Mohammed F. Alosaimi
A5026771122- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Diabetes and associated disorders
- Long-Term Effects of COVID-19
- interferon and immune responses
- Blood disorders and treatments
- Immune Response and Inflammation
- NF-κB Signaling Pathways
- Cytomegalovirus and herpesvirus research
- Neonatal Respiratory Health Research
- Autoimmune and Inflammatory Disorders Research
- Viral-associated cancers and disorders
- IoT and Edge/Fog Computing
- Parvovirus B19 Infection Studies
- T-cell and B-cell Immunology
- Virus-based gene therapy research
- Viral Infections and Outbreaks Research
- Thyroid Disorders and Treatments
- Wound Healing and Treatments
- Adenosine and Purinergic Signaling
- Privacy-Preserving Technologies in Data
- SARS-CoV-2 detection and testing
- Dental Erosion and Treatment
King Saud University
2018-2025
Cardiff University
2023
King Khalid University Hospital
2021-2023
Umm al-Qura University
2021
King Abdul Aziz University Hospital
2021
Boston Children's Hospital
2018-2020
Harvard University
2018-2020
The genetics underlying severe COVID-19 immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals lack specific IFNs can be more susceptible to infectious diseases. Furthermore, the autoantibody dampens IFN response prevent damage from pathogen-induced inflammation. Two studies now examine likelihood affects risk of coronavirus disease 2019 (COVID-19) through components this (see Perspective by Beck Aksentijevich). Q....
Abstract Background We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent interferon (IFN) immunity or autoantibodies against IFN, account for 15–20% cases life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants remain be identified ~ 80% cases. Methods report here a genome-wide rare variant burden association analysis 3269 patients with COVID-19, 1373 SARS-CoV-2-infected individuals without pneumonia. Among 928...
Human cells homozygous for rare loss-of-expression (LOE) TYK2 alleles have impaired, but not abolished, cellular responses to IFN-α/β (underlying viral diseases in the patients) and IL-12 IL-23 mycobacterial diseases). Cells common P1104A allele selectively impaired isolated disease). We report three new forms of deficiency six patients from five families (R864C, G996R, G634E, or G1010D) compound heterozygous a (A928V). All these missense encode detectable proteins. The R864C G1010D are...
STAT2 is a transcription factor activated by type I and III interferons. We report 23 patients with loss of function variants causing autosomal recessive (AR), complete deficiency. Both cells transfected mutant alleles the patients' display impaired expression interferon stimulated genes control in-vitro viral infections. Clinical manifestations from early childhood onward include severe adverse reaction to live attenuated vaccines (LAV, 12/17 patients) infections (10/23 patients),...
Background Post-acute coronavirus disease 2019 (COVID-19) syndrome, also known as long COVID, is a prolonged illness after the acute phase of COVID-19. Hospitalized patients were to have persisting symptoms fatigue, headache, dyspnea, and anosmia. There need describe characteristics individuals with post-COVID-19 in comparison baseline characteristics. Purpose To investigate clinical biochemical people who recovered from COVID-19 6 months discharge hospital. Methods This was prospective...
Patients with inherited CARMIL2 or CD28 deficiency have defective T cell signaling, but their immunological and clinical phenotypes remain largely unknown. We show that only one of three isoforms is produced functional across leukocyte subsets. Tested mutant alleles from 89 patients 52 families impair canonical NF-κB not AP-1 NFAT activation in cells stimulated via CD28. Like CD28-deficient patients, CARMIL2-deficient display recalcitrant warts low blood counts CD4+ CD8+ memory TREGs. Unlike...
<title>Abstract</title> Objective To achieve consensus on the definition and clinical approach of Monogenic Inflammatory Immune Dysregulation Disorders (MIIDDs), a collective term for rare conditions marked by inflammation, immune dysregulation, infection susceptibility. Methods A multi-step, evidence-based, multidisciplinary process was employed, consisting of: 1) systematic literature review across four electronic databases (Cochrane Library, Web Science, Scopus, MEDLINE via PubMed),...
There are limited data on the efficacy and safety of favipiravir antiviral in coronavirus disease 2019 (COVID-19), particularly more progressed phase. This study aims to evaluate effect reducing length hospital stay in-hospital mortality among moderate severe hospitalized COVID-19 patients.A prospective, multicenter observational was conducted that included adult patients four major regions (Riyadh (Riyadh), Eastern (Dammam), Al-Qassem (Buraydah), Macca (Jeddah) Saudi Arabia. For primary...
CBL-B is an E3 ubiquitin ligase that ubiquitinates proteins downstream of immune receptors to downregulate positive signaling cascades. Distinct homozygous mutations in CBLB were identified 3 unrelated children with early-onset autoimmunity, one whom also had chronic urticaria. Patient T cells exhibited hyperproliferation response anti-CD3 cross-linking. One the mutations, p.R496X, abolished expression, and a second mutation, p.C464W, resulted preserved expression. The third p.H285L SH2...
The severe manifestation of coronavirus disease 2019 (COVID-19) is known to be mediated by several cytokines and chemokines. study aimed compare the early cytokine profile mild COVID-19 patients that with COVID-19-like symptoms tested negative for Severe Acute Respiratory Syndrome Coronavirus-2 in Reverse-Transcriptase Polymerase Chain Reaction (RT-PCR) test.This was a prospective, observational on admitted King Khalid University Hospital, Saud Medical City from June November 2020. Clinical...
COVID-19 is diagnosed using RT-PCR assays of samples from nasal and oropharyngeal swabs. People with negative often presented clinical manifestations COVID-19. The data on such patients are lacking. present study aims to characterize the who were suspected cases tested in compared had been positive.This a retrospective, observational adult confirmed admitted King Saud University Medical City, Riyadh, Saudi Arabia, 1st March 2020 until 30th November 2020. Laboratory confirmation done through...
Enamel demineralization and white-spot lesions (WSLs) around the orthodontic brackets are common clinical complications after fixed appliance therapy. WSLs form mainly due to plaque deposition during treatment period. This study was designed compare evaluate efficacy of two different remineralization agents on WSLs, which “Clinpro 5000 Colgate Sensitive Pro-Relief”. 27 caries-free human premolar teeth were collected extraction for purposes. The crowns set in acrylic resin, entire surfaces...
Cardiovascular disease is one of the main causes hospital admission and mortality, thyroid dysfunction increases risk developing acute or exacerbation chronic cardiac conditions. The aim this study to investigate prevalence hormone abnormality among patients in care unit (CCU) its relation diagnosis, clinical, biochemical data, hospital-related outcomes.We conducted a retrospective cohort observational that included adult who were admitted CCU. We excluded those with known received...