A5053479652- Dietary Effects on Health
- Diet and metabolism studies
- Muscle metabolism and nutrition
- Circadian rhythm and melatonin
- Cardiovascular and exercise physiology
- Adipose Tissue and Metabolism
- Sports Performance and Training
- Nutrition and Health in Aging
- Nutritional Studies and Diet
- Ovarian function and disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Glycogen Storage Diseases and Myoclonus
- MicroRNA in disease regulation
- Exercise and Physiological Responses
- Childhood Cancer Survivors' Quality of Life
- Health and Lifestyle Studies
- Menstrual Health and Disorders
- Obesity and Health Practices
- Reproductive Biology and Fertility
- Obesity, Physical Activity, Diet
- Heart Rate Variability and Autonomic Control
- Cancer survivorship and care
- High Altitude and Hypoxia
- Physical Activity and Health
- Genetic Neurodegenerative Diseases
Australian Catholic University
2016-2025
Collaborative Research Group
2016
University of Otago
2015-2016
RMIT University
2012-2014
We determined the effects of time-restricted feeding (TRF; 8 h/d) versus extended (EXF; 15 on 24-h and postprandial metabolism subjective opinions TRF in men with overweight/obesity. In a randomized crossover design, 11 sedentary males (age 38 ± 5 y; BMI: 32.2 2.0 kg/m2) completed two isoenergetic diet protocols for days, consuming meals at 1000, 1300 1700 h (TRF) or 0700, 1400 2100 (EXF). On Day 5, participants remained laboratory 24 h, blood samples were collected hourly (0700–2300 h) then...
Introduction The culture in many team sports involves consumption of large amounts alcohol after training/competition. effect such a practice on recovery processes underlying protein turnover human skeletal muscle are unknown. We determined the intake rates myofibrillar synthesis (MPS) following strenuous exercise with carbohydrate (CHO) or ingestion. Methods In randomized cross-over design, 8 physically active males completed three experimental trials comprising resistance (8×5 reps leg...
Time-restricted feeding (TRF) improves metabolism independent of dietary macronutrient composition or energy restriction. To elucidate mechanisms underpinning the effects short-term TRF, we investigated skeletal muscle and serum metabolic transcriptomic profiles from 11 men with overweight/obesity after TRF (8 h day-1) extended (EXF, 15 in a randomised cross-over design (trial registration: ACTRN12617000165381). Here show that core clock gene expression was similar both interventions....
Individuals with type 2 diabetes (T2D) require a long-term dietary strategy for blood glucose management and may benefit from time-restricted eating (TRE, where the duration between first last energy intake is restricted to 8–10 h/day). We aimed determine feasibility of TRE individuals T2D. Participants T2D (HbA1c >6.5 <9%, window >12 h/day) were recruited pre-post, non-randomised intervention consisting 2-week Habitual period establish baseline intake, followed by 4-weeks during...
Abstract Aims/hypothesis We determined whether the time of day exercise training (morning vs evening) would modulate effects consumption a high-fat diet (HFD) on glycaemic control, whole-body health markers and serum metabolomics. Methods In this three-armed parallel-group randomised trial undertaken at university in Melbourne, Australia, overweight/obese men consumed an HFD (65% energy from fat) for 11 consecutive days. Participants were recruited via social media community advertisements....
Background Interactions between diet, physical activity and genetic predisposition contribute to variable body mass changes observed in response weight loss interventions. Circulating microRNAs (c-miRNAs) may act as 'biomarkers' that are associated with the rate of change loss, and/or play a role regulating biological variation, energy restriction. Objective To quantify targeted c-miRNAs putative roles metabolism exercise adaptations following 16 wk diet intervention individuals large (high...
Advances in the field of metabolomics and concomitant development bioinformatics tools constitute a promising avenue towards precision medicine personalized profiling for numerous disease states. Studies animal models have strengthened this concept, but application human subjects is scarce. Utilizing high-throughput metabolomics, we analyzed metabolome levels serum skeletal muscle morning evening response to divergent nutritional challenges order identify unique signatures present muscle. We...
High-fat, low-carbohydrate (CHO) diets increase whole-body rates of fat oxidation and down-regulate CHO metabolism. We measured substrate utilization skeletal muscle mitochondrial respiration to determine whether these adaptations are driven by high or low availability. In a randomized crossover design, 8 male cyclists consumed 5 d high-CHO diet [>70% energy intake (EI)], followed either an isoenergetic high-fat (HFAT; >65% EI) high-protein (HPRO; with clamped at <20% EI. During the...
Cachexia is a prevalent muscle wasting syndrome among people with advanced cancer that profoundly impacts patient quality of life (QoL) and physical function. Exercise can improve QoL, function, overall health in may be an important addition to treatment approaches for cachexia. Greater understanding patients' perception exercise help elucidate the feasibility implementing interventions cachexia facilitate design patient-centered interventions. We aimed describe patients cachexia, capture...
When ingested alone, beetroot juice and sodium bicarbonate are ergogenic for high-intensity exercise performance. This study sought to determine the independent combined effects of these supplements. Eight endurance trained (VO 2 max 65 mL·kg·min -1 ) male cyclists completed four × 4-km time trials (TT) in a doubleblind Latin square design supplementing with crystals (BC) 3 days (15 g·day + 15 g 1 h before TT, containing 300 mg nitrate per g), (Bi 0.3 g·kg body mass [BM] 5 doses every min...
Abstract Objective This study aimed to assess the impact of time‐restricted eating (TRE) on integrated skeletal muscle myofibrillar protein synthesis (MyoPS) rates in males with overweight/obesity. Methods A total 18 healthy (age 46 ± 5 years; BMI: 30 2 kg/m ) completed this exploratory, parallel, randomized dietary intervention after a 3‐day lead‐in diet. Participants then consumed an isoenergetic diet (protein: ~1.0 g/kg body mass per day) following either TRE (10:00 a.m. 6:00 p.m.) or...
In individuals with McArdle disease (IWMD), the ingestion of carbohydrates before exercise has previously been shown in laboratory studies to significantly decrease exercising symptoms condition and increase tolerance during early stages exercise. As a result, carbohydrate pre-exercise is currently included management guidelines, often advised by medical professionals treating condition. The aim current study was determine whether positive lab-based results for are being effectively...
AimsTime-restricted eating (TRE) is a chrono-nutrition strategy where the daily 'eating window' reduced to 8–10 h. We investigated acute (14-h) effects of TRE, with and without post-meal exercise, on blood glucose insulin concentrations in people type 2 diabetes mellitus.MethodsFourteen participants (5F, 9 M; HbA1c: 7.6 ± 1.0 %) completed four conditions this randomised crossover study: CON (eating window, 0800–2000 h), exercise (CON + Ex; h 15 min walking at 60 %VO2peak, 45 post-meal), TRE...
Abstract Aims Blood pressure (BP) responses to exercise are frequently measured, with the concern that greater increases a marker of disease. We sought characterize normal BP response in healthy adults and its relationships age, sex, fitness. Methods results Five hundred eighty-nine participants [median age 46 (interquartile range 24–56) years, 81% male] underwent cardiopulmonary testing repeated, automated measures. An exaggerated maximal systolic (SBPmax) was defined from current...
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally. In women with polycystic ovary syndrome (PCOS), several miRNAs differentially expressed compared to without PCOS, suggesting may underpin the pathophysiology of this condition. Exercise training modulates miRNA abundance and is recommended as a primary lifestyle intervention for PCOS. Accordingly, we measured eight circulating selected priori along from gluteal abdominal adipose tissue (AT) in...