Jenna Bergerson
A5079240199- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Blood disorders and treatments
- SARS-CoV-2 and COVID-19 Research
- Diabetes and associated disorders
- Chronic Lymphocytic Leukemia Research
- Adenosine and Purinergic Signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Viral Infections and Immunology Research
- Genetic factors in colorectal cancer
- interferon and immune responses
- Cytomegalovirus and herpesvirus research
- CAR-T cell therapy research
- RNA regulation and disease
- Complement system in diseases
- Genomics and Rare Diseases
- Parvovirus B19 Infection Studies
- Polyomavirus and related diseases
- COVID-19 Clinical Research Studies
- Platelet Disorders and Treatments
- Food Allergy and Anaphylaxis Research
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Immune responses and vaccinations
National Institute of Allergy and Infectious Diseases
2018-2025
National Institutes of Health
2018-2025
Immune Deficiency Foundation
2021-2024
Office of Extramural Research
2019-2022
Flinders Medical Centre
2022
University of Exeter
2022
Children's Hospital of Pittsburgh
2022
Organogenesis (United States)
2019
Lurie Children's Hospital
2016-2018
Northwestern University
2017-2018
The Human Phenotype Ontology (HPO)—a standardized vocabulary of phenotypic abnormalities associated with 7000+ diseases—is used by thousands researchers, clinicians, informaticians and electronic health record systems around the world. Its detailed descriptions clinical computable disease definitions have made HPO de facto standard for deep phenotyping in field rare disease. HPO's interoperability other ontologies has enabled it to be improve diagnostic accuracy incorporating model organism...
Roseomonas mucosa treatment in children with atopic dermatitis is associated clinical improvements and potentially lipid-mediated TNF signaling.
SARS-CoV-2 vaccination is recommended in patients with inborn errors of immunity (IEIs); however, little known about immunogenicity and safety these patients.
X-linked immunodeficiency with magnesium defect, EBV infection, and neoplasia (XMEN) disease are caused by deficiency of the transporter 1 (MAGT1) gene. We studied 23 patients XMEN, 8 whom were naive. observed lymphadenopathy (LAD), cytopenias, liver disease, cavum septum pellucidum (CSP), increased CD4-CD8-B220-TCRαβ+ T cells (αβDNTs), in addition to previously described features an inverted CD4/CD8 ratio, CD4+ lymphocytopenia, B cells, dysgammaglobulinemia, decreased expression natural...
Abstract The study of early T-cell development in humans is challenging because limited availability thymic samples and the limitations vitro differentiation assays. We used an artificial organoid (ATO) platform generated by aggregating a DLL4-expressing stromal cell line (MS5-hDLL4) with CD34+ cells isolated from bone marrow or mobilized peripheral blood to patients carrying hematopoietic intrinsic defects that cause lymphopenia. found AK2 deficiency associated decreased viability block...
The deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessively inherited disease that has undergone extensive phenotypic expansion since being first described in patients with fevers, recurrent strokes, livedo racemosa, and polyarteritis nodosa 2014. It now recognized may develop multisystem spans multiple medical subspecialties. Here, we describe the findings from a large single center longitudinal cohort 60 patients, broad presentation, as well highlight cohort’s experience...
Recombination activating genes ( RAGs ) are tightly regulated during lymphoid differentiation, and their mutations cause a spectrum of severe immunological disorders. Hematopoietic stem progenitor cell (HSPC) transplantation is the treatment choice but limited by donor availability toxicity. To overcome these issues, we developed gene editing strategies targeting corrective sequence into human RAG1 homology-directed repair (HDR) validated them tailored two-dimensional, three-dimensional, in...
Human recombination-activating gene (RAG) deficiency can manifest with distinct clinical and immunological phenotypes. By applying a multiomics approach to large group of RAG-mutated patients, we aimed at characterizing the immunopathology associated each phenotype. Although defective T B cell development is common all phenotypes, patients hypomorphic RAG variants generate cells signatures immune dysregulation produce autoantibodies broad range self-antigens, including type I interferons....
We describe a previously-unappreciated role for Bruton's tyrosine kinase (BTK) in fungal immune surveillance against aspergillosis, an unforeseen complication of BTK inhibitors (BTKi) used treating B-cell lymphoid malignancies. studied BTK-dependent responses neutrophils from diverse populations, including healthy donors, BTKi-treated patients, and X-linked agammaglobulinemia patients. Upon exposure, was activated human TLR2-, Dectin-1-, FcγR-dependent manner, triggering the oxidative burst....
Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer. Of the patients who develop MCC annually, only 4% are younger than 50 years.
Patients with the monogenic immune dysregulatory syndrome autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), which is caused by loss-of-function mutations in regulator ( AIRE ) gene, uniformly carry neutralizing autoantibodies directed against type-I interferons (IFNs) and many develop pneumonitis, both of place them at high risk for life-threatening COVID-19 pneumonia. Bamlanivimab etesevimab are monoclonal antibodies (mAbs) that target SARS-CoV-2 spike protein block...
Summary Background Non‐cirrhotic portal hypertension (NCPH) is a spectrum of liver diseases, including porto‐sinusoidal vascular disorder, with (PH) in the absence cirrhosis. The natural history and diagnostic approach to NCPH are not well understood. Aim We aimed evaluate disease progression outcomes NCPH. Methods Patients or at risk for were enrolled single centre prospective study; two groups formed based on presence specific features PH, such as varices, collaterals, hypertensive...