A5014919873- Metabolomics and Mass Spectrometry Studies
- Cancer, Lipids, and Metabolism
- vaccines and immunoinformatics approaches
- Reproductive System and Pregnancy
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Mental Health Research Topics
- Cancer, Hypoxia, and Metabolism
- Bioinformatics and Genomic Networks
- Ovarian function and disorders
- Escherichia coli research studies
- Simulation-Based Education in Healthcare
- Clostridium difficile and Clostridium perfringens research
- Molecular Biology Techniques and Applications
- Advanced Chemical Sensor Technologies
- Ginseng Biological Effects and Applications
- Clinical Reasoning and Diagnostic Skills
- Lipoproteins and Cardiovascular Health
- Intraoperative Neuromonitoring and Anesthetic Effects
- Endometriosis Research and Treatment
- Statistical Methods and Inference
- Pregnancy and Medication Impact
- Innovations in Medical Education
- Metabolism, Diabetes, and Cancer
- Nutrition and Health in Aging
Norwegian University of Science and Technology
2017-2023
Nasjonalforeningen for Folkehelsen
2006
Norwegian Institute of Public Health
2006
Pregnancy implies delicate immunological balance between two individuals, with constant changes and adaptions in response to maternal capacity fetal demands. We performed cytokine profiling of 1149 longitudinal serum samples from 707 pregnant women map first trimester term beyond. The levels 22 cytokines C-reactive protein (CRP) followed diverse but characteristic trajectories throughout pregnancy, consistent staged adaptions. Eotaxin showed a particularly robust decrease pregnancy. A strong...
The emergence of SARS-CoV-2 variants concern (VOC) is driven by mutations that mediate escape from neutralizing antibodies. There also evidence can cause loss T cell epitopes. However, studies on viral immunity have been hampered uncertain estimates epitope prevalence. Here, we map and quantify CD8 responses to SARS-CoV-2-specific minimal epitopes in blood drawn April June 2020 83 COVID-19 convalescents. Among 37 HLA ligands eluted five prevalent alleles an additional 86 predicted binders,...
To explore how family caregivers experience involvement in palliative care.A qualitative design with a narrative approach was used.Purposive sampling and interviews were conducted. Eleven bereaved for patients cancer receiving care interviewed Mid-Norway between November 2016-May 2017.We identified four themes related to caregivers' experiences of the early, middle, terminal bereavement phases care: (a) limited early phase; (b) emphasis on patient-centred middle (c) lack preparation dying...
Longitudinal intervention studies with repeated measurements over time are an important type of experimental design in biomedical research. Due to the advent "omics"-sciences (genomics, transcriptomics, proteomics, metabolomics), longitudinal generate increasingly multivariate outcome data. Analysis such data must take both structure and nature into account. The ASCA+-framework combines general linear models principal component analysis can be used separate visualize effect different...
This review describes the current status of NMR-based metabolomics biofluids with respect to cancer risk assessment, detection, disease characterization, prognosis, and treatment monitoring. While metabolism cells is altered compared that non-proliferating cells, metabolome blood urine reflects entire organism. We conclude many studies show impressive associations between biofluid progression, but translation clinical practice currently hindered by lack validation, difficulties in biological...
The increasing availability of multivariate data within biomedical research calls for appropriate statistical methods that can describe and model complex relationships between variables. extended ANOVA simultaneous component analysis (ASCA+) framework combines general linear models principal (PCA) to decompose visualize the separate effects experimental factors. It has recently been demonstrated how mixed be included in analyze from longitudinal designs with repeated measurements (RM-ASCA+)....
Abstract Context Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with low-grade inflammation and increased incidence of pregnancy complications, but its influence on the maternal immune system in unknown. Longitudinal serum cytokine profiling sensitive measure complex immunological dynamics pregnancy. Objective This work aimed to determine cytokines throughout women PCOS compare it without PCOS. Methods A post hoc analysis was conducted longitudinal samples from 2...
Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with low-grade systemic inflammation and increased risk of pregnancy complications. Metformin treatment reduces the late miscarriage preterm birth in pregnant women PCOS. Whether protective effect metformin involves immunological changes has not been determined.To investigate on maternal status PCOS.A post-hoc analysis was performed two randomized controlled trials, PregMet PregMet2, including longitudinal serum...
Breast cancer treatment has metabolic side effects, potentially affecting risk of cardiovascular disease (CVD) and recurrence. We aimed to compare alterations in serum metabolites lipoproteins during between recipients non-recipients chemotherapy, describe metabolite profiles associated with treatment-related weight gain. This pilot study includes 60 stage I/II breast patients who underwent surgery were treated according national guidelines. Serum sampled pre-surgery after 6 12 months was...
The multimodal treatment of breast cancer may induce long term effects on the metabolic profile and increase risk future cardiovascular disease. In this study, we characterized longitudinal changes in serum lipoprotein subfractions metabolites after treatment, aiming to determine long-term effect different modalities. Further, investigated prognostic value treatment-induced cancer-specific overall 10-year survival. samples from patients (n = 250) were collected repeatedly before...
Background: Metabolomic characterization of tumours can potentially improve prediction cancer prognosis and treatment response. Here, we describe efforts to validate previous metabolomic findings using a historical cohort breast patients discuss challenges with older biobanks collected non-standardized sampling procedures. Methods: In total, 100 primary samples were analysed by high-resolution magic angle spinning magnetic resonance spectroscopy (HR MAS MRS) subsequently examined histology....
On 20 and 21 February 2006, six cases of diarrhoea-associated haemolytic uraemic syndrome (HUS) were reported to Nasjonalt
Abstract Longitudinal intervention studies with repeated measurements over time are an important type of experimental design in biomedical research. Due to the advent “omics”-sciences (genomics, transcriptomics, proteomics, metabolomics), longitudinal generate increasingly multivariate outcome data. Analysis such data must take both structure and nature into account. The ASCA+-framework combines general linear models principal component analysis, can be used separate visualize effect...
Abstract T-cell epitopes with broad population coverage may form the basis for a new generation of SARS-CoV-2 vaccines. However, published studies on immunoprevalence are limited by small test cohorts, low frequencies antigen-specific cells and lack data correlating eluted HLA ligands responsiveness. As protective role pre-existing cross-reactivity to homologous peptides is unclear, we aimed identify SARS-CoV-2-specific minimal recognized CD8 T-cells among 48 from prevalent alleles, an...
e23095 Background: Breast tumors are highly heterogeneous due to subpopulations of cancer cells that differ in genetic and phenotypic characteristics. Tumor heterogeneity has been associated with treatment resistance relapse. Therefore, it can be questioned how representative one biopsy is for the whole tumor. cannot solely attributed differences, as epigenetics interaction tumor microenvironment also contribute. In this study we have examined intra-tumor by measuring metabolite expression...
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e23043 Serum metabolism during breast cancer treatment Background: Breast may include surgery, systemic therapy and radiation, often involving side-effects. Many patients experience weight gain treatment, which is associated with decreased survival rates 1 . The purpose of this study was to describe serum metabolic alterations in undergoing relate these treatment. Methods: This pilot includes 60 patients, aged 35-75 years, histologically verified stage I/II disease. All underwent tumor were...
Abstract Background: Adjuvant breast cancer treatment may cause metabolic perturbations, such as dyslipidaemia, potentially exacerbating risk of cardiometabolic disease well recurrence. Physical exercise have beneficial effects, but it’s effect on serum lipoprotein- and metabolite profiles during adjuvant including chemotherapy is not yet established. Methods: The women participating in this pilot study Energy Balance Breast Cancer Aspects (EBBA)-II, were aged 38-69 years diagnosed with...