A5037862915- Mechanical Circulatory Support Devices
- Cardiac, Anesthesia and Surgical Outcomes
- Transplantation: Methods and Outcomes
- Hemodynamic Monitoring and Therapy
- Cardiac Arrest and Resuscitation
- Hip and Femur Fractures
- Heart Failure Treatment and Management
- Acute Kidney Injury Research
- Cardiac Structural Anomalies and Repair
- Trauma and Emergency Care Studies
- Organ Transplantation Techniques and Outcomes
- Intensive Care Unit Cognitive Disorders
- Central Venous Catheters and Hemodialysis
- Palliative Care and End-of-Life Issues
- Venous Thromboembolism Diagnosis and Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Magnesium in Health and Disease
- Anesthesia and Neurotoxicity Research
- Acute Ischemic Stroke Management
- Aortic aneurysm repair treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac Ischemia and Reperfusion
- Family and Patient Care in Intensive Care Units
- Anesthesia and Sedative Agents
- Advanced X-ray and CT Imaging
Heinrich Heine University Düsseldorf
2021-2025
Düsseldorf University Hospital
2021-2025
University of Ferrara
2024
Iuliu Hațieganu University of Medicine and Pharmacy
2024
University Hospital Heidelberg
2024
Jagiellonian University
2024
Emergency University
2024
Heidelberg University
2024
RWTH Aachen University
2018
Universitätsklinikum Aachen
2018
Importance Nearly 16 million surgical procedures are conducted in North America yearly, and postoperative cardiovascular events frequent. Guidelines suggest functional capacity or B-type natriuretic peptides (BNP) to guide perioperative management. Data comparing the performance of these approaches scarce. Objective To compare addition either N-terminal pro-BNP (NT-proBNP) self-reported clinical scores estimate risk major adverse cardiac (MACE). Design, Setting, Participants This cohort...
Summary Introduction Heart failure is a frequent comorbidity in patients undergoing non‐cardiac surgery and an acknowledged risk factor for postoperative mortality. The associations between stable chronic heart outcomes have not been explored extensively. aim of this study was to determine its peri‐operative management after major surgery. Methods This secondary analysis MET‐REPAIR, international prospective cohort including aged ≥ 45 y with increased cardiovascular risk. Main exposures were...
Primary graft dysfunction (PGD) is a feared complication after heart transplantation (HTX). HTX patients frequently receive veno-arterial extracorporeal membrane oxygenation (VA-ECMO) until recovery. Long-term mortality of weaned from VA-ECMO comparable with non-ECMO patients. However, impact on quality life unknown. This study investigated days alive and out hospital (DAOH) as patient-centred outcome in at 1 year surgery.
Abstract The number of patients waiting for heart transplantation (HTX) is increasing. Thus, identification outcome-relevant factors crucial. This study aimed to identify perioperative associated with days alive and out hospital (DAOH)—a patient-centered outcome quantify life impact—after HTX. retrospective cohort screened 187 who underwent HTX at university Duesseldorf, Germany from September 2010 December 2020. primary endpoint was DAOH 1 year. Risk mortality after were assessed in...
Implantation of left ventricular assist devices (LVADs) as a bridge to transplant or destination therapy is increasing. The selection suitable patients and outcome assessment belong the key challenges. Mortality has traditionally been focus research in this field, but literature on quality life very limited. This study aimed identify perioperative factors influencing patients' measured by days alive out hospital (DAOH) first year after LVAD implantation.
Abstract The use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is increasing, but mortality remains high. Early assessment prognosis challenging and valid markers are lacking. This study aimed to investigate Neutrophil–Lymphocyte Ratio (NLR), Platelet-Lymphocyte-Ratio (PLR) Procalcitonin (PCT) for early in patients undergoing VA-ECMO. retrospective single-center cohort included 344 consecutive ≥ 18 years who underwent VA-ECMO due cardiogenic shock. Main exposures were NLR,...
During resuscitation of patients with severe trauma, guidelines recommend permissive hypotension prior to surgical bleeding control. However, may be associated reduced organ perfusion and multiple dysfunction, e.g. myocardial injury. The association between injury in trauma is underexplored. We hypothesized that this population.This retrospective study included ≥ 18 years suffering from [defined as Injury Severity Score (ISS) 16] were treated the emergency department room 2016 2019. Primary...
Abstract OBJECTIVES In patients undergoing heart transplantation (HTX), preoperative liver impairment and consecutive hypoalbuminemia are associated with increased mortality. The role of early postoperative after HTX is unclear. This study investigated the association between 1-year mortality as well “days alive out hospital” (DAOH) HTX. METHODS retrospective cohort included who underwent at University Hospital Duesseldorf, Germany 2010 2022. main exposure was serum albumin concentration ICU...
Fibroblast growth factor 23 (FGF23) regulates phosphate metabolism by increasing renal excretion and decreasing 1.25-dihydroxyvitamin D synthesis. Reports about hypophosphatemia in patients with chronic obstructive pulmonary disease (COPD) suggest altered metabolism. Therefore, we hypothesized that disturbances phosphate-regulatory hormones such as FGF23 parathyroid hormone (PTH) are present COPD patients.We investigated 40 (63.5 ± 9.9 years, 27 male), each matched two age- sex-matched...
Severe trauma can lead to end organ damages of varying severity, including myocardial injury. In the non-cardiac surgery setting, there is extensive evidence that perioperative injury associated with increased morbidity and mortality. The impact on outcome after severe has not been investigated adequately yet. We hypothesized in-hospital mortality in patients trauma.This retrospective cohort study included ≥ 18 years [defined as severity score (ISS) 16] were admitted resuscitation room...
Background: The number of patients waiting for heart transplantation (HTX) is increasing. Optimizing the use all available donor hearts crucial. While mortality seems not to be affected by cardiopulmonary resuscitation (CPR), impact CPR on days alive and out hospital (DAOH) unclear. Methods: This retrospective study included adults who underwent HTX at University Hospital Duesseldorf, Germany from 2010–2020. Main exposure was donor-CPR. Secondary length CPR. primary endpoint DAOH one year....
Abstract Background Orthotopic heart transplantation (HTX) is the gold standard to treat end-stage failure. Numerous risk stratification tools have been developed in past years. However, their clinical utility limited by poor discriminative ability. High sensitivity troponin T (hsTnT) most specific biomarker detect myocardial cell injury. its prognostic relevance after HTX not fully elucidated. Thus, this study evaluated predictive value of postoperative hsTnT for 1-year survival and days...
Abstract Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) supports patients suffering from refractory cardiogenic shock. Thromboembolic complications (TeC) are common in VA-ECMO and associated with increased morbidity mortality. Valid markers to predict TeC lacking. The present study investigated the predictive value of baseline Fibrinogen–Albumin-Ratio (FAR) for in-hospital undergoing VA-ECMO. This retrospective cohort included who underwent therapy due shock at University...
Abstract Hemodynamic stabilization plays a crucial role in the treatment of patients suffering from severe trauma. Current guidelines recommend early administration tranexamic acid (TXA) for bleeding control. While less blood loss can result end-organ damage, including myocardial injury, TXA also exhibits prothrombotic effects with potentially adverse effects. The aim this study was to investigate association between and injury We conducted monocentric cohort severely injured ≥ 18 years...
Acute kidney injury (AKI), requiring renal replacement therapy (RRT). is a serious complication after orthotopic heart transplantation (HTX). In patients with preexisting impaired function, postoperative AKI unsurprising. However, even in preserved RRT frequent. Therefore, this study aimed to identify risk factors associated HTX sub-cohort. This retrospective cohort included ≥ 18 years of age function (defined as preoperative glomerular filtration rate 60 mL/min) who underwent between 2010...
Severe trauma potentially results in end-organ damage such as myocardial injury. Data suggest that injury is associated with increased mortality this cohort, but the association incidence of in-hospital major adverse cardiac events (MACE) remains undetermined. Retrospective cohort study including adult patients severe treated at University Hospital Duesseldorf between January 2016 and December 2019. The main exposure was presentation. Endpoints were MACE acute kidney (AKI) within 72 h....
IMPORTANCE: Cardiopulmonary resuscitation (CPR) is an exceptional physical situation and may lead to significant psychological, spiritual, social distress in patients their next of kin. Furthermore, clinicians might experience related a CPR event. Specialist palliative care (sPC) integration could address these aspects but not part routine care. OBJECTIVES: This study aimed explore perspectives on sPC during after CPR. A needs assessment for sPC, possible triggers indicating need,...
BACKGROUND Cardiac risk evaluation prior to noncardiac surgery is fundamental tailor peri-operative management patient's estimated risk. Data on the degree of adherence guidelines in patients at cardiovascular Europe and factors influencing are underexplored. OBJECTIVES The aim this analysis was describe [2014 European Society Cardiology (ESC)/European Anaesthesiology (ESA) guidelines] recommendations rest echocardiography [transthoracic (TTE)] stress imaging a large sample assess...