Antonella Cotoia
A5024238922- Cardiac, Anesthesia and Surgical Outcomes
- Clinical Nutrition and Gastroenterology
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- COVID-19 and healthcare impacts
- Anesthesia and Neurotoxicity Research
- Hemodynamic Monitoring and Therapy
- Airway Management and Intubation Techniques
- Trauma and Emergency Care Studies
- Tracheal and airway disorders
- Anesthesia and Pain Management
- Electrolyte and hormonal disorders
- Nutrition and Health in Aging
- Antibiotic Use and Resistance
- Neonatal Respiratory Health Research
- Abdominal Surgery and Complications
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Sedative Agents
- Gut microbiota and health
- Advanced Glycation End Products research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Eicosanoids and Hypertension Pharmacology
- Cancer, Hypoxia, and Metabolism
University of Foggia
2016-2025
Ospedali Riuniti di Foggia
2018-2023
ORCID
2021
Université Libre de Bruxelles
2018-2021
University of Ferrara
2018
Complejo Hospitalario de Navarra
2016
University of Pittsburgh
2008-2012
Meropenem is a widely prescribed β-lactam antibiotic. exhibits maximum pharmacodynamic efficacy when given by continuous infusion to deliver constant drug levels above the minimal inhibitory concentration. Compared with intermittent administration, administration of meropenem may improve clinical outcomes.To determine whether reduces composite mortality and emergence pandrug-resistant or extensively drug-resistant bacteria compared in critically ill patients sepsis.A double-blind, randomized...
Abstract Background Muscle mass evaluation in ICU is crucial since its loss related with long term complications, including physical impairment. However, quantifying muscle wasting available bedside tools (ultrasound and bioimpedance analysis) must be more primarily understood. Bioimpedance analysis (BIA) provides estimates of phase angle (PA). The primary aim this study was to evaluate changes during the first 7 days after admission. Secondary aims searched for correlations between muscular...
We wished to explore the use, diagnostic capability and outcomes of bronchoscopy added noninvasive testing in immunocompromised patients. In this setting, an inability identify cause acute hypoxaemic respiratory failure is associated with worse outcome. Every effort should be made obtain a diagnosis, either alone or combined bronchoscopy. However, our understanding risks benefits remains uncertain.This was pre-planned secondary analysis Efraim, prospective, multinational, observational study...
Abstract Background Acetaminophen (APAP) overdose induces massive hepatocyte necrosis. Necrotic tissue releases high mobility group B1 (HMGB1), and HMGB1 contributes to liver injury. Even though blockade of does not protect against APAP-induced acute injury (ALI) at 9 h time point, the later points are studied role in APAP is unknown, it possible that neutralization might improve regeneration. This study aims test whether improves regeneration after overdose. Methods Male C57BL/6 mice were...
Abstract Background Specialized diets enriched with immune nutrients could be an important supplement in patients (pts) acute traumatic brain injury (TBI). Omega-3 and arginine may interact response microbiota. No data are available about the role of specialized modulating lung microbiota, little is known influence microbiota structure development ventilator-associated pneumonia (VAP) TBI pts. The aims this study to evaluate impact specific on variation pts developing VAP. Methods A cohort...
LPS-induced sepsis is a leading cause of acute kidney injury (AKI) in critically ill patients. LPS may induce CD80 expression podocytes with subsequent onset proteinuria, risk factor for progressive chronic disease (CKD) frequently observed after AKI. This study aimed to investigate the therapeutic efficacy removal decreasing albuminuria through reduction podocyte expression. Between January 2015 and December 2017, 70 consecutive patients Gram-negative sepsis-induced AKI were randomized...
<title>Abstract</title> <bold>Background.</bold> Lipopolysaccharide (LPS) is the main driver of sepsis-associated Acute Kidney Injury (SA-AKI) in Gram-Negative infections and its removal by Polymyxin-B Hemoadsorption (PMX-HA) has been evaluated clinical trials. Quorum Sensing (QS), diffusible signal molecules used Gram-Positive bacteria for intercellular communication, can interact with eukaryotic cells. Study aims were to evaluate: 1) presence QS blood urine septic patients their...
Abstract Background Patients with critical illness may present disease‐related malnutrition upon intensive care unit (ICU) admission. They are at risk of development and progression over the disease trajectory because inflammation, dysregulated metabolism, challenges feeding. Methods The Global Leadership Initiative on Malnutrition (GLIM) convened a panel 36 clinical nutrition experts to develop consensus‐based guidance statements addressing diagnosis during using modified Delphi approach...
During thoracic surgery in lateral decubitus, one lung ventilation (OLV) may impair respiratory mechanics and gas exchange. We tested a strategy based on an open approach (OLA) consisting recruitment immediately followed by decremental positive-end expiratory pressure (PEEP) titration to the best system compliance (CRS) separately quantified elastic properties of chest wall. Our hypothesis was that this would improve Further, we were interested documenting impact OLA partitioned mechanics....
Patients with critical illness may present disease-related malnutrition upon intensive care unit (ICU) admission. They are at risk of development and progression over the disease trajectory because inflammation, dysregulated metabolism, challenges feeding. The Global Leadership Initiative on Malnutrition (GLIM) convened a panel 36 clinical nutrition experts to develop consensus-based guidance statements addressing diagnosis during illness, using modified Delphi approach requirement ≥75%...
Emergence delirium (ED) is an acute change in cognition after general anesthesia (GA) occurring operative room, recovery room or postanesthesia care. The automated propofol-remifentanil titration by Bispectral Index (BIS) (AutoTIVA) avoids period of deep (BIS<40) and could potentially decrease the ED. aim this study was to evaluate ED surgical patients under AutoTIVA, manual (ManualTIVA) volatile BIS-guided GA. Moreover, we aimed age-related postoperative Mini-Mental State Examination (MMSE)...
During laparoscopy, respiratory mechanics and gas exchange are impaired because of pneumoperitoneum atelectasis formation. We applied an open lung approach (OLA) consisting in recruitment followed by a decremental positive-end expiratory pressure (PEEP) trial to identify the level PEEP corresponding highest compliance system (best PEEP). Our hypothesis was that this would improve both oxygenation without hemodynamic impairment.We studied twenty patients undergoing laparoscopic...
Background . The aim of this study was to investigate the effects listening Tibetan music on anxiety and endocrine, autonomic, cognitive responses in patients waiting for urologic surgery. Methods Sixty surgery were enrolled study. They randomized (M) control (C) groups. M group listened a low-frequency 30 min (T 0 –T ) through headphones, C wore headphones with no sound. State Trait Anxiety Inventory Questionnaire (STAI) Y-1 administered at T Normalized low (LFnu) high frequencies (HFnu)...
We tested the hypothesis that infusion of a small volume drag-reducing polymer (DRP) solution can prolong survival in rats subjected to lethal hemorrhagic shock (HS; shed 51% estimated blood volume) absence complete resuscitation with fluids or blood. In this set experiments, we used newly designed mixture hyaluronic acid (molecular weight, approximately 2.0 x 10 d; 0.4 mg/mL) and polyethylene oxide 4 0.05 dissolved sterile phosphate-buffered saline. Anesthetized were volume-controlled HS....
Most data in the literature report reduced coagulation activities first few days of life with respect to adults and effects these differences must be considered when diagnosing treating hemostatic disorders. The management pediatric population is further complicated by lack age-related reference values unreliability currently-used tests, while an accurate interpretation results required reduce cases inappropriate investigation. Thromboelastography (TEG®) a point-of-care test that provides...
While gastrointestinal (GI) dysfunction is commonly encountered among critically ill patients, a uniform prospectively validated scoring system lacking. The present study aims to validate the recently developed Gastrointestinal Dysfunction Score (GIDS) in multicenter, prospective cohort of consecutive adult patients admitted intensive care units (ICU).