Solen Kernéis
A5014403667- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- SARS-CoV-2 detection and testing
- Pneumonia and Respiratory Infections
- Infection Control and Ventilation
- Bacterial Identification and Susceptibility Testing
- Long-Term Effects of COVID-19
- Antimicrobial Resistance in Staphylococcus
- COVID-19 epidemiological studies
- COVID-19 and Mental Health
- COVID-19 and healthcare impacts
- Orthopedic Infections and Treatments
- Influenza Virus Research Studies
- Infective Endocarditis Diagnosis and Management
- Vaccine Coverage and Hesitancy
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Respiratory viral infections research
- Streptococcal Infections and Treatments
- Nosocomial Infections in ICU
- Biosensors and Analytical Detection
- Healthcare Systems and Practices
Inserm
2015-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Université Paris Cité
2016-2025
Sorbonne Paris Cité
2015-2025
Hôpital Bichat-Claude-Bernard
2020-2025
Laboratoire de Recherche Vasculaire Translationnelle
2024
Hôpital Cochin
2014-2023
Sorbonne Université
2010-2023
Université Claude Bernard Lyon 1
2021-2023
Centre d'Immunologie et des Maladies Infectieuses
2016-2023
Interferons interfere with lung repair (IFNs) are central to antiviral immunity. Viral recognition elicits IFN production, which in turn triggers the transcription of IFN-stimulated genes (ISGs), engage various functions. Type I IFNs (IFN-α and IFN-β) widely expressed can result immunopathology during viral infections. By contrast, type III (IFN-λ) responses primarily restricted mucosal surfaces thought confer protection without driving damaging proinflammatory responses. Accordingly, IFN-λ...
To assess the effectiveness of hydroxychloroquine in patients admitted to hospital with coronavirus disease 2019 (covid-19) pneumonia who require oxygen. Comparative observational study using data collected from routine care. Four French tertiary care centres providing covid-19 between 12 March and 31 2020. 181 aged 18-80 years documented severe acute respiratory syndrome 2 (SARS-CoV-2) required oxygen but not intensive Hydroxychloroquine at a dose 600 mg/day within 48 hours admission...
The increasing volume of research by the medical community often leads to numbers contradictory findings and conclusions. Although differences observed may represent true differences, results also differ because sampling variability as all studies are performed on a limited number specimens or patients. When planning study reporting among groups patients describing some variable in single group, sample size should be considered it allows researcher control for risk false-negative finding...
Abstract Background Coronavirus disease 2019 (Covid-19) is a major global threat that has already caused more than 100,000 deaths worldwide. It characterized by distinct patterns of progression implying diverse host immune response. However, the immunological features and molecular mechanisms involved in Covid-19 severity remain so far poorly known. Methods We performed an integrated analysis included in-depth phenotypical profiling cells, whole-blood transcriptomic cytokine quantification...
Abstract Coordinated local mucosal and systemic immune responses following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection either protect against disease 2019 (COVID-19) pathologies or fail, leading to clinical outcomes. To understand this process, we performed an integrated analysis of SARS-CoV-2 spike-specific antibodies, cytokines, viral load bacterial communities in paired nasopharyngeal swabs plasma samples from a cohort clinically distinct patients with COVID-19...
OBJECTIVES Many factors influence the career specialty decisions made by medical students. The aim of this study was to broaden consideration determinants choice in a large population students their sixth year study. METHODS A total 2588 distributed across all 39 schools France participated National Practice Examination December 2008, after which an electronic questionnaire administered. Study criteria were: characteristics; demographics, and motivation for drawbacks choice. RESULTS 1780...
In Brief Objectives: To evaluate the results of a vertical rectus abdominis myocutaneus (VRAM) flap after abdomino-perineal resection (APR) for anal cancer (AC). Background Data: APR is only curative treatment AC that recurs or persists radiochemotherapy. obtain clear surgical margin, frequently includes significant perineal exenteration, leaving large defect surrounded by irradiated tissue. VRAM may facilitate healing such wound and, providing tissue can cover defect, wide and thus...
Ability to identify patients with familial adenomatous polyposis who have a high risk of developing desmoid tumors may affect decisions in clinical practice.Our aim was assess several factors for tumor development an international cohort and evaluate the relevance factors.This retrospective study.Polyposis registries The Netherlands, France, Denmark, Finland, Italy provided information on tumors.We used univariate multivariable analyses data from Finland test whether gender, APC mutation...
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces an antibody response targeting multiple antigens that changes over time. This study aims to take advantage of this complexity develop more accurate serological diagnostics.A multiplex assay was developed measure IgG and IgM responses seven SARS-CoV-2 spike or nucleoprotein antigens, two for the nucleoproteins 229E NL63 seasonal coronaviruses, three non-coronavirus antigens. Antibodies were measured in serum...
Coronavirus disease 2019 (COVID-19) is a global public health problem that has already caused more than 662 000 deaths worldwide. Although the clinical manifestations of COVID-19 are dominated by respiratory symptoms, some patients present other severe damage such as cardiovascular, renal and liver injury, and/or multiple organ failure, suggesting spread acute syndrome coronavirus 2 (SARS-CoV-2) in blood. Recent ultrasensitive polymerase chain reaction (PCR) technology now allows absolute...
Improving timeliness of pathogen identification is crucial to allow early adaptation antibiotic therapy and improve prognosis in patients with pneumonia. We evaluated the relevance a new syndromic rapid multiplex PCR test (rm-PCR) on respiratory samples guide empirical antimicrobial adult community-acquired pneumonia (CAP), hospital-acquired (HAP), ventilator-acquired (VAP).This retrospective multicenter study was conducted four French university hospitals. Respiratory were obtained from...
Abstract Background Microvascular, arterial and venous thrombotic events have been largely described during severe coronavirus disease 19 (COVID-19). However, mechanisms underlying hemostasis dysregulation remain unclear. Methods We explored two independent cross-sectional cohorts to identify soluble markers gene-expression signatures that discriminated COVID-19 severity outcomes. Results found elevated (s)P-selectin at admission was associated with severity. Elevated sP-selectin predictive...
This cross-sectional study uses surveillance data to assess temporal trends in suicide attempts among children admitted a pediatric emergency department Paris, France, the decade before and during COVID-19 pandemic.
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a complex antibody response that varies by orders of magnitude between individuals and over time.
Mass indoor gatherings were banned in early 2020 to prevent the spread of SARS-CoV-2. We aimed assess, under controlled conditions, whether infection rates among attendees at a large, gathering event would be similar those non-attendees, given implementation comprehensive prevention strategy including antigen-screening within 3 days, medical mask wearing, and optimised ventilation.