A5063104348- Estrogen and related hormone effects
- Cholesterol and Lipid Metabolism
- Cancer, Lipids, and Metabolism
- Forensic and Genetic Research
- Steroid Chemistry and Biochemistry
- Forensic Anthropology and Bioarchaeology Studies
- Tuberculosis Research and Epidemiology
- Advancements in Transdermal Drug Delivery
- Advanced Polymer Synthesis and Characterization
- Surfactants and Colloidal Systems
- Chemical Synthesis and Analysis
- Animal Disease Management and Epidemiology
- Mycobacterium research and diagnosis
- Pancreatic function and diabetes
- Advanced Electron Microscopy Techniques and Applications
- biodegradable polymer synthesis and properties
- Supramolecular Self-Assembly in Materials
- Lipid metabolism and biosynthesis
- Hydrogels: synthesis, properties, applications
- Virology and Viral Diseases
- Diet and metabolism studies
- Mitochondrial Function and Pathology
- Polymer Surface Interaction Studies
- Skin Protection and Aging
- Free Radicals and Antioxidants
Université Toulouse III - Paul Sabatier
2012-2025
Université de Toulouse
2014-2023
Hôpital Rangueil
2007-2023
Inserm
2004-2022
Centre National de la Recherche Scientifique
2007-2022
Centre de Recherche en Cancérologie de Toulouse
2022
La Ligue Contre le Cancer
2022
Softmat - Chimie des colloïdes, polymères & assemblages complexes
2007-2015
Institut Claudius Regaud
2008-2010
DuPont (United States)
2004
Sunscreens, whose main function is to protect the skin against harmful effects of solar irradiation, should remain at surface or impregnate first layers stratum corneum only and not penetrate into underlying living tissue. The goal this work was assess penetration titanium dioxide (TiO<sub>2</sub>) methylene bis-benzotriazoyl tetramethylbutylphenol (MBBT), included in a broad-spectrum sunscreen formulation, human vivo, using tape stripping method, vitro, compartmental approach....
The use of synthetic drugs against gastrointestinal nematodes ruminants has led to a situation where resistance anthelmintics is widespread, and there an urgent need for alternative solutions parasite control. One promising approach polyphenol-rich bioactive plants in animal feeds as natural anthelmintics. In the present work, vitro activity series 33 hydrolyzable tannins (HTs) their hydrolysis product, gallic acid, egg hatching motility L1 L2 stage Haemonchus contortus larvae was studied....
Dendrogenin A (DDA) is a newly discovered cholesterol metabolite with tumor suppressor properties. Here, we explored its efficacy and mechanism of cell death in melanoma acute myeloid leukemia (AML). We found that DDA induced lethal autophagy vitro vivo, including primary AML patient samples, independently Braf status or molecular cytogenetic classifications. partial agonist on liver-X-receptor (LXR) increasing Nur77, Nor1, LC3 expression leading to autolysosome formation. Moreover,...
Adherent-invasive Escherichia coli (AIEC) have been shown to be highly associated with ileal Crohn's disease (CD). AIEC survive within infected macrophages, residing the phagolysosomal compartment where they take advantage of low pH replicate extensively. We investigated whether, like tuberculous bacillus which also persists LF82 induces formation granulomas, are a common histopathological feature CD. For this purpose, we taken an in vitro model human granulomas that recently developed,...
Nanotherapy using targeted magnetic nanoparticles grafted with peptidic ligands of receptors overexpressed in cancers is a promising therapeutic strategy. However, nanoconjugation peptides can dramatically affect their properties respect to receptor recognition, mechanism internalization, intracellular trafficking, and fate. Furthermore, investigations are needed better understand the whereby application an alternating field cells containing induces cell death. Here, we designed nanoplatform...
The ability to self-assemble was evaluated for a large variety of amphiphilic block copolymers, including poly(ethyleneoxide-b-ε-caprolactone), poly(ethyleneoxide-b-d,l-lactide), poly(ethyleneoxide-b-styrene), poly(ethyleneoxide-b-butadiene) and poly(ethyleneoxide-b-methylmethacrylate). Different methods formation are discussed, such as cosolvent addition, film hydration or electroformation. influence experimental parameters macromolecular structures on the size morphology final...
Metabolic syndrome can induce chronic kidney disease in humans. Genetically engineered mice on a C57BL/6 background are highly used for mechanistic studies. Although it has been shown that metabolic induces cardiovascular lesions mice, depth renal phenotyping never performed. Therefore this study we characterized function and injury with long-term induced by high fat fructose diet (HFFD). received an 8 months HFFD enriched (45% energy from fat) drinking water (30%). Body weight, food/water...
Interactions between dendritic cells and Mycobacterium tuberculosis, the aetiological agent of tuberculosis in humans, are thought to be central anti-mycobacterial immunity. We have previously shown that M. binds human monocyte-derived mostly through C-type lectin DC-SIGN (dendritic-cell-specific intercellular molecule-3-grabbing non-integrin)/CD209, we suggested may discriminate mycobacterial species recognition mannose-capping residues on lipoglycan lipoarabinomannan bacterial envelope....
Inorganic ultraviolet filters such as titanium dioxide (TiO(2)), safe to use on healthy skin, are often applied compromised and irradiated skin. The aim of this study was evaluate in vitro the cutaneous penetration TiO(2) nanoparticles (≥20 nm primary size), included a sunscreen, intact, damaged, irradiated, damaged/irradiated pigskin. Cutaneous localization after 24-h sunscreen application were investigated quantitatively using inductively coupled plasma-mass spectrometry, qualitatively...
Plant non-specific lipid transfer proteins (nsLTPs) belong to a complex multigenic family implicated in diverse physiological processes. However, their function and mode of action remain unclear probably because functional redundancy. Among the different roles proposed for nsLTPs, it has long been suggested that they could transport cuticular precursor across cell wall during formation cuticle, which constitutes first physical barrier plant interactions with aerial environment. Here, we took...
Thermoresponsive hydrogels were successfully prepared from poly(N-isopropylacrylamide)-based polymers with different architectures (linear, branched, or hyperbranched). The macromolecular strongly influence the internal structure of hydrogels, therefore modulating their thermoresponsive and rheological properties. These used for in situ synthesis gold nanoparticles. Significant changes hydrogel microstructures average pore size due to presence nanoparticles observed. Additionally,...
Tamoxifen is a selective estrogen receptor modulator widely used for the prophylactic treatment of breast cancer. In addition to (ER), tamoxifen binds with high affinity microsomal antiestrogen binding site (AEBS), which involved in ER-independent effects tamoxifen. present study, we investigate modulation biosynthesis cholesterol tumor cell lines by AEBS ligands. As consequence antitumoral drugs or PBPE, ligand, show that cells produced significant concentration- and time-dependent...
Abstract The microsomal antiestrogen-binding site (AEBS) is a high-affinity membranous binding for the antitumor drug tamoxifen that selectively binds diphenylmethane derivatives of such as PBPE and mediates their antiproliferative properties. AEBS hetero-oligomeric complex consisting 3β-hydroxysterol-Δ8-Δ7-isomerase 3β-hydroxysterol-Δ7-reductase. High-affinity ligands inhibit these enzymes leading to massive intracellular accumulation zymostenol or 7-dehydrocholesterol (DHC), thus linking...
We describe here the syntheses and biological properties of new alkylaminooxysterols. Compounds were synthesized through trans-diaxial aminolysis 5,6-α-epoxysterols with various natural amines including histamine, putrescine, spermidine, or spermine. The regioselective synthesis these 16 5α-hydroxyl-6β-aminoalkylsterols is presented. first screened for dendrite outgrowth cytotoxicity in vitro, two leads selected further characterized....
Abstract Mild thrombocytopenia, changes in platelet gene expression, enhanced functionality, and presence of platelet-rich thrombi the lung have been associated with thromboinflammatory complications patients COVID-19. However, whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) gets internalized by platelets directly alters their behavior function infected remains elusive. Here, we investigated parameters viral material from a prospective cohort 29 COVID-19 admitted to an...
Tamoxifen is a selective estrogen receptor modulator (SERM) used for the treatment and prevention of breast cancer. has been reported to protect against progression coronary artery diseases in human different atherosclerosis animal models by blocking appearance atheromatous plaque. However, molecular mechanism this effect remains unknown. Acyl-CoA:cholesterol acyl transferase (ACAT) catalyzes biosynthesis cholesteryl esters, which are major lipids found In paper we have tested whether ACAT...
Poly(ethylene oxide)−poly(propylene oxide)−poly(ethylene oxide) (PEO)x−(PPO)y−(PEO)x triblock copolymers have been efficiently used for the stabilization of gold nanoparticles (AuNps) in NaCl aqueous solutions. The effects concentration and structure block copolymer (i.e., PEO length, PPO overall length polymer) systematically investigated, using well-defined AuNps (diameter ∼12 nm) synthesized through a standard citrate reduction procedure. Aggregation precipitation processes were assessed...
Cardiac tissue cohesion relying on highly ordered cardiomyocytes (CM) interactions is critical because most cardiomyopathies are associated with remodeling and architecture alterations.Eph/ephrin system constitutes a ubiquitous coordinating cellular communications which recently emerged as major regulator in adult organs. We examined if eph/ephrin could participate cardiac cyto-organization.We reported the expression of ephrin-B1 both endothelial cells for first time CMs where localized...
Abstract Tumour cells are characterized by having lost their differentiation state. They constitutively secrete small extracellular vesicles (sEV) called exosomes when they come from late endosomes. Dendrogenin A (DDA) is an endogenous tumour suppressor cholesterol‐derived metabolite. It a new class of ligand the nuclear Liver X receptors (LXR) which regulate cholesterol homeostasis and immunity. We hypothesized that DDA, induces cell differentiation, inhibition growth immune infiltration...