A5062648346- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Long-Term Effects of COVID-19
- Dermatological and COVID-19 studies
- interferon and immune responses
- Immune Response and Inflammation
- Inflammasome and immune disorders
- Cell death mechanisms and regulation
- Phagocytosis and Immune Regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Respiratory viral infections research
- Autoimmune and Inflammatory Disorders
- Immune responses and vaccinations
- Autophagy in Disease and Therapy
- Systemic Lupus Erythematosus Research
- Streptococcal Infections and Treatments
- Venous Thromboembolism Diagnosis and Management
- COVID-19 and healthcare impacts
- NF-κB Signaling Pathways
- Inflammatory Biomarkers in Disease Prognosis
- Melanoma and MAPK Pathways
Université Paris Cité
2015-2025
Institut Pasteur
2015-2025
Icahn School of Medicine at Mount Sinai
2024-2025
Tisch Hospital
2024
Hôpital Bichat-Claude-Bernard
2024
Hôpital Saint-Louis
2020-2023
Hôpital Cochin
2020-2023
Assistance Publique – Hôpitaux de Paris
2020-2021
Inserm
2011-2021
Hôpital Avicenne
2020
Interferons interfere with lung repair (IFNs) are central to antiviral immunity. Viral recognition elicits IFN production, which in turn triggers the transcription of IFN-stimulated genes (ISGs), engage various functions. Type I IFNs (IFN-α and IFN-β) widely expressed can result immunopathology during viral infections. By contrast, type III (IFN-λ) responses primarily restricted mucosal surfaces thought confer protection without driving damaging proinflammatory responses. Accordingly, IFN-λ...
Dying to impress the immune system Besides reacting microbes, T cells can also mount responses fragments of dying cells, which they encounter displayed on dendritic cells. Not all activate however, so what differentiates that do? Yatim et al. studied two forms programmed death: apoptosis and necroptosis. Using mouse in culture models inflammatory cell death anti-tumor immunity, found initiated immunity only when signaled through enzyme RIPK1 transcription factor NF-κB. Science , this issue p. 328
Programmed necrosis (or necroptosis) is a form of cell death triggered by the activation receptor interacting protein kinase-3 (RIPK3). Several reports have implicated mitochondria and mitochondrial reactive oxygen species (ROS) generation as effectors RIPK3-dependent death. Here, we directly test this idea employing method for specific removal via mitophagy. Mitochondria-deficient cells were resistant to pathway apoptosis, but efficiently died tumor factor (TNF)-induced, programmed or...
Abstract Background Coronavirus disease 2019 (Covid-19) is a major global threat that has already caused more than 100,000 deaths worldwide. It characterized by distinct patterns of progression implying diverse host immune response. However, the immunological features and molecular mechanisms involved in Covid-19 severity remain so far poorly known. Methods We performed an integrated analysis included in-depth phenotypical profiling cells, whole-blood transcriptomic cytokine quantification...
Coronavirus disease-2019 (COVID-19), a respiratory disease has been associated with ischemic complications, coagulation disorders, and an endotheliitis. To explore endothelial damage activation-related biomarkers in COVID-19 patients criteria of hospitalization for referral to intensive care unit (ICU) and/or worsening. Analysis angiogenic soluble markers plasma from at admission. Study enrolled 40 consecutive admitted emergency department that fulfilled hospitalization. Half them were...
Abstract Coordinated local mucosal and systemic immune responses following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection either protect against disease 2019 (COVID-19) pathologies or fail, leading to clinical outcomes. To understand this process, we performed an integrated analysis of SARS-CoV-2 spike-specific antibodies, cytokines, viral load bacterial communities in paired nasopharyngeal swabs plasma samples from a cohort clinically distinct patients with COVID-19...
Age is a major risk factor for cancer, but how aging impacts tumor control remains unclear. In this study, we establish that of the immune system, regardless age stroma and tumor, drives lung cancer progression. Hematopoietic enhances emergency myelopoiesis, resulting in local accumulation myeloid progenitor–like cells tumors. These are source interleukin (IL)–1⍺, which enhanced response. The age-associated decline DNA methyltransferase 3A IL-1⍺ production, disrupting IL-1 receptor 1...
CD8+ T cells mediate antigen-specific immune responses that can induce rejection of solid tumors. In this process, dendritic (DCs) are thought to take up tumor antigens, which processed into peptides and loaded onto MHC-I molecules, a process called "cross-presentation." Neither the actual contribution cross-presentation antitumor nor intracellular pathways involved in vivo clearly established because lack experimental tools manipulate process. To develop such tools, we generated mice...
Highlights•RIPK3 activation induces both necroptotic cell death and cytokine production•Cytokine mRNA continues to be translated even after plasma membrane rupture•mRNA translation requires ER function, which remains rupture•Continued synthesis contributes the immune response cellsSummaryNecroptosis is a form of programmed that defined by kinase RIPK3 subsequent permeabilization effector MLKL. can also promote responses via production cytokines chemokines. How active coordinated with...
Abstract Background Microvascular, arterial and venous thrombotic events have been largely described during severe coronavirus disease 19 (COVID-19). However, mechanisms underlying hemostasis dysregulation remain unclear. Methods We explored two independent cross-sectional cohorts to identify soluble markers gene-expression signatures that discriminated COVID-19 severity outcomes. Results found elevated (s)P-selectin at admission was associated with severity. Elevated sP-selectin predictive...
Abstract Host immunity to infection with SARS-CoV-2 is highly variable, dictating diverse clinical outcomes ranging from asymptomatic severe disease and death. We previously reported reduced type I interferon in COVID-19 patients preceded worsening. Further studies identified genetic mutations loci of the TLR3- or TLR7-dependent interferon-I pathways, neutralizing autoantibodies as risk factors for development pneumonia. Here we show patient cohorts different severities COVID-19, that...
BackgroundThe outbreak of chilblain‐like lesions (CLL) during the COVID‐19 pandemic has been reported extensively, potentially related to SARS‐CoV‐2 infection, yet its underlying pathophysiology is unclear.
Abstract The cholinergic system has been proposed as a potential regulator of COVID-19-induced hypercytokinemia. We investigated whole-blood expression members and correlated it with COVID-19 severity. Patients confirmed SARS-CoV-2 infection healthy aged-matched controls were included in this non-interventional study. A whole blood sample was drawn between 9–11 days after symptoms onset, peripheral leukocyte phenotyping, cytokines measurement, RNA plasma viral load determined. Additionally,...
Immune checkpoint inhibitors for melanoma improve adaptive T cell immunity during COVID-19 without exacerbating inflammation.
Objective The clinical relevance of antiphospholipid antibodies (aPLs) in COVID‐19 is controversial. This study was undertaken to investigate the prevalence and prognostic value conventional nonconventional aPLs patients with COVID‐19. Methods a multicenter, prospective observational French cohort hospitalized suspected Results Two hundred forty‐nine were COVID‐19, whom confirmed 154 not 95. We found significant increase lupus anticoagulant (LAC) positivity among compared without (60.9%...
Abstract Introduction: Chronic inflammation can contribute to growth and immune evasion of solid tumors, with multiple cytokines chemokines implicated in this process. We previously showed that disrupting the Th2 response systemically by blocking IL-4 signaling activate dendritic cells T effector generate a robust against tumor antigens pre-clinical lung cancer models (Maier, B., et al., A conserved dendritic-cell regulatory program limits anti-tumour immunity. Nature,...