A5055664477- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- SARS-CoV-2 detection and testing
- T-cell and B-cell Immunology
- interferon and immune responses
- HIV/AIDS drug development and treatment
- Cytomegalovirus and herpesvirus research
- Mosquito-borne diseases and control
- Herpesvirus Infections and Treatments
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- Bacillus and Francisella bacterial research
- Immune Response and Inflammation
- Viral Infections and Vectors
- Complement system in diseases
- HIV/AIDS Research and Interventions
- French Urban and Social Studies
- Viral Infections and Outbreaks Research
- Long-Term Effects of COVID-19
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Respiratory viral infections research
Institut Pasteur
2016-2025
Centre National de la Recherche Scientifique
2016-2025
Institut de Recherche Vaccinale
2016-2025
Université Paris Cité
1997-2025
Immunité et Cancer
2005-2025
Université Paris-Est Créteil
2020-2025
Department of Virology
2015-2024
Université Paris-Saclay
2024
Sorbonne Université
2023
Texas Children's Hospital
2023
Early specific antibody responses against SARS-CoV-2 include IgG, IgM, and IgA, but IgA may neutralize virus control infection to a larger extent.
Early interactions between lung dendritic cells (LDCs) and Mycobacterium tuberculosis, the etiological agent of are thought to be critical for mounting a protective anti-mycobacterial immune response determining outcome infection. However, these poorly understood, at least molecular level. Here we show that M. tuberculosis enters human monocyte-derived DCs after binding recently identified lectin DC-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN). By contrast,...
Ligation of CCR5 by the CC chemokines RANTES, MIP-1α or MIP-1β, and CXCR4 CXC chemokine SDF-1α, profoundly inhibits replication HIV strains that use these coreceptors for entry into CD4+ T lymphocytes. The mechanism inhibition is not known. We found a rapid extensive downregulation SDF-1α RANTES antagonist RANTES(9-68). Confocal laser scanning microscopy showed CXCR4, after binding to their ligands, are internalized vesicles qualify as early endosomes indicated colocalization with...
An unprecedented epidemic of chikungunya virus (CHIKV) infection recently started in countries the Indian Ocean area, causing an acute and painful syndrome with strong fever, asthenia, skin rash, polyarthritis, lethal cases encephalitis. The basis for disease tropism CHIKV remain unknown. Here, we describe replication characteristics recent clinical strains. Human epithelial endothelial cells, primary fibroblasts and, to a lesser extent, monocyte-derived macrophages, were susceptible allowed...
Dengue viruses (DVs) are responsible for the most medically relevant arboviral diseases. However, molecular interactions mediating DV entry poorly understood. We determined that TIM and TAM proteins, two receptor families mediate phosphatidylserine (PtdSer)-dependent phagocytic removal of apoptotic cells, serve as factors. Cells susceptible to robustly infected after ectopic expression or receptors. Conversely, infection cells is inhibited by anti-TIM anti-TAM antibodies knockdown...
Severe cases of COVID-19 are associated with extensive lung damage and the presence infected multinucleated syncytial pneumocytes. The viral cellular mechanisms regulating formation these syncytia not well understood. Here, we show that SARS-CoV-2-infected cells express Spike protein (S) at their surface fuse ACE2-positive neighboring cells. Expression S without any other proteins triggers formation. Interferon-induced transmembrane (IFITMs), a family restriction factors block entry many...
ABSTRACT An outbreak of the novel coronavirus SARS-CoV-2, causative agent COVID-19 respiratory disease, has infected over 290,000 people since end 2019, killed 12,000, and caused worldwide social economic disruption 1,2 . There are currently no antiviral drugs with proven efficacy nor there vaccines for its prevention. Unfortunately, scientific community little knowledge molecular details SARS-CoV-2 infection. To illuminate this, we cloned, tagged expressed 26 29 viral proteins in human...
ZIKA virus (ZIKV) is an emerging pathogen responsible for neurological disorders and congenital microcephaly. However, the molecular basis ZIKV neurotropism remains poorly understood. Here, we show that Axl expressed in human microglia astrocytes developing brain it mediates infection of glial cells. Axl-mediated entry requires ligand Gas6, which bridges particles to Following binding, internalized through clathrin-mediated endocytosis traffics Rab5+ endosomes establish productive infection....
Quiescent CD4+ T lymphocytes are highly refractory to HIV-1 infection due a block at reverse transcription. Examination of SAMHD1 expression in peripheral blood shows that is expressed both and CD8+ cells levels comparable those found myeloid cells. Treatment with Virus-Like Particles (VLP) containing Vpx results the loss correlates an increased permissiveness accumulation transcribed viral DNA without promoting transcription from LTR. Importantly, T-cells patients Aicardi-Goutières Syndrome...
Chikungunya virus (CHIKV) is the causative agent of an outbreak that began in La Réunion 2005 and remains a major public health concern India, Southeast Asia, southern Europe. CHIKV transmitted to humans by mosquitoes associated disease characterized fever, myalgia, arthralgia, rash. As viral load infected patients declines before appearance neutralizing antibodies, we studied role type I interferon (IFN) pathogenesis. Based on human studies mouse experimentation, show does not directly...
Abstract The SARS-CoV-2 B.1.617 lineage emerged in October 2020 India 1–6 . It has since then become dominant some indian regions and further spread to many countries. includes three main subtypes (B1.617.1, B.1617.2 B.1.617.3), which harbour diverse Spike mutations the N-terminal domain (NTD) receptor binding (RBD) may increase their immune evasion potential. B.1.617.2 is believed faster than other versions. Here, we isolated infectious from a traveller returning India. We examined its...
Different serological assays measuring anti–SARS-CoV-2 antibodies and their neutralizing activity in samples from individuals with severe mild COVID-19 are compared.
Significance Treatment of HIV-1 infection in humans is achieved using combinations highly effective antiretroviral therapy (ART) drugs to potently suppress viral replication and prevent the emergence drug-resistant viruses. However, ART must be taken indefinitely owing rapid return viremia upon termination treatment. Highly potent broadly neutralizing antibodies (bNAbs) present a new potential therapeutic modality treatment infection. Because their comparatively longer half-lives relative...