A5003710894- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Blood disorders and treatments
- Ocular Surface and Contact Lens
- T-cell and B-cell Immunology
- Salivary Gland Disorders and Functions
- Allergic Rhinitis and Sensitization
- Autoimmune and Inflammatory Disorders Research
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Gut microbiota and health
- Pneumonia and Respiratory Infections
- Chronic Lymphocytic Leukemia Research
- Skin Protection and Aging
- Immunotherapy and Immune Responses
- Adolescent and Pediatric Healthcare
- Congenital heart defects research
- Cystic Fibrosis Research Advances
- Immune responses and vaccinations
- CAR-T cell therapy research
- Platelet Disorders and Treatments
- Food Allergy and Anaphylaxis Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Lysosomal Storage Disorders Research
- Glaucoma and retinal disorders
Universidad de Antioquia
2015-2025
The University of Texas Medical Branch at Galveston
2025
Ocular Surface Center
2019-2023
Baylor College of Medicine
2019-2023
Colciencias
2015-2016
University College London
2012
The Royal Free Hospital
2012
National Center for Infectious Diseases
2005-2009
University of Würzburg
2005-2006
T cell–derived IFNγ and CD40L/IL-21R signals are crucial for the differentiation of human T-bet high CD21 low B cells.
Human natural killer (NK) cells can be subdivided in several subpopulations on the basis of relative expression adhesion molecule CD56 and activating receptor CD16. Whereas blood CD56brightCD16dim/- NK are classically viewed as immature precursors cytokine producers, larger CD56dimCD16bright subset is considered most cytotoxic one. In peripheral healthy donors, we noticed existence a population CD56dimCD16dim that was frequently higher number than CD56bright subsets even expanded occasional...
X-linked immunodeficiency with magnesium defect, EBV infection, and neoplasia (XMEN) disease are caused by deficiency of the transporter 1 (MAGT1) gene. We studied 23 patients XMEN, 8 whom were naive. observed lymphadenopathy (LAD), cytopenias, liver disease, cavum septum pellucidum (CSP), increased CD4-CD8-B220-TCRαβ+ T cells (αβDNTs), in addition to previously described features an inverted CD4/CD8 ratio, CD4+ lymphocytopenia, B cells, dysgammaglobulinemia, decreased expression natural...
Sjögren syndrome (SS) is an autoimmune inflammatory disorder characterized by secretory dysfunction in the eye and mouth; eye, this results tear film instability, reduced production, corneal barrier disruption. A growing number of studies show that homeostasis ocular surface impacted intestinal microbiome, several 16S sequencing have demonstrated dysbiosis microbiota SS patients. In study, we utilized metagenomic to perform a deeper analysis microbiome using stools collected from sex-...
Aging is a complex biological process in which many organs are pathologically affected. We previously reported that aged C57BL/6J had increased lacrimal gland (LG) lymphoid infiltrates suggest ectopic structures. However, these structures have not been fully investigated. Using mice of different ages, we analyzed the transcriptome murine LGs and characterized B T cell populations. Age-related changes LG include differentially expressed genes associated with activation, germinal center...
In February 2024, while conducting surveillance for novel respiratory viruses, we studied four beef cattle farms near Monterrey, Mexico. Nasal swabs were collected from sick and healthy along with 3 h aerosol samples. None of the samples had molecular evidence influenza A viruses. Three (8%) thirty-six nasal (33.3%) twelve bioaerosol specimens D virus. Five cow one sample on a single farm rodent coronavirus-like (RCoV), an alphacoronavirus. (60%) five RCoV-positive also D. Attempts to...
Epidemiological studies suggest that infections with helminths protect from the development of asthma. Supporting this view is our published finding infection Nippostrongylus brasiliensis decreased ovalbumin-induced Th2 responses in lung mice.To evaluate if N. excretory-secretory products also prevent asthma.Mice were immunized ovalbumin/alum intraperitoneally absence or presence helminthic and then challenged intranasally ovalbumin. Six days later, we analyzed mice developed lung.The...
Sjögren syndrome (SS) is an autoimmune condition that targets the salivary and lacrimal glands, with cardinal clinical signs of dry eye (keratoconjunctivitis sicca, KCS) mouth. The conjunctiva SS patients often infiltrated by immune cells participate in induction maintenance local inflammation. purpose this study was to investigate immune-related molecular pathways activated patients. Female (n=7) controls (n=19) completed a series oral, ocular surface exams. Symptom severity scores were...
Summary Background Allergen‐induced T‐helper type 2 (Th2) responses can be inhibited with Th1 directing vaccines. However, studies comparing the efficacy of different adjuvants have not been performed in detail. Objective For this reason we compare effects live Bacillus–Calmette–Guerin(BCG), heat‐killed (hk)‐BCG, CpG‐ODN (oligodeoxynucleotide) or PPD on development allergen‐induced Th2 mice. Methods Ovalbumin (OVA)‐specific allergic were induced C57BL/6 mice by two intraperitoneally (i.p.)...
<i>Background:</i> Recent clinical trials, epidemiological studies and animal experiments have suggested that probiotics may help suppress the development of allergic responses. <i>Objective:</i> To investigate whether application probiotic <i>Escherichia coli</i> strain Nissle 1917 (EcN) protects mice from developing ovalbumin (OVA)-specific T helper-2 responses in airways. <i>Methods:</i> OVA-specific Th2 were induced by 2 intraperitoneal...
Aged C57BL/6J (B6) mice have increased levels of cathepsin S, and aged S (Ctss-/-) knockout are resistant to age-related dry eye. This study investigated the effects inhibition on eye disease.
Dry eye disease (DED), one of the most prevalent conditions among elderly, is a chronic inflammatory disorder that disrupts tear film stability and causes ocular surface damage. Aged C57BL/6J mice spontaneously develop DED. Rapamycin potent immunosuppressant prolongs lifespan several species. Here, we compared effects daily instillation eyedrops containing rapamycin or empty micelles for three months on aged mice. Tear cytokine/chemokine profile showed pronounced increase in vascular...
Euphorbiaceae plants exhibit anti-inflammatory and immunomodulatory properties.We evaluated the activity of 14 extracts from seven on primary immune cell cultures healthy individuals. Peripheral blood mononuclear cells (PBMC) were exposed to w/o phytohaemagglutinin A or cycloheximide as agents that induce proliferation apoptosis in PBMC, respectively.We found five up Euphorbiaceae's had ability modulate at least one parameters this study. However, only latex Euphorbia cotinifolia tirucalli...