A5011117707- Kidney Stones and Urolithiasis Treatments
- Thermoregulation and physiological responses
- Electrolyte and hormonal disorders
- Renal Transplantation Outcomes and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urinary Bladder and Prostate Research
- Chronic Kidney Disease and Diabetes
- Body Composition Measurement Techniques
- Acute Kidney Injury Research
- Ion Transport and Channel Regulation
- Pharmacological Effects and Toxicity Studies
- Renal and Vascular Pathologies
- Organ Transplantation Techniques and Outcomes
- Urinary Tract Infections Management
- Dialysis and Renal Disease Management
- Pediatric Urology and Nephrology Studies
- Pelvic floor disorders treatments
- Nitric Oxide and Endothelin Effects
- Organ Donation and Transplantation
- Blood Pressure and Hypertension Studies
- Liver Disease and Transplantation
- Renal function and acid-base balance
- Pain Mechanisms and Treatments
- Apelin-related biomedical research
- Parathyroid Disorders and Treatments
Université de Toulouse
2007-2023
Inserm
2011-2023
University of Zurich
2023
Institut des Maladies Génétiques Imagine
2023
Collaborative Group (United States)
2023
Hôpital Rangueil
2013-2022
Centre Hospitalier Universitaire de Toulouse
2005-2022
Université Toulouse III - Paul Sabatier
2010-2021
Institut des Maladies Métaboliques et Cardiovasculaires
2012-2021
American Urological Association
2015
The results presented herein demonstrate that apelin is expressed and secreted by both human mouse adipocytes. Apelin mRNA levels in isolated adipocytes are close to other cell types present white adipose tissue or organs known express such as kidney, heart, a lesser extent brown tissue. expression increased during adipocyte differentiation stage. A comparison of four different models obesity mice showed large increase fat cells plasma all the hyperinsulinemia-associated obesities clearly...
Increased hydration is often recommended as a preventive measure for women with recurrent cystitis, but supportive data are sparse.To assess the efficacy of increased daily water intake on frequency cystitis in premenopausal women.Randomized, open-label, controlled, 12-month trial at clinical research center (years 2013-2016). Among 163 healthy (≥3 episodes past year) drinking less than 1.5 L fluid assessed eligibility, 23 were excluded and 140 assigned to or control group. Assessments...
Our group has recently demonstrated (Gesta, S., Simon, M., Rey, A., Sibrac, D., Girard, Lafontan, Valet, P., and Saulnier-Blache, J. S. (2002) Lipid Res. 43, 904-910) the presence, in adipocyte conditioned-medium, of a soluble lysophospholipase d-activity (LPLDact) involved synthesis bioactive phospholipid lysophosphatidic acid (LPA). In present report, LPLDact was purified from 3T3F442A adipocyte-conditioned medium identified as type II ecto-nucleotide pyrophosphatase phosphodiesterase,...
Gitelman's syndrome (GS) is a rare, autosomal recessive, salt-losing tubulopathy caused by mutations in the SLC12A3 gene, which encodes thiazide-sensitive NaCl cotransporter (NCC). Because 18 to 40% of suspected GS patients carry only one mutant allele, large genomic rearrangements may account for unidentified mutations. Here, we directly sequenced DNA from cohort 448 unrelated having GS. We found 172 distinct mutations, 100 were unreported previously. In 315 (70%), identified two mutations;...
Little is known about the impact of habitual fluid intake on physiology. Specifically, biomarkers hydration status and body water regulation have not been adequately explored in adults who consume different volumes everyday conditions, without prolonged exercise or environmental exposure. The purpose present study was to compare with habitually intakes respect implicated assessment status, total risk kidney pathologies. In cross-sectional study, seventy-one (thirty-two men, thirty-nine...
While associations exist between water, hydration, and disease risk, research quantifying the dose-response effect of water on health is limited. Thus, intake necessary to maintain optimal hydration from a physiological standpoint remains unclear. The aim this analysis was derive 24 h urine osmolality (U Osm ) threshold that would provide an index “optimal hydration,” sufficient compensate losses also be biologically significant relative risk disease. Ninety-five adults (31.5 ± 4.3 years,...
In sedentary adults, hydration is mostly influenced by total fluid intake and not sweat losses; moreover, low daily associated with adverse health outcomes. This study aimed to model the relation between urinary biomarkers. During 4 consecutive weekdays, 82 adults (age, 31.6±4.3 years; body mass index, 23.2±2.7 kg/m2; 52% female) recorded food consumed, collected one first morning urine (FMU) void three 24-h (24hU) samples. The strength of linear association biomarkers volume was evaluated...
Mutations in the ATP6V1B1 and ATP6V0A4 genes, encoding subunits B1 4 of apical H(+) ATPase, cause recessive forms distal renal tubular acidosis (dRTA). ATP6V1B mutations have been associated with early sensorineural hearing loss (SNHL), whereas are classically either late-onset SNHL or normal hearing. The phenotype genotype 39 new kindreds dRTA, 18 whom were consanguineous, assessed. Novel known loss-of-function identified 31 kindreds. Fourteen five recurrent gene 21 families. For gene, two...
Patients with Gitelman syndrome (GS), an inherited salt-losing tubulopathy, are usually treated potassium-sparing diuretics or nonsteroidal anti-inflammatory drugs and oral potassium magnesium supplementations. However, evidence supporting these treatment options is limited to case series studies. We designed open-label, randomized, crossover study blind end point evaluation compare the efficacy safety of 6-week treatments one time daily 75 mg slow-release indomethacin, 150 eplerenone, 20...
Metabolic syndrome can induce chronic kidney disease in humans. Genetically engineered mice on a C57BL/6 background are highly used for mechanistic studies. Although it has been shown that metabolic induces cardiovascular lesions mice, depth renal phenotyping never performed. Therefore this study we characterized function and injury with long-term induced by high fat fructose diet (HFFD). received an 8 months HFFD enriched (45% energy from fat) drinking water (30%). Body weight, food/water...
Abstract. Diabetic glomerulosclerosis is characterized by the accumulation of extracellular matrix (ECM) in mesangium. Estrogens seem to retard whereas estrogen deficiency seems accelerate progressive glomerulosclerosis. Thus, mesangial cells (MC) may be a target for estrogens. Estrogen action mediated via receptor (ER) subtypes ERα and ERβ. Both ER were expressed human mouse MC. Using an estrogen-responsive reporter construct transfection assays, it also was demonstrated that nuclear...
Study Type – Therapy (cost‐effectiveness meeting) Level of Evidence 2b What's known on the subject? and What does study add? One major problems with nephrolithiasis is high rate recurrence, which can effect up to 50% patients over a 5‐year period. Patients recurrent stones are recommended increase fluid intake based prospective studies that show reduction in recurrence rates who volume water. Strategies reduce stone formers quite effective >50% risk increased alone. Unfortunately, despite...
We evaluated the economic impact of preventing recurrent stones using a strategy increased water intake and determined compliance on cost-effectiveness for French health care system.A Markov model was constructed to compare costs outcomes kidney stone formers with less than 2 L vs or more daily fluid intake. Model assumptions included an annual prevalence 120,000 episodes in France, 14.4% risk recurrence 55% reduction subjects adequate Costs were based resource use as estimated by panel...
Abstract Introduction The aim of this study, performed in an intensive care unit (ICU) population with a normal serum creatinine, was to estimate urinary creatinine clearance (CL CR ) polytrauma patients (PT) through comparison non trauma (NPT). Methods This retrospective, observational study medical and surgical ICU university hospital. A total 284 were consecutively included. Two different groups studied: PT ( n = 144) NPT 140). Within the second week after admission ICU, renal function...
Significance Statement About 1% of the population is heterozygous for loss-of-function variants in SLC12A3 , which encodes thiazide-sensitive sodium-chloride cotransporter. Biallelic mutations are responsible Gitelman syndrome, a salt-losing tubulopathy. In cross-sectional study 81 carriers, 82 healthy noncarriers, and 79 patients with syndrome similar age, body mass index, sex ratio, authors assessed findings from home BP monitoring, oral glucose tolerance testing, assays plasma urine...
Gain-of-function mutations in with no lysine (K) 1 (WNK1) and WNK4 genes are responsible for familial hyperkalemic hypertension (FHHt), a rare, inherited disorder characterized by arterial hyperkalemia metabolic acidosis. More recently, FHHt-causing the Kelch-like 3–Cullin 3 (KLHL3-CUL3) E3 ubiquitin ligase complex have shed light on importance of WNK's cellular degradation renal ion transport. Using full exome sequencing 4-generation family then targeted other suspected cases, we identified...
Murine unilateral ureteral obstruction (UUO), a major model of progressive kidney disease, causes loss proximal tubular mass and formation atubular glomeruli. Adult C57BL/6 mice underwent sham operation or reversible UUO under anesthesia. In group 1, kidneys were harvested after 7 days. 2, the was released days, physiological study both performed 30 days later. Renal blood flow (RBF), glomerular filtration rate (GFR), urine protein, albumin excretion measured ligation either left right...
* In burn patients it has been shown ([2]), that there is a correlation between the creatinine clearance (CL(CR)) and of inulin. The CL(CR) never studied in who have normal serum creatinine. Robert, Kirkpatrick sMDRD formulae evaluated patients.
The standard dosage recommendations for beta-lactam antibiotics can result in very low drug levels intensive care (IC) patients and burn the absence of renal dysfunction. We studied pharmacokinetic parameters serum concentrations ceftazidime (CF) cefepime (CE) analyzed modifications according to clinical biological particular age creatinine clearance.Two studies were carried out with daily doses 1 g x 6 CF (n = 17) 2 3 CE 13). Creatinine clearance (CL(CR)) was both estimated measured. Blood...
Sparse data are available on renal consequences of hemorrhagic shock in mice. This study aimed to extend the current knowledge functional and morphologic impact mice determine its ability stand as an accurate model acute kidney injury.In vivo study.University research unit.C57/Bl6 mice.A controlled was adapted mice.Renal functions morphology were followed up from 3 hrs 21 days after shock. When prolonged 2 hrs, hypotension (35 mm Hg mean arterial blood pressure) induced by temporary removal...