubation Techniques
- Nosocomial Infections in ICU
- Hemodynamic Monitoring and Therapy
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Anesthesia and Pain Management
- Adrenal Hormones and Disorders
- Immune Cell Function and Interaction
- Pneumonia and Respiratory Infections
- Anesthesia and Sedative Agents
- Antibiotic Resistance in Bacteria
- Thermal Regulation in Medicine
- Family and Patient Care in Intensive Care Units
- Neurosurgical Procedures and Complications
- Renal function and acid-base balance
- Trauma and Emergency Care Studies
- Acute Kidney Injury Research
- Blood Pressure and Hypertension Studies
- NF-κB Signaling Pathways
Nantes Université
2016-2025
Centre d'Investigation Clinique de Nantes
2009-2025
Centre Hospitalier Universitaire de Nantes
2016-2025
Clinical Trial Investigators
2025
Inserm
2015-2024
Center for Research in Transplantation and Translational Immunology
2022-2024
Hotel Dieu Hospital
2013-2022
Institut de Transplantation Urologie en Nephrologie
2022
Alberta Health Services
2022
University of Alberta
2022
Septic shock is characterized by dysregulation of the host response to infection, with circulatory, cellular, and metabolic abnormalities. We hypothesized that therapy hydrocortisone plus fludrocortisone or drotrecogin alfa (activated), which can modulate response, would improve clinical outcomes patients septic shock.
Abstract Although oxidative stress has been thought to play a general role in the activation of NF-κB, involvement reactive oxygen species (ROS) facilitating nuclear translocation NF-κB neutrophils not described. In addition, mechanisms by which ROS modulate transcriptional activity response Toll-like receptor 4 (TLR4)-dependent signaling are well characterized. To examine these issues, oxidant-dependent events downstream TLR4 were investigated stimulated with LPS. Pretreatment antioxidants...
Difficult intubation in the intensive care unit (ICU) is a challenging issue.To develop and validate simplified score for identifying patients with difficult ICU to report related complications.Data collected prospective multicenter study from 1,000 consecutive intubations 42 ICUs were used of intubation, which was then validated externally 400 procedures 18 other internally by bootstrap on iterations.In multivariate analysis, main predictors (incidence = 11.3%) patient (Mallampati III or...
Background It is speculated that opioid-free anesthesia may provide adequate pain control while reducing postoperative opioid consumption. However, there currently no evidence to support the speculation. The authors hypothesized balanced anesthetic with dexmedetomidine reduces opioid-related adverse events compared remifentanil. Methods Patients were randomized receive a standard either intraoperative remifentanil plus morphine (remifentanil group) or (opioid-free group). All patients...
Objectives: To determine the prevalence of and risk factors for cardiac arrest during intubation in ICU, as well association ICU intubation–related with 28-day mortality. Design: Retrospective analysis prospectively collected data. Setting: Sixty-four French ICUs. Patients: Critically ill patients requiring ICU. Interventions: None. Measurements Main Results: During 1,847 procedures included, 49 arrests (2.7%) occurred, including 14 without return spontaneous circulation (28.6%) 35 (71.4%)....
Optimal transfusion strategies in traumatic hemorrhage are unknown. Reports suggest a beneficial effect of 4-factor prothrombin complex concentrate (4F-PCC) on blood product consumption.To investigate the efficacy and safety 4F-PCC administration patients at risk massive transfusion.Double-blind, randomized, placebo-controlled superiority trial 12 French designated level I trauma centers from December 29, 2017, to August 31, 2021, involving consecutive with transfusion. Follow-up was...
New evidence is available examining the use of corticosteroids in sepsis, acute respiratory distress syndrome (ARDS) and community-acquired pneumonia (CAP), warranting a focused update 2017 guideline on critical illness-related corticosteroid insufficiency.
Current guidelines suggest the introduction of early nutrition support within first 48 h admission to intensive care unit (ICU) for patients who cannot eat. In that context, we aimed describe practices in ICU and study association between (< h) patient mortality at day 28 (D28) using data from a multicentre prospective cohort.The 'French-Speaking Nutritional Survey' (FRANS) was conducted 26 ICUs France Belgium over 3 months 2015. Adult with predicted length stay > days were consecutively...
High mobility group box 1 (HMGB1) is a novel late mediator of inflammatory responses that contributes to endotoxin-induced acute lung injury and sepsis-associated lethality. Although frequent complication severe blood loss, the contribution HMGB1 organ system dysfunction in this setting has not been investigated. In study, was detected pulmonary endothelial cells macrophages under baseline conditions. After hemorrhage, addition positively staining macrophages, neutrophils expressing were...