A5103197947- Health, Medicine and Society
- Diabetes and associated disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Healthcare Systems and Practices
- Diet and metabolism studies
- Diabetes Management and Education
- Metabolism, Diabetes, and Cancer
- Diabetic Foot Ulcer Assessment and Management
- Pituitary Gland Disorders and Treatments
- Bariatric Surgery and Outcomes
- Psychoanalysis and Psychopathology Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Wound Healing and Treatments
- Viral-associated cancers and disorders
- Cardiovascular Issues in Pregnancy
- Adrenal and Paraganglionic Tumors
- Parkinson's Disease Mechanisms and Treatments
- Adrenal Hormones and Disorders
- Peripheral Neuropathies and Disorders
- Cancer Immunotherapy and Biomarkers
- Gestational Diabetes Research and Management
- Pancreatic and Hepatic Oncology Research
Hôpital Lariboisière
2004-2023
Fondation de Rothschild
2023
Université Paris Cité
2008-2023
Assistance Publique – Hôpitaux de Paris
2008-2023
Hôpital Fernand-Widal
2017-2021
Fondation Ophtalmologique Adolphe de Rothschild
2021
Délégation Paris 7
2015-2017
Sorbonne Paris Cité
2017
Centre Hospitalier d'Albi
2015
Inserm
2002-2015
OBJECTIVE—To evaluate whether a 5-week low–glycemic index (LGI) diet versus high–glycemic (HGI) can modify glucose and lipid metabolism as well total fat mass in nondiabetic men. RESEARCH DESIGN AND METHODS—In this study, 11 healthy men were randomly allocated to 5 weeks of an LGI or HGI separated by washout interval crossover design. RESULTS—The resulted lower postprandial plasma insulin profiles areas under the curve (AUCs) than diet. A period lowered triacylglycerol excursion after lunch...
Islet β-cells express both insulin receptors and insulin-signaling proteins. Recent evidence from rodents in vivo islets isolated or humans suggests that the signaling pathway is physiologically important for glucose sensing. We evaluated whether regulates β-cell function healthy vivo. Glucose-induced secretion was assessed following 4-h saline (low insulin/sham clamp) isoglycemic-hyperinsulinemic (high insulin) clamps using B28-Asp could be immunologically distinguished endogenous insulin....
In normoglycemic offspring of two type 2 diabetic parents, low insulin sensitivity (S I ) and insulin-independent glucose effectiveness G predict the development diabetes one to decades later. To determine whether S , G, or acute response are predictive in a population at genetic risk for disease, 181 individuals with no family history (FH−) 150 parents (FH+) underwent i.v. tolerance testing (IVGTT) between years 1964–82. During 25 ± 6 follow-up, comprising 2,758 person years, FH− cohort (54...
Immune checkpoint inhibitors have improved survival in numerous advanced malignancies, but are associated with a number of immune-related adverse events, including endocrinopathies. Endogenous Cushing's syndrome (CS) is rare disorder resulting from exposure to high levels circulating cortisol. CS can be caused either by adrenal cortex tumors or hyperplasia pituitary extra-pituitary over-secreting ACTH (known as ACTH-dependent CS). We report the first case transient CS, which appeared after...
Uncoupling protein 2 (UCP2) is a physiological downregulator of reactive oxygen species generation and plays an antiatherogenic role in the vascular wall. A common variant UCP2 promoter (-866G>A) modulates mRNA expression, with increased expression associated allele. We investigated association this coronary artery disease (CAD) two cohorts type diabetic subjects.We studied 3,122 subjects from 6-year prospective Non-Insulin-Dependent Diabetes, Hypertension, Microalbuminuria, Cardiovascular...
Insulin resistance and glucose effectiveness (S(G)) are major determinants of tolerance independently predict the development type 2 diabetes in individuals with a family history disease. We examined inter-relationship between insulin sensitivity (S(I)) S(G) offspring two parents no diabetes.Fifty non-diabetic individuals, including 26 diabetic (family history, FH+) 24 (FH-) similar gender, age, ethnicity body mass index (BMI) were studied. Each subject underwent 100-g oral test (OGTT)...
Oral hypoglycemic agents bind to the ATP-sensitive potassium channel and lower glucose levels effectively in individuals with diabetes. Although principle mechanism of action can also promote hypoglycemia, clinically profound hypoglycemia is rare. Decreased stimulation insulin secretion by these at mild could provide protection from more hypoglycemia. Sulfonylureas meglitinides both shared unique sites on receptor/channel complex but have different pharmacokinetic profiles. To evaluate...
Hand washing before glucose and ketone fingerprick testing prevents false results in users of skin lightening cosmetics
Cognitive-behavioral therapy (CBT) is being used, individually or in group format, to improve outcome and prevent relapse of patients with bipolar disorder (BD). CBT shows nevertheless limitations regard, mainly, having undergone a great number mood episodes. In one published study, more than 12 episodes typically did not respond favorably the procedures, for some, their clinical condition worsened. Understandably, high dropout rate has also been observed other studies. Objectives To...
Key Points Autoimmune hypoglycemia belongs to the clinical spectrum of HHV8+ MCD and rituximab is an effective treatment this condition. This rare complication related autoantibodies directed toward insulin receptor activating signaling pathway.