Aurélien Corneau
A5087186359- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- HIV Research and Treatment
- Single-cell and spatial transcriptomics
- Myasthenia Gravis and Thymoma
- COVID-19 Clinical Research Studies
- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 and COVID-19 Research
- Muscle Physiology and Disorders
- Cancer Immunotherapy and Biomarkers
- Inflammasome and immune disorders
- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- Cytomegalovirus and herpesvirus research
- Immune cells in cancer
- Immune Response and Inflammation
- Otitis Media and Relapsing Polychondritis
- Kawasaki Disease and Coronary Complications
- Cell Image Analysis Techniques
- COVID-19 and healthcare impacts
- Histiocytic Disorders and Treatments
- Viral Infections and Vectors
- IL-33, ST2, and ILC Pathways
- Extracellular vesicles in disease
Pitié-Salpêtrière Hospital
2018-2025
Sorbonne Université
2016-2025
Centre de Recherche Saint-Antoine
2024
Production et analyse de données en sciences de la vie et en santé
2018-2022
Inserm
2016-2022
Université Paris Cité
2021-2022
Centre de Recherche en Myologie
2022
Institut de Recherche en Sciences de la Santé
2020-2021
Infectious Disease Models and Innovative Therapies
2012-2019
École Pratique des Hautes Études
2016-2018
Interferons interfere with lung repair (IFNs) are central to antiviral immunity. Viral recognition elicits IFN production, which in turn triggers the transcription of IFN-stimulated genes (ISGs), engage various functions. Type I IFNs (IFN-α and IFN-β) widely expressed can result immunopathology during viral infections. By contrast, type III (IFN-λ) responses primarily restricted mucosal surfaces thought confer protection without driving damaging proinflammatory responses. Accordingly, IFN-λ...
The genetics underlying severe COVID-19 immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals lack specific IFNs can be more susceptible to infectious diseases. Furthermore, the autoantibody dampens IFN response prevent damage from pathogen-induced inflammation. Two studies now examine likelihood affects risk of coronavirus disease 2019 (COVID-19) through components this (see Perspective by Beck Aksentijevich). Q....
Abstract Background Coronavirus disease 2019 (Covid-19) is a major global threat that has already caused more than 100,000 deaths worldwide. It characterized by distinct patterns of progression implying diverse host immune response. However, the immunological features and molecular mechanisms involved in Covid-19 severity remain so far poorly known. Methods We performed an integrated analysis included in-depth phenotypical profiling cells, whole-blood transcriptomic cytokine quantification...
Abstract Acquired mutations in the UBA1 gene were recently identified patients with severe adult-onset auto-inflammatory syndrome called VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic). However, precise physiological and clinical impact of these remains poorly defined. Here we study a unique prospective cohort patients. We show that monocytes from are quantitatively qualitatively impaired display features exhaustion aberrant expression chemokine receptors. In peripheral...
The recent introduction of mass cytometry, a technique coupling cell system generating stream single cells with spectrometry, has greatly increased the number parameters that can be measured per cell. As all new technology there is need for dissemination standardization and quality control procedures. Here, we characterize variations in sensitivity observed across range cytometer, using different lanthanide tags. We five-fold difference detection over demonstrated each instrument its own...
Rationale: Sepsis is the leading cause of death in adult ICUs. At present, sepsis diagnosis relies on nonspecific clinical features. It could transform care to have immune-cell biomarkers that predict and guide treatment. For decades, neutrophil phenotypes been studied sepsis, but a diagnostic cell subset has yet be identified. Objectives: To identify an early, specific immune signature severity does not overlap with other inflammatory distinguishes patients from those noninfectious...
Immune checkpoint inhibitors for melanoma improve adaptive T cell immunity during COVID-19 without exacerbating inflammation.
Abstract Background Fibrosis is defined as an excessive accumulation of extracellular matrix (ECM) components. Many organs are subjected to fibrosis including the lung, liver, heart, skin, kidney, and muscle. Muscle occurs in response trauma, aging, or dystrophies impairs muscle function. represents a hurdle for treatment human muscular dystrophies. While data on mechanisms have mostly been investigated mice, dystrophic mouse models often do not recapitulate observed patients. Consequently,...
Loss of NBEAL2 function leads to grey platelet syndrome (GPS), a bleeding disorder characterized by macro-thrombocytopenia and α-granule-deficient platelets. A proportion patients with GPS develop autoimmunity through an unknown mechanism, which might be related the proteins interacts with, specifically in immune cells. Here we show comprehensive interactome primary T cells, based on mass spectrometry identification altogether 74 protein association partners. These include LRBA, member same...
The mucosal events of HIV transmission have been extensively studied, but the role infected cells present in genital and rectal secretions, semen, particular, remains a matter debate. As prerequisite to thorough vivo investigation early through cells, we characterized detail by multi-parameter flow cytometry changes macaque seminal leukocytes during SIVmac251 infection, focusing on T macrophages dendritic cells. Using immunocytofluorescence targeting SIV proteins real-time quantitative PCR...
IFN-I production is a characteristic of HIV/SIV primary infections. However, acute plasma concentrations rapidly decline thereafter. Plasmacytoid dendritic cells (pDC) are key players in this but infection associated with decreased responsiveness pDC to TLR 7 and 9 triggering. IFNα during SIV contrasts increased death, renewal dysfunction. We investigated the contribution dynamics both rapid return pre-infection levels acute-to-chronic transition. Nine cynomolgus macaques were infected...
IKKα, encoded by CHUK, is crucial in the non-canonical NF-κB pathway and part of IKK complex activating canonical alongside IKKβ. The absence IKKα causes fetal encasement syndrome humans, fatal utero, while an impaired IKKα-NIK interaction was reported a single patient combined immunodeficiency. Here, we describe compound heterozygous variants kinase domain female with hypogammaglobulinemia, recurrent lung infections, Hay–Wells syndrome-like features. We showed that both were...
The importance of the adaptive T cell response in control and resolution viral infection has been well established. However, nature cell–mediated mechanisms life-threatening stages COVID-19 yet to be determined. aim present study was determine function phenotype populations associated with survival or death patients intensive care as a result phenotypic functional profiling by mass cytometry. Increased frequencies circulating, polyfunctional CD4+CXCR5+HLA-DR+ stem memory cells (Tscms)...
The spontaneous control of human and simian immunodeficiency viruses (HIV/SIV) is typically associated with specific major histocompatibility complex (MHC) class I alleles efficient CD8(+) T-cell responses, but many controllers maintain viral despite a nonprotective MHC background weak responses. Therefore, the contribution this response to maintaining long-term remains unclear. To address question, we transiently depleted T cells from five SIV-infected cynomolgus macaques Among them, only...
Uterus transplantation (UTx) is an emerging therapy for women with uterine infertility. However, critical questions remain this procedure including the mechanisms involved in graft rejection.
BACKGROUNDDonor cell engraftment is a prerequisite of successful allogeneic hematopoietic stem transplantation. Based on peripheral blood analyses, it characterized by early myeloid recovery and T B lymphopenia. However, cellular networks associated with bone marrow human cells have been poorly described.METHODSMass cytometry CITE-Seq analyses were performed 3 months after transplantation in patients acute myelogenous leukemia.RESULTSMass cytometric 26 20 healthy controls disclosed profound...