A5063620802- Muscle metabolism and nutrition
- Nutrition and Health in Aging
- Diet and metabolism studies
- Clinical Nutrition and Gastroenterology
- Exercise and Physiological Responses
- Sports Performance and Training
- Obesity, Physical Activity, Diet
- Dietary Effects on Health
- Agriculture Sustainability and Environmental Impact
- Muscle Physiology and Disorders
- Intensive Care Unit Cognitive Disorders
- Frailty in Older Adults
- Cardiovascular and exercise physiology
- Electrolyte and hormonal disorders
- Hip and Femur Fractures
- Nutritional Studies and Diet
- Abdominal Surgery and Complications
- Orthopaedic implants and arthroplasty
- Circadian rhythm and melatonin
- Nitric Oxide and Endothelin Effects
- Alcoholism and Thiamine Deficiency
- Adipose Tissue and Metabolism
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Acute Myocardial Infarction Research
- Neuroscience of respiration and sleep
Wageningen University & Research
2022-2025
Ziekenhuis Gelderse Vallei
2023-2025
The University of Adelaide
2021-2024
Australian Catholic University
2020-2024
Royal Adelaide Hospital
2021-2024
TiFN
2016-2024
Maastricht University Medical Centre
2011-2023
Center for Translational Molecular Medicine
2020
Maastricht University
2014-2019
Victoria School of Management
2019
Rationale: Dietary protein may attenuate the muscle atrophy experienced by patients in ICU, yet handling is poorly understood. Objectives: To quantify digestion and amino acid absorption fasting postprandial myofibrillar synthesis during critical illness. Methods: Fifteen mechanically ventilated adults (12 male; aged 50 ± 17 yr; body mass index, 27 5 kg⋅m−2) 10 healthy control subjects (6 54 23 4 received a primed intravenous L-[ring-2H5]-phenylalanine, L-[3,5-2H2]-tyrosine,...
Abstract Purpose Plant-derived proteins have received considerable attention as an alternative to animal-derived proteins. However, plant-derived are considered less anabolic properties when compared with The lower muscle protein synthesis rates following ingestion of plant- been attributed the essential amino acid content and/or their specific deficiencies. This study aimed compare post-prandial 30 g pea-derived milk-derived in healthy, young males. Methods In a randomized, double-blind,...
Abstract BACKGROUND Interpretation of serial high-sensitivity cardiac troponin (hs-cTn) measurements for the diagnosis acute myocardial infarction (AMI) assumes random fluctuation hs-cTn around an individual's homeostatic set point. The aim this study was to challenge diagnostic concept. METHODS Study 1 examined presence a diurnal rhythm by hourly blood sampling, day and night, in 24 individuals without recent history AMI. 2 assessed morning vs evening accuracy hs-cTnT hs-cTnI prospective...
The purpose of this study was to determine the impact ingesting 30 g casein protein with and without 2 free leucine before sleep on myofibrillar synthesis rates during postexercise overnight recovery. Thirty-six healthy young men performed a single bout resistance-type exercise in evening (1945) after full day dietary standardization. Thirty minutes (2330), subjects ingested intrinsically l-[1-13C]phenylalanine-labeled (PRO+leu, n = 12) or (PRO, leucine, noncaloric placebo (PLA, 12)....
Introduction We have previously shown that protein ingestion before sleep increases overnight muscle synthesis rates. Whether prior exercise further augments the synthetic response to presleep remains be established. Objective This study aimed assess whether resistance-type performed in evening ingestion. Methods Twenty-four healthy young men were randomly assigned ingest 30 g intrinsically L-[1-13C]-phenylalanine and L-[1-13C]-leucine-labeled casein going with (PRO + EX, n = 12) or without...
The rate of protein digestion and amino acid absorption determines the postprandial rise in circulating acids modulates muscle synthesis rates. We sought to compare digestion, kinetics, synthetic response following ingestion intact milk or an equivalent amount free acids. Twenty-four healthy, young participants (mean ± SD age: 22 3 y BMI 23 2 kg/m2; sex: 12 male female participants) received a primed continuous infusion l-[ring-2H5]-phenylalanine l-[ring-3,5–2H2]-tyrosine, after which they...
Plant-derived proteins are considered to have lesser anabolic properties when compared with animal-derived proteins. The attenuated rise in muscle protein synthesis rates following ingestion of plant-derived has been, at least partly, attributed deficiencies specific amino acids such as leucine, lysine, and/or methionine. Combining different could provide blends a more balanced acid profile. This study aimed compare postprandial the 30 g milk blend combining wheat, corn, and pea healthy...
Abstract Background Vitamin K is essential for numerous physiological processes, including coagulation, bone metabolism, tissue calcification, and antioxidant activity. Deficiency, prevalent in critically ill ICU patients, impacts coagulation increases the risk of bleeding other complications. This review aims to elucidate metabolism vitamin context critical illness identify a potential therapeutic approach. Methods In December 2023, scoping was conducted using PRISMA Extension Scoping...
Protein ingestion and cooling are strategies employed by athletes to improve postexercise recovery and, as such, facilitate muscle conditioning. However, whether affects postprandial protein handling subsequent synthesis rates during from exercise has not been assessed. We investigated the effect of on incorporation dietary protein-derived amino acids into acute (hourly) well prolonged (daily) myofibrillar resistance-type over 2 weeks. Cold-water immersion lowers capacity take up and/or...
Nitrate ([Formula: see text]) ingestion has been shown to have vasoactive and ergogenic effects that attributed increased nitric oxide (NO) production. Recent observations in rodents suggest skeletal muscle tissue serves as an endogenous [Formula: text] “reservoir.” The present study determined contents human a postabsorptive state following of sodium nitrate bolus (NaNO 3 ). Seventeen male, type 2 diabetes patients (age 72 ± 1 yr; body mass index 26.5 0.5 kg/m ; means SE) were randomized...
Abstract Plant-derived proteins are generally believed to possess lesser anabolic properties when compared with animal-derived proteins. This is, at least partly, attributed the lower leucine content of most plant-derived Corn protein has a that is highest among and it even exceeds levels observed in such as whey protein. Therefore, this study aimed compare muscle synthesis rates following ingestion 30 g corn blend plus milk In randomized, double blind, parallel-group design, 36 healthy...
Abstract Plant-derived proteins have been suggested to less anabolic properties when compared with animal-derived proteins. Whether blends of plant- and can compensate for their lesser potential has not assessed. The present study compares post-prandial muscle protein synthesis rates following the ingestion milk wheat or a blend plus in healthy, young males. In randomised, double-blind, parallel-group design, 36 males (23 ( sd 3) years) received primed continuous L-[ring- 13 C 6...
Abstract Plant-based proteins are considered to be less effective in their capacity stimulate muscle protein synthesis when compared with animal-based sources, likely due differences amino acid contents. We the postprandial synthetic response following ingestion of a lysine-enriched plant-based product an isonitrogenous amount chicken. Twenty-four men (age 24 ± 5 years; BMI 22·9 2·6 kg·m −2 ) participated this parallel, double-blind, randomised controlled trial and consumed 40 g as wheat...
Abstract Objective This study aimed to assess the impact of time‐restricted eating (TRE) on integrated skeletal muscle myofibrillar protein synthesis (MyoPS) rates in males with overweight/obesity. Methods A total 18 healthy (age 46 ± 5 years; BMI: 30 2 kg/m ) completed this exploratory, parallel, randomized dietary intervention after a 3‐day lead‐in diet. Participants then consumed an isoenergetic diet (protein: ~1.0 g/kg body mass per day) following either TRE (10:00 a.m. 6:00 p.m.) or...
We aimed to determine the impact of precursor pool dilution on assessment postprandial myofibrillar protein synthesis rates (MPS). A Holstein dairy cow was infused with large amounts L-[1-(13)C]phenylalanine and L-[1-(13)C]leucine, milk collected fractionated. The enrichment levels in casein were 38.7 9.3 mole percent excess, respectively. In a subsequent human experiment, 11 older men (age: 71 ± 1 y, body mass index: 26 0.1 kg·m(-2)) received primed constant infusion...
Short periods of bed rest lead to the loss muscle mass and quality. It has been speculated that dietary feeding pattern may have an impact upon protein synthesis rates and, therefore, modulate We subjected 20 healthy men (age: 25 ± 1 yr, body index: 23.8 0.8 kg/m2) wk strict with intermittent (4 meals/day) or continuous (24 h/day) enteral tube feeding. Participants consumed deuterium oxide for 7 days before throughout 7-day period. Prior immediately after rest, lean (dual energy X-ray...
Abstract Background Malnutrition is prevalent in hospitalized patients. To support muscle maintenance older and chronically ill patients, a protein intake of 1.2–1.5 g/kg/d has been recommended during hospitalization. We assessed daily levels distribution patients at risk for malnutrition Methods In this prospective, observational study, we measured actual food supplement consumption ( n = 102; age, 68 ± 14 years; hospital stay, [8–28] days) Food provided by meals, ONS, snacks the amount...