Klaus Warnatz
A5032056056- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Blood disorders and treatments
- Cystic Fibrosis Research Advances
- Chronic Lymphocytic Leukemia Research
- Platelet Disorders and Treatments
- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Vasculitis and related conditions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Autoimmune and Inflammatory Disorders Research
- NF-κB Signaling Pathways
- Diabetes and associated disorders
- Immunotherapy and Immune Responses
- Pediatric health and respiratory diseases
- Blood groups and transfusion
- Otitis Media and Relapsing Polychondritis
- IgG4-Related and Inflammatory Diseases
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Sarcoidosis and Beryllium Toxicity Research
- IL-33, ST2, and ILC Pathways
University Medical Center Freiburg
2016-2025
University of Freiburg
2016-2025
University Hospital of Zurich
2022-2024
Weatherford College
2023
University of Wuppertal
2023
University Hospital in Motol
2022
Center for Rheumatology
2002-2020
Centre for Chronic Disease Control
2009-2019
Boston Children's Hospital
2016
University of Fribourg
2012
Chronic mucocutaneous candidiasis may be manifested as a primary immunodeficiency characterized by persistent or recurrent infections of the mucosa skin with candida species. Most cases are sporadic, but both autosomal dominant inheritance and recessive have been described.
High-dose immunosuppressive therapy and autologous hematopoietic stem cell transplantation (HSCT) have shown efficacy in systemic sclerosis phase 1 small 2 trials.To compare safety of HSCT vs 12 successive monthly intravenous pulses cyclophosphamide.The Autologous Stem Cell Transplantation International Scleroderma (ASTIS) trial, a 3, multicenter, randomized (1:1), open-label, parallel-group, clinical trial conducted 10 countries at 29 centers with access to European Group for Blood Marrow...
To update the European League Against Rheumatism (EULAR) recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD) published 2011. Four systematic literature reviews were performed regarding incidence/prevalence of vaccine-preventable infections among AIIRD; efficacy, immunogenicity and safety vaccines; effect anti-rheumatic drugs on response to household AIIRDs patients. Subsequently, formulated based evidence expert opinion. The updated...
ICOS is expressed on activated T cells and particularly CXCR5+ follicular Th in germinal centers (GC). Its deletion leads to a profound deficiency memory B cell formation switched Ab response humans. Here, we show that ICOS-deficient patients the generation of GCs severely disturbed, numbers circulating CXCR5+CD45RO+ CD4 are significantly reduced, indicating an essential role differentiation CXCR5+CD4 cells. The GC-specific CD57+CXCR5+ subpopulation virtually absent. In ICOS-/- mice,...
B-cell survival depends on signals induced by activating factor (BAFF) binding to its receptor (BAFF-R). In mice, mutations in BAFF or BAFF-R cause lymphopenia and antibody deficiency. Analyzing expression BAFF-binding B cells common variable immunodeficiency (CVID) patients, we identified two siblings carrying a homozygous deletion the gene. Removing most of transmembrane part, precludes expression. Without BAFF-R, development is arrested at stage transitional numbers all subsequent stages...
There is uncertainty about the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in individuals with rare inborn errors immunity (IEI), a population at risk developing disease 2019. This relevant not only for these patients but also general population, because studies IEIs can unveil key requirements host defense.
The homeostasis of circulating B cell subsets in the peripheral blood healthy adults is well regulated, but disease it can be severely disturbed. Thus, a subgroup patients with common variable immunodeficiency (CVID) presents an extraordinary expansion unusual population characterized by low expression CD21. CD21 cells are polyclonal, unmutated IgM + IgD carry highly distinct gene profile which differs from conventional naïve cells. Interestingly, while clearly not representing memory...
T cell–derived IFNγ and CD40L/IL-21R signals are crucial for the differentiation of human T-bet high CD21 low B cells.
The TNF family member protein BAFF/BLyS is essential for B cell survival and plays an important role in regulating class switch recombination as well the selection of autoreactive cells. In humans, increased concentrations soluble BAFF are found different pathological conditions, which may be diverse autoimmune diseases, malignancies, primary Ab deficiencies (PAD). Because mechanisms that regulate levels not understood, we newly developed a set mAbs against human to study parameters...