A5029656513- Ovarian function and disorders
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Reproductive Biology and Fertility
- Birth, Development, and Health
- Ovarian cancer diagnosis and treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive System and Pregnancy
- Pregnancy and Medication Impact
- Reproductive Health and Technologies
- Hormonal and reproductive studies
- Ectopic Pregnancy Diagnosis and Management
- Maternal and fetal healthcare
- Maternal Mental Health During Pregnancy and Postpartum
- Growth Hormone and Insulin-like Growth Factors
- Lipid metabolism and disorders
- Breastfeeding Practices and Influences
- Cancer Risks and Factors
- Maternal and Perinatal Health Interventions
- Folate and B Vitamins Research
- Cardiovascular Issues in Pregnancy
- Sexual Differentiation and Disorders
- Endometriosis Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Hormonal Regulation and Hypertension
Norwegian University of Science and Technology
2016-2025
St Olav's University Hospital
2015-2024
RELX Group (United States)
2019
Metropolitan University
2018
University of California, San Francisco
2017
Park Terrace Care Center
2017
KITH (Norway)
2016
Norwegian Womens Public Health Association
2014
Women's & Children's Health Research Institute
2011
University Hospital of North Norway
2004
What is the recommended assessment and management of women with polycystic ovary syndrome (PCOS), based on best available evidence, clinical expertise consumer preference?International evidence-based guidelines, including 166 recommendations practice points, addressed prioritized questions to promote consistent, care improve experience health outcomes PCOS.Previous guidelines either lacked rigorous processes, did not engage international multidisciplinary perspectives, or were outdated....
Metformin is widely prescribed to pregnant women with polycystic ovary syndrome (PCOS) in an attempt reduce pregnancy complications. not approved for this indication, and evidence practice lacking.Our objective was test the hypothesis that metformin, from first trimester delivery, reduces complications PCOS.We conducted a randomized, placebo-controlled, double-blind, multicenter study at 11 secondary care centers.The participants were 257 PCOS, of pregnancy, aged 18-42 yr.We randomly...
Metformin is used in pregnancy women with gestational diabetes mellitus, polycystic ovary syndrome (PCOS), and obesity. passes the placenta. To explore effects of metformin use PCOS pregnancies on offspring growth to 4 years age. Follow-up study two randomized, double-blind, placebo-controlled trials. Secondary care centers. Eleven public hospitals Norway. One hundred eighty-two children mothers who participated randomized controlled 1700 or 2000 mg/d placebo from first trimester delivery...
What is the recommended assessment and management of those with polycystic ovary syndrome (PCOS), based on best available evidence, clinical expertise, consumer preference?
STUDY QUESTIONWhat is the recommended assessment and management of those with polycystic ovary syndrome (PCOS), based on best available evidence, clinical expertise, consumer preference?SUMMARY ANSWERInternational evidence-based guidelines address prioritized questions outcomes include 254 recommendations practice points, to promote consistent, care improve experience health in PCOS.WHAT IS KNOWN ALREADYThe 2018 International PCOS Guideline was independently evaluated as high quality...
What is the recommended assessment and management of those with polycystic ovary syndrome (PCOS), based on best available evidence, clinical expertise, consumer preference?
BACKGROUND: Investigation of a possible effect metformin on androgen levels in pregnant women with polycystic ovary syndrome (PCOS). METHODS: A prospective, randomized, double-blind, placebo-controlled pilot study was conducted. Forty PCOS received diet and lifestyle counselling were randomized to either 850 mg twice daily or placebo. Primary outcome measures changes serum dehydroepiandrosterone sulphate, androstenedione, testosterone, sex hormone-binding globulin, free testosterone index....
Can anti-Müllerian hormone (AMH) level replace the morphologic description in diagnosis of polycystic ovary syndrome (PCOS) and what is relationship between AMH different diagnostic criteria PCOS? may be a good substitute for ovarian morphology (PCOM) diagnosing PCOS. has been suggested as an alternative to antral follicle count (AFC) Cut-off values studied so far show acceptable specificity but rather poor sensitivity, leaving up one-third PCOS women undiagnosed. We used data from...
What is the recommended assessment and management of infertile women with polycystic ovary syndrome (PCOS), based on best available evidence, clinical expertize consumer preference?International evidence-based guidelines, including 44 recommendations practice points, addressed prioritized questions to promote consistent, care improve experience health outcomes PCOS.Previous guidelines PCOS lacked rigorous processes, failed engage multidisciplinary perspectives or were outdated. The are...
Pregnancy implies delicate immunological balance between two individuals, with constant changes and adaptions in response to maternal capacity fetal demands. We performed cytokine profiling of 1149 longitudinal serum samples from 707 pregnant women map first trimester term beyond. The levels 22 cytokines C-reactive protein (CRP) followed diverse but characteristic trajectories throughout pregnancy, consistent staged adaptions. Eotaxin showed a particularly robust decrease pregnancy. A strong...
Abstract Screening for polycystic ovary syndrome (PCOS) in antenatal care is inadequate, largely owing to the lack of clarity around whether PCOS an independent risk factor pregnancy complications. This systematic review and meta-analysis include 104 studies 106,690 pregnancies women with without from inception until 13th July 2022. We report that are younger have higher body mass index (BMI) conception greater gestational weight gain. The odds miscarriage, diabetes mellitus, hypertension,...
Women with polycystic ovary syndrome (PCOS) have increased androgen secretion throughout fertile life; however, the data on effect of menopause hyperandrogenemia in these women are scarce. Nevertheless, large comprehensive comparative studies age-related levels PCOS lacking. The objective study was to investigate age serum and determine cutoff values for androgens SHBG associated a diagnosis. This case-control study. conducted five university sites Nordic countries. In all, 681 230 referent...
To investigate the possible long-term effects of metformin exposure on growth and development offspring born to mothers with polycystic ovary syndrome (PCOS). The drug passes through placenta can potentially influence fetus.This is a follow-up study randomized, controlled trial PCOS women, randomized or placebo in pregnancy. Out 37 children aged 7-9 years, 25 agreed participate. Primary outcome measures were growth, body composition metabolic parameters.There no differences height, weight...
The impact of metformin medication in pregnant women with polycystic ovary syndrome on weight gain during pregnancy and after delivery the growth offspring are essentially unexplored.This is a follow-up study randomized controlled trial (The Metformin treatment PCOS study), conducted 11 secondary care centers. Women were to (2000 mg daily) or placebo from first trimester delivery. Questionnaires sent 256 participants 1 year postpartum. Maternal development anthropometry at birth postpartum...
Does polycystic ovary syndrome (PCOS) in women without pregnancy complications affect placental signal transducer and activator of transcription 3 (STAT3) mechanistic target rapamycin (mTOR) signaling?Placental STAT3 signaling is activated but mTOR unaffected PCOS.Women with PCOS have increased risk poor outcomes (e.g. restricted or accelerated fetal growth), indicating dysfunction. Placental pathways regulate function indirectly growth.In a case-control study, tissue maternal blood were...
Current data suggest that excessive androgen exposure can lead to the development of polycystic ovaries and ovary syndrome (PCOS). Anti-Müllerian hormone (AMH) levels reflect number small antral follicles in are elevated PCOS. We hypothesized protracted reduction circulating androgens and/or insulin resistance would reduce AMH concentrations women with A prospective, randomized, double-blind 26 week long study was undertaken 50 They all received diet lifestyle counselling, metformin 850 mg...
Objective To date, little is known about differences in the knowledge, diagnosis making and treatment strategies of health care providers regarding polycystic ovary syndrome (PCOS) across different disciplines countries with similar systems. inform guideline translation, we aimed to study physician reported awareness, management PCOS explore between medical Nordic Estonia. Methods This cross-sectional survey was conducted among 382 endocrinologists obstetrician-gynaecologists Estonia...