Guillaume Mellon
A5050367455- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Tuberculosis Research and Epidemiology
- SARS-CoV-2 detection and testing
- Antibiotic Resistance in Bacteria
- Hepatitis C virus research
- Infectious Diseases and Tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 and Mental Health
- Antibiotic Use and Resistance
- Diagnosis and treatment of tuberculosis
- Hepatitis B Virus Studies
- Antibiotics Pharmacokinetics and Efficacy
- Bacillus and Francisella bacterial research
- Vaccine Coverage and Hesitancy
- Viral Infections and Outbreaks Research
- HIV-related health complications and treatments
- COVID-19 and healthcare impacts
- Emergency and Acute Care Studies
- Infection Control and Ventilation
- HIV/AIDS drug development and treatment
- Orthopedic Infections and Treatments
Assistance Publique – Hôpitaux de Paris
2014-2025
Université Paris Cité
2014-2025
Inserm
2020-2025
Sorbonne Université
2012-2025
Hôpital Saint-Louis
2017-2025
Sorbonne Paris Cité
2014-2025
Laboratoire Pluridisciplinaire de Recherche en Ingénierie des Systèmes, Mécanique et Energétique
2024-2025
Hôpital Raymond-Poincaré
2014-2024
Université Paris-Saclay
2021-2024
Hôpital Bichat-Claude-Bernard
2021-2022
We measured plasma and/or serum antibody responses to the receptor-binding domain (RBD) of spike (S) protein SARS-CoV-2 in 343 North American patients infected with (of which 93% required hospitalization) up 122 days after symptom onset and compared them 1548 individuals whose blood samples were obtained prior pandemic. After setting seropositivity thresholds for perfect specificity (100%), we estimated sensitivities 95% IgG, 90% IgA, 81% IgM detecting between 15 28 onset. While median time...
Different serological assays measuring anti–SARS-CoV-2 antibodies and their neutralizing activity in samples from individuals with severe mild COVID-19 are compared.
Characterizing the humoral immune response to SARS-CoV-2 and developing accurate serologic assays are needed for diagnostic purposes estimating population-level seroprevalence. We measured kinetics of early antibody responses receptor-binding domain (RBD) spike (S) protein in a cohort 259 symptomatic North American patients infected with (up 75 days after symptom onset) compared levels 1548 individuals whose blood samples were obtained prior pandemic. Between 14-28 from onset symptoms, IgG,...
Abstract It is of paramount importance to evaluate the prevalence both asymptomatic and symptomatic cases SARS-CoV-2 infection their antibody response profile. Here, we performed a pilot study assess levels anti-SARS-CoV-2 antibodies in samples taken from 491 pre-epidemic individuals, 51 patients Hôpital Bichat (Paris), 209 pauci-symptomatic individuals French Oise region 200 contemporary blood donors. Two in-house ELISA assays, that recognize full-length nucleoprotein (N) or trimeric Spike...
Patients with chronic kidney disease suffer from immune dysfunction, increasing susceptibility to infections. The aim of the study was investigate air contamination respiratory viruses in a dialysis unit at quaternary hospital using molecular detection techniques and analyze airflow dynamics through computational fluid (CFD) simulations for comprehensive assessment transmission risks. We conducted sampling AerosolSense™ samplers. Air clinical occurred during three periods 2022: winter,...
Abstract Background Burns intensive care units (BICU) have reduced mortality in burns patients, but infections and sepsis remain the leading causes of death. Infections with multidrug-resistant (MDR) bacteria increase risk death whose acquiring such is higher due to various factors, including prolonged hospitalization invasive procedures. Methods A retrospective study was performed a French BICU over eight years, analyze epidemiology factors for bloodstream (BSI). Results In total, 1402...
The genome of the Omicron variant concern (VOC) contains more than 50 mutations, many which have been associated with increased transmissibility, differing disease severity, and potential to elute immune responses acquired after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination or infection previous VOCs. Due a better tropism for upper tract, it was suggested that detection could be preferred in saliva, compared nasopharyngeal swabs (NPS). Our objective compare...
Failure of treatment is the most serious complication in community-acquired pneumonia (CAP).To assess potential risk factors for failure clinically stable patients with CAP.This secondary analysis assesses data from a randomized clinical trial on CAP (Pneumonia Short Treatment [PTC] trial) conducted December 19, 2013, to February 1, 2018. Data was performed July 18, 2019, 15, 2020. Patients hospitalized at 1 16 centers France moderately severe who were day 3 antibiotic included PTC and...
We report 20 cases of extensively drug-resistant tuberculosis managed in France. Treatment was individualized and included bedaquiline linezolid for most patients surgery 8 patients. At last follow-up (22 months), 19 had achieved conversion from positive to negative on culture testing. These promising results comprehensive management obtained a small series deserve confirmation.
Abstract Background Pneumonia, skin and soft tissue infections are more frequent in obese patients most often treated by co-amoxiclav, using similar dosing regimens to those used for non-obese subjects. No data available on amoxicillin pharmacokinetics among subjects receiving co-amoxiclav. Materials methods Prospective, single-centre, open-label, non-randomized, crossover pharmacokinetic trial having enrolled otherwise healthy adult A first dose of co-amoxiclav (amoxicillin/clavulanate...
Only a few late cases of Plasmodium ovale presentation have been reported in literature. We describe two P. occurring French military personnel, 47 and 69 months, respectively, after stay Côte d'Ivoire the absence new intercurrent malaria exposure.
INTRODUCTION: In France, young adults are legally freed from parental authority at the age of 18 years and are, thus, responsible for their own vaccine record. This adult population is more frequently exposed to vaccine‐preventable infectious diseases. OBJECTIVE: To determine factors associated with students’ knowledge interval between two antitetanus boosters report having up‐to‐date vaccinations. METHODS: April 2009, a survey was conducted involving random sample students 25 eating lunch...