A5069069103- Cardiac, Anesthesia and Surgical Outcomes
- Sepsis Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Anesthesia and Sedative Agents
- Airway Management and Intubation Techniques
- Hip and Femur Fractures
- Cardiac Arrest and Resuscitation
- Enhanced Recovery After Surgery
- Surgical site infection prevention
- COVID-19 Clinical Research Studies
- Nosocomial Infections in ICU
- Antibiotic Resistance in Bacteria
- Cardiac and Coronary Surgery Techniques
- Antibiotics Pharmacokinetics and Efficacy
- Anesthesia and Pain Management
- Hemodynamic Monitoring and Therapy
- Obstructive Sleep Apnea Research
- Eicosanoids and Hypertension Pharmacology
- Inflammatory Biomarkers in Disease Prognosis
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Vestibular and auditory disorders
- MicroRNA in disease regulation
Carol Davila University of Medicine and Pharmacy
2016-2025
Clinical Emergency Hospital Bucharest
2014-2024
University of Ferrara
2024
Iuliu Hațieganu University of Medicine and Pharmacy
2024
University Hospital Heidelberg
2024
Jagiellonian University
2024
Emergency University
2016-2024
Heinrich Heine University Düsseldorf
2024
Düsseldorf University Hospital
2024
Heidelberg University
2024
Hematological indices can predict disease severity, progression, and death in patients with coronavirus disease-19 (COVID-19).To study the predictive value of dynamic changes (first 48 h after ICU admission) following ratios: neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), monocyte-to-lymphocyte (MLR), systemic inflammation index (SII), derived (dNLR) for invasive mechanical ventilation (IMV) need critically ill COVID-19 patients.Observational, retrospective, multicentric...
Importance Staphylococcus aureus surgical site infections (SSIs) and bloodstream (BSIs) are important complications of procedures for which prevention remains suboptimal. Contemporary data on the incidence etiologic factors these needed to support development improved preventive strategies. Objectives To assess occurrence postoperative S SSIs BSIs quantify its association with patient-related contextual factors. Design, Setting, Participants This multicenter cohort study assessed patients at...
Background: The sequential organ failure assessment (SOFA) score has poor discriminative ability for death in severely or critically ill patients with Coronavirus disease 2019 (COVID-19) requiring intensive care unit (ICU) admission. Our aim was to create a new powered predict 28-day mortality. Methods: Retrospective, observational, bicentric cohort study including 425 COVID-19 pneumonia, acute respiratory and SOFA ≥ 2 ICU admission ≥72 h. Factors independent predictive value mortality were...
Background: Optimizing sedative techniques for drug-induced sleep endoscopy (DISE) enhances accuracy and reproducibility in tailoring treatment obstructive apnea (OSA). The Schnider Eleveld pharmacokinetic–pharmacodynamic (PK-PD) models, which predict propofol concentration effect-site compartment based on patient-specific parameters, were utilized to guide intravenous sedation this study. We compared the effectiveness of guided by novel general-purpose model versus using target-controlled...
Abstract Background The independent effects of extranasal-only carriage, carriage at multiple bodily sites, or the bacterial load colonizing Staphylococcus aureus (SA) on risk developing SA surgical site infections and postoperative bloodstream (SA SSI/BSIs) are unclear. We aimed to quantify these in this large prospective cohort study. Methods Surgical patients aged 18 years older were screened for nose, throat, perineum within 30 days before surgery. carriers noncarriers enrolled a study...
Patients with untreated anaemia or iron deficiency who undergo surgical procedures have an increased risk for mortality and morbidity.Patient Blood Management programmes address this issue worldwide try to improve patient outcomes through a complex set of measures targeting correction, minimisation bleeding improvement tolerance, in all phases perioperative care.The Patient Initiative Group is multidisciplinary team physicians from specialties including anaesthesiology, nephrology, surgery,...
Background. During the COVID-19 pandemic, resource allocation became a major problem in globally overwhelmed ICUs. The main goal of this study was to describe clinical characteristics very elderly patients (aged ≥ 80 years) with admitted Romanian objectives were evaluate and determine factors associated ICU mortality. Methods. We designed national, multicentric, observational platform prospective enrolment. This included aged years ICUs SARS-CoV-2 infection from March 2020 December 2021....
Background: Surgical stress response in colorectal surgery consists of a neurohormonal and an immunological influences oncological outcomes. The intensity surgical trauma mortality, morbidity, metastasis' occurrence neoplasia. Energy expenditure (EE) stands for the body's energy consumed to keep its homeostasis can be either calculated or measured by direct indirect calorimetry. Aim: present study attempted evaluate using EE measurement compare it postoperative cortisol dynamic. Methods: A...
Background and Objectives: Obstructive sleep apnea (OSA) is a prevalent sleep-disordered breathing pathology with significant clinical consequences, including increased cardiovascular risk cognitive decline. Continuous positive airway pressure (CPAP) the gold-standard treatment, but alternative strategies are sometimes needed for patients intolerant to CPAP. Drug-induced endoscopy (DISE) key diagnostic tool assessing upper obstruction in OSA subsequently tailoring surgical approach, sedation...
Acute respiratory distress syndrome (ARDS) can develop early in burn patients with inhalation injury the presence of cytokine storm and proinflammatory response be a supplemental factor for ARDS aggravation. We report case 41-years old male 25% total body surface area deep partial thickness burns to upper extremity grade II inhalational who developed severe ARDS, nosocomial pneumonia, septic shock. Veno-venous extracorporeal membrane oxygenation (VV ECMO) continuous renal replacement therapy...
Bacterial and viral sepsis induce alterations of all hematological parameters procalcitonin is used as a biomarker infection disease severity. Our aim was to study the patterns associated with pulmonary triggered by bacteria Severe Acute Respiratory Syndrome–Coronavirus–type-2 (SARS-CoV-2) identify discriminants between them. We performed retrospective, observational including 124 patients bacterial 138 sepsis. Discriminative ability types tested using receiver operating characteristic (ROC)...
Abstract Introduction : Simulation training offers an opportunity to educate anaesthesia and intensive care (AIC) residents safely. At present, it is not yet a mandatory part of residency curriculum. The aim the study was evaluate residents’ perception inclusion simulation-based in Romanian AIC program. Material methods: AICs from four centres completed twenty-question survey regarding their views on simulation during training. Residents were divided into junior, first three years, or senior...
Abstract Erythrocyte rheology is of interest in understanding microcirculation and oxygen delivery consumption alterations induced by sepsis septic shock. Several mechanisms are proposed: (i) direct or indirect RBC membrane alterations, (ii) abnormal intraerythrocytic homeostasis, (iii) RBCs interaction with other cells extracellular molecules, (iiii) increased reactive species production altered redox homeostasis. In this review, we describe part these what’s the impact hemorheological...