A5042589344- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Pancreatitis Pathology and Treatment
- Liver Diseases and Immunity
- Organ Transplantation Techniques and Outcomes
- Diabetes Management and Research
- Renal Transplantation Outcomes and Treatments
- Histone Deacetylase Inhibitors Research
- Obesity, Physical Activity, Diet
- Peptidase Inhibition and Analysis
- Cancer-related cognitive impairment studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Porphyrin Metabolism and Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Long-Term Effects of COVID-19
- Telemedicine and Telehealth Implementation
- Hepatitis Viruses Studies and Epidemiology
- Diabetes Management and Education
- Protease and Inhibitor Mechanisms
- Methemoglobinemia and Tumor Lysis Syndrome
- Esophageal Cancer Research and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Diabetes and associated disorders
- Pulmonary Hypertension Research and Treatments
- Abdominal vascular conditions and treatments
Penn State Milton S. Hershey Medical Center
2021-2024
Pennsylvania State University
2021-2024
University Hospital Bonn
2023
University of Pittsburgh Medical Center
2016
Abstract Background and Aims NASH is a common disease associated with increased rates of thromboembolism (TE). Although exercise training can lessen thrombotic risk in patients vascular disease, whether similar findings are observed open for study. Approach Results We conducted 20‐week randomized controlled clinical trial involving biopsy‐confirmed NASH. Patients were randomly assigned (2:1 ratio) to receive either an program or standard care. The primary endpoint was change plasminogen...
Abstract Background and Aims Exercise training is recommended for all patients with metabolic dysfunction‐associated steatotic liver disease may reverse fibrosis. Whether exercise improves fibrosis without body weight loss remains controversial. We further investigated this relationship using serum biomarkers of fibroinflammation in a post hoc analysis an trial where did not lose significant weight. Methods In the NASHFit trial, steatohepatitis were randomized to receive either...
Summary Background Non‐cirrhotic portal hypertension (NCPH) is a spectrum of liver diseases, including porto‐sinusoidal vascular disorder, with (PH) in the absence cirrhosis. The natural history and diagnostic approach to NCPH are not well understood. Aim We aimed evaluate disease progression outcomes NCPH. Methods Patients or at risk for were enrolled single centre prospective study; two groups formed based on presence specific features PH, such as varices, collaterals, hypertensive...
This JAMA Patient Page explains the causes, symptoms, diagnosis, and treatment of spontaneous bacterial peritonitis, an infection fluid (ascites) that accumulates in abdomen liver disease other conditions.
Background Most patients with nonalcoholic fatty liver disease (NAFLD) are physically inactive despite the well-known benefits of physical activity. Telehealth offers promise as a novel way to deliver an exercise training program and increase However, feasibility, safety, efficacy telehealth-based programs is unknown in NAFLD. Objective The aim this study was determine feasibility directly supervised delivered exclusively telehealth steatohepatitis (NASH), progressive form Methods In...
Significantly worse survival has been reported in patients with hepatopulmonary syndrome (HPS) and partial pressure of arterial oxygen (PaO2) <45 mmHg undergoing liver transplantation. Long-term pre- post-transplant outcomes based on degree hypoxaemia were re-examined.A retrospective analysis 1,152 HPS candidates listed an approved model for end-stage disease (MELD) exception was performed. A Fine Gray competing risks utilised to evaluate pre-transplant PaO2 thresholds <45, 45 <60, ≥60 mmHg....
Potential conflict of interest: Nothing to report. SEE ARTICLES ON PAGE 502 and 504 During the past decade, major advancements in development mobile applications telehealth monitoring systems have assisted health care professionals diagnosis management chronic diseases. When effectively used, can lead higher quality better patient‐reported outcomes.(1) Mobile also improve patient self‐management metabolic disease.(2) Despite these known benefits other diseases, been slow be adopted standard...
ABSTRACT Porphyria caused by inherited disorders in heme biosynthesis can lead to accumulation of porphyrins various organs. Liver involvement due porphyria mostly results cholestasis leading liver cirrhosis or hepatocellular carcinoma. Congenital erythropoietic (CEP), a rare deficiency uroporphyrinogen III synthase, cutaneous manifestations. There are reports including varying degree fibrosis patients with CEP. We report unique case patient CEP who developed porto-sinusoidal vascular...
Hintergrund: Bei pathologischen Prozessen insbesondere entzündlicher und tumoröser Genese findet sich eine verstärkte Expression, Sekretion Aktivierung von Matrix-Metalloproteinasen (MMPs). In den vergangenen Jahren wurden in der eigenen Arbeitsgruppe radioaktiv markierte MMP-Inhibitoren synthetisiert (1) erfolgreich präklinisch evaluiert (2). einem translationalen Ansatz zeigen wir hier weltweit erstmals Enzyminhibitor-basierte PET-Bildgebung aktiven MMPs beim Menschen.
Aims Interval cancers after initial cancer negative upper GI endoscopy are not rare (Alexandre et al.). Here, we have analyzed the primary assessment of esophageal early neoplastic lesions which were then sent for endoscopic treatment in a tertiary referral center Germany.
Introduction: Prostate brachytherapy with radiation is an effective treatment for localized prostate cancer. While generally well tolerated, radiation-associated proctopathy resultant lower gastrointestinal (GI) bleeding a common complication of this treatment. Rarely, can result in rectoprostatic fistulae. There no standard endoscopic GI from complication. Increasingly, hemostatic powders are used as “bail-out” or temporizing measure to control when the source not amenable other...
Introduction: Hepatic amyloidosis can present as primary or, more commonly, secondary usually in the older population. Here, we a rare case of hepatic previously, young and healthy male. Case Description/Methods: A 37 year-old male presented an outside hospital transfer with 1-week history abdominal pain hematochezia 6-month fatigue, weight loss, ecchymosis, lower extremity edema. Physical exam demonstrated hepatosplenomegaly, distension ascites. Labs noted platelet count 465K/uL, white...
<sec> <title>BACKGROUND</title> Most patients with nonalcoholic fatty liver disease (NAFLD) are physically inactive despite the well-known benefits of physical activity. Telehealth offers promise as a novel way to deliver an exercise training program and increase However, feasibility, safety, efficacy telehealth-based programs is unknown in NAFLD. </sec> <title>OBJECTIVE</title> The aim this study was determine feasibility directly supervised delivered exclusively telehealth steatohepatitis...