Musa Karakükçü
A5069928130- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Hemoglobinopathies and Related Disorders
- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Erythrocyte Function and Pathophysiology
- Blood Coagulation and Thrombosis Mechanisms
- Blood disorders and treatments
- Cytomegalovirus and herpesvirus research
- Lymphoma Diagnosis and Treatment
- Platelet Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Neonatal Health and Biochemistry
- Folate and B Vitamins Research
- Hemophilia Treatment and Research
- Autoimmune and Inflammatory Disorders Research
- Neuroblastoma Research and Treatments
- Acute Myeloid Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Mesenchymal stem cell research
- IL-33, ST2, and ILC Pathways
- Neutropenia and Cancer Infections
Erciyes University
2016-2025
Kayseri Eğitim ve Araştırma Hastanesi
2012-2025
Bozok Universitesi
2017-2024
Pediatric Oncology Group
2018-2019
Pediatrics and Genetics
2003-2013
Turkish Society of Hematology
2010
Palmetto Hematology Oncology
2006-2009
X-linked immunodeficiency with magnesium defect, EBV infection, and neoplasia (XMEN) disease are caused by deficiency of the transporter 1 (MAGT1) gene. We studied 23 patients XMEN, 8 whom were naive. observed lymphadenopathy (LAD), cytopenias, liver disease, cavum septum pellucidum (CSP), increased CD4-CD8-B220-TCRαβ+ T cells (αβDNTs), in addition to previously described features an inverted CD4/CD8 ratio, CD4+ lymphocytopenia, B cells, dysgammaglobulinemia, decreased expression natural...
Although autoimmunity and hyperinflammation secondary to recombination activating gene (RAG) deficiency have been associated with delayed diagnosis even death, our current understanding is limited primarily small case series.
BackgroundActivated phosphoinositide 3-kinase delta syndrome (APDS) is a combined immunodeficiency with heterogeneous phenotype considered reversible by allogeneic hematopoietic cell transplantation (HCT).ObjectivesThis study sought to characterize HCT outcomes in APDS.MethodsRetrospective data were collected on 57 patients APDS1/2 (median age, 13 years; range, 2-66 years) who underwent HCT.ResultsPre-HCT comorbidities such as lung, gastrointestinal, and liver pathology common, hematologic...
To examine the effect of carbamezapine and valproate on bone mineral density (BMD), IGF-I IGFBP-3 levels in children.
Patients with hypomorphic mutations in the RAG1 or RAG2 gene present either Omenn syndrome atypical combined immunodeficiency a wide phenotypic range. Hematopoietic stem cell transplantation (HSCT) is potentially curative, but data are scarce. We report on worldwide cohort of 60 patients RAG variants who underwent HSCT, 78% whom experienced infections (29% active at HSCT), 72% had autoimmunity, and 18% granulomas pretransplant. These complications frequently associated organ damage. Eight...
Background/Aims: Preimplantation genetic diagnosis (PGD) with human leukocyte antigen (HLA) typing represents a significant advancement in treating inherited hematological disorders, particularly thalassemia major.This technology enables the birth of healthy children who can serve as compatible stem cell donors for their affected siblings.Turkey is world leader both PGD+HLA and hematopoietic transplantation from savior siblings born through typing.Aims: This study investigated experiences...
Objective: B-cell Non-Hodgkin Lymphoma (B-NHL) is an aggressive malignancy in children requiring prompt multidisciplinary management. This retrospective cohort study aims to evaluate the clinical characteristics, treatment outcomes, and impact of rituximab (RTX) pediatric B-NHL patients. Methods: We retrospectively analyzed 62 patients treated at tertiary centers. Patient demographics, presentation, histopathological subtypes, disease stage, regimens, survival outcomes were assessed....
Aims: Infantile hemangioma (IH) is the most common benign vascular tumor in childhood. Diagnosis, treatment decisionmaking, and monitoring of are challenging. This study aims to investigate utilization platelet (PLT) indices as a marker follow-up IH treatment. Methods: The patients who were admitted followed up outpatient clinic Erciyes University Department Pediatric Hematology Oncology enrolled study. demographical data, results, PLT at certain time points analyzed retrospectively. PLT,...
Abstract Primary hemophagocytic lymphohistiocytosis (p-HLH) can be cured with allogeneic haematopoietic stem cell transplantation (allo-HSCT). It remains unclear whether HSCT outcomes are affected by the presence of different genetic mutations. We used data obtained from children who underwent allo-HSCT for HLH to examine effects mutations on outcomes. Data 153 paediatric patients in 18 centres were retrospectively evaluated. Patients divided into four groups: 1) PRF1 mutation ( n = 46), 2)...