A5106124677- Immunodeficiency and Autoimmune Disorders
- Viral-associated cancers and disorders
- Platelet Disorders and Treatments
- Histiocytic Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Parvovirus B19 Infection Studies
- Cytomegalovirus and herpesvirus research
- Blood groups and transfusion
- SARS-CoV-2 and COVID-19 Research
- Complement system in diseases
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Blood disorders and treatments
- Adolescent and Pediatric Healthcare
- COVID-19 Impact on Reproduction
- Renal Diseases and Glomerulopathies
- Rangeland Management and Livestock Ecology
- Cystic Fibrosis Research Advances
- Gastrointestinal motility and disorders
- CNS Lymphoma Diagnosis and Treatment
- Animal Virus Infections Studies
- Agriculture and Biological Studies
- RNA modifications and cancer
Hôpital Saint-Louis
2019-2025
Assistance Publique – Hôpitaux de Paris
2019-2025
Université Paris Cité
2014-2023
Délégation Paris 7
2019-2021
Sorbonne Paris Cité
2021
Inserm
2020
Centre d'Immunologie et des Maladies Infectieuses
2020
Sorbonne Université
2020
Boston University
2019
Seattle University
2019
Early specific antibody responses against SARS-CoV-2 include IgG, IgM, and IgA, but IgA may neutralize virus control infection to a larger extent.
Abstract A major dogma in immunology has it that the IgM antibody response precedes secondary memory responses built on production of IgG, IgA and, occasionaly, IgE. Here, we measured acute humoral to SARS-CoV-2, including frequency antibody-secreting cells and presence specific, neutralizing, antibodies serum broncho-alveolar fluid 145 patients with COVID-19. Surprisingly, early SARS-CoV-2-specific were found be typically dominated by isotype. Peripheral expansion IgA-plasmablasts...
We retrospectively analysed 71 cases of Unicentric Castleman disease, a rare, usually asymptomatic, benign lymphoproliferative disorder presenting as unique nodal mass. Although surgery is considered the gold standard therapy, only 38 patients (54%) underwent initial surgical resection and 95% were cured. An additional 9 had after an attempt at medical reduction. Reduction therapy was used in 21 with 55% response rate, but without evidence for optimal regimen. Radiotherapy limited to 8...
Rituximab-resistant memory B cells and newly engaged naive join to fuel subsequent autoimmune responses in patients with relapsing ITP.
Here, we report on a heterozygous interferon regulatory factor 4 (IRF4) missense variant identified in three patients from multigeneration family with hypogammaglobulinemia. Patients' low blood plasmablast/plasma cell and naïve CD4 CD8 T counts contrasted high terminal effector counts. Expression of the mutant IRF4 protein control lymphoblastoid B lines reduced expression BLIMP-1 XBP1 (key transcription factors plasma differentiation). In lines, as wildtype was found to bind known binding...
Primary effusion lymphoma (PEL) is associated with human herpesvirus 8 and frequently Epstein-Barr virus (EBV). We report here a single-center series of 19 immunodeficiency virus–associated PELs, including 14 EBV + 5 − PELs. The objectives were to describe the clinicopathologic features focus on programmed cell death protein 1 (PD-1)/programmed death-ligand (PD-L1) expression, search for genetic alterations by targeted deep sequencing analysis, compare between cases. All patients male,...
Secretory IgA interacts with commensal bacteria, but its impact on human mycobiota ecology has not been widely explored. In particular, whether IgA-deficiency is associated gut fungal dysbiosis remains unknown. Our goal was to study the of ecology. The Fungi-Flow method used characterize fecal, systemic, and maternal IgA, IgM, IgG responses against 14 representative strains (yeast/spores or hyphae forms) in healthy donors (HDs) (n = 34, 31, 20, respectively) also compare opsonization by...
Idiopathic multicentric Castleman disease (iMCD) is a non-clonal inflammatory lymphoproliferative disorder of unknown origin. Recently, TAFRO syndrome (thrombocytopenia, anasarca, fever, reticulin fibrosis and organomegaly) emerged as singular variant iMCD in Asia was associated with severe course poor outcome. The present study describes the first large Western cohort patients (n = 25) meeting All Japan Syndrome Research Group diagnostic criteria. Characteristics were compared to iMCD-not...
Rituximab has revolutionized the treatment of Kaposi sarcoma-associated herpesvirus/human herpesvirus 8-associated multicentric Castleman disease (HHV8+ MCD), converting a rapidly fatal illness into relapsing disease. HHV8+ MCD mainly affects patients with HIV infection but can also be observed in without infection. We retrospectively analyzed cohort 99 (73 who tested HIV+ and 26 HIV-), treated rituximab-based therapy. Baseline characteristics were similar had HIV- results, although those...
Abstract Early thrombotic thrombocytopenic purpura (TTP) recognition is critical as this disease almost always lethal if not treated promptly with therapeutic plasma exchanges. Currently, ADAMTS13 (a disintegrin and metalloproteinase a thrombospondin type 1 motif, member 13) activity widely available in emergency, scores have been developed to help differentiating TTP from other microangiopathies (TMAs). The aim of work was study the accuracy these diagnostic intensive care unit (ICU)...
Key Points Autoimmune hypoglycemia belongs to the clinical spectrum of HHV8+ MCD and rituximab is an effective treatment this condition. This rare complication related autoantibodies directed toward insulin receptor activating signaling pathway.
Abstract Idiopathic multicentric Castleman disease (iMCD) is a lymphoproliferative of unknown etiology. Deciphering mechanisms involved in CD pathogenesis may help improving patients’ care. Six cases stereotyped sub‐diaphragmatic iMCD affecting lower limb‐draining areas and associated with severe often ulcerative extremity chronic dermatological condition were identified our cohort. Pathological examination revealed mixed or plasma‐cell type MCD. In three patients, shotgun metagenomics...