Réda Djidjik
A5057925637- Immunodeficiency and Autoimmune Disorders
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- COVID-19 Clinical Research Studies
- Blood disorders and treatments
- Long-Term Effects of COVID-19
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Systemic Sclerosis and Related Diseases
- Multiple Myeloma Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- Asthma and respiratory diseases
- Toxin Mechanisms and Immunotoxins
- Cystic Fibrosis Research Advances
- Chronic Lymphocytic Leukemia Research
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Parvovirus B19 Infection Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Autoimmune Bullous Skin Diseases
- Child Nutrition and Feeding Issues
- T-cell and B-cell Immunology
- Spondyloarthritis Studies and Treatments
- Galectins and Cancer Biology
University of Algiers Benyoucef Benkhedda
2016-2025
Université des Sciences de la Santé
2025
Centre Hospitalo-Universitaire Bab El Oued
2007-2024
University of Algiers 3
2016-2024
Centre Hospitalier Universitaire Hassan II
2020-2021
Hôpital Saint-Louis
2014
Inserm
2014
Biologie Labor
2013-2014
Yahoo (United Kingdom)
2013
Human recombination-activating gene (RAG) deficiency can manifest with distinct clinical and immunological phenotypes. By applying a multiomics approach to large group of RAG-mutated patients, we aimed at characterizing the immunopathology associated each phenotype. Although defective T B cell development is common all phenotypes, patients hypomorphic RAG variants generate cells signatures immune dysregulation produce autoantibodies broad range self-antigens, including type I interferons....
Inborn errors of immunity (IEIs) are a heterogeneous group genetic defects immunity, which cause high rates morbidity and mortality mainly among children due to infectious non-infectious complications. The IEI burden has been critically underestimated in countries from middle- low-income regions the majority patients with these lack molecular diagnosis.We analyzed clinical, immunologic, data 22 Middle East North Africa (MENA) region. was collected national registries diverse databases such...
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of B cell tolerance to self antigens resulting in the production a wide variety auto antibodies. The objective this study was assessment serum free light chains (FLC) assay patients with SLE. In study, 156 (142 women and 14 men, mean age 35.6 years) 60 healthy subjects (55 5 36.4 were included. kappa (κ) lambda (λ) FLC measured turbidimetry method. analysis our results showed that rates κ λ significantly higher...
OBJECTIVE: 5-Fluorouracil is a widely used antimetabolite in oncology but can be toxic, particularly patients with dihydropyrimidine dehydrogenase deficiency. A plasma uracil level exceeding 16 ng/mL and metabolic ratio (dihydrouracil/uracil) below 6 are indicators of DPD This study compares different screening methods for MATERIALS AND METHODS: One hundred eighty-eight Algerian colorectal cancer treated were screened deficiency using DPYD genotyping, phenotyping levels ratio,...
Monogenic immune dysregulation diseases (MIDD) are caused by defective immunotolerance. This study was designed to increase knowledge on the prevalence and spectrum of MIDDs, genetic patterns, outcomes in Middle East North Africa (MENA). MIDD patients from 11 MENA countries (Iran, Turkey, Kuwait, Oman, Algeria, Egypt, United Arab Emirates, Tunisia, Jordan, Qatar, Azerbaijan) were retrospectively evaluated. 343 (58% males 42% female) at a median (IQR) age 101 (42-192) months enrolled. The...
Abstract The immune system plays a crucial role in the response against severe acute respiratory syndrome coronavirus 2 with significant differences among patients. study investigated relationships between lymphocyte subsets, cytokines, and disease outcomes patients 2019 (COVID-19). measurements of peripheral blood lymphocytes subsets cytokine levels were performed by flow cytometry for 57 COVID-19 Patients categorized into two groups according to severity (nonsevere vs. severe). Total...
Presenting processed antigens to CD4+ lymphocytes during the immune response involves major histocompatibility complex class II molecules. MHC genes transcription is regulated by four factors: CIITA, RFXANK, RFX5 and RFXAP. Defects in these factors result expression deficiency, a primary combined immunodeficiency frequent North Africa. Autosomal recessive mutations RFXANK gene have been reported as being principal defect found African patients with this disorder. In paper, we describe...
Multiple assays have been developed for the characterization of functional activation SARS-CoV-2 specific T-cells. This study was conducted to assess post-vaccination and post-infection T cell response, as detected by QuantiFERON-SARS-CoV-2 assay using combination three antigens (Ag1, Ag2 Ag3). An amount 75 participants with different infection vaccination backgrounds were recruited evaluation humoral cellular immune responses. elevated IFN-γ response in at least one Ag tube observed 69.2%...
Methotrexate (MTX) is the most used drug in rheumatoid arthritis (RA) treatment. However, it shows variability clinical response, which explained by an association with genetic polymorphisms. This study aimed to elucidate role of two gene polymorphism C677T and A1298C methylenetetrahydrofolate reductase (MTHFR) response MTX Algerian RA patients. Study included 54 early patient treated for one year. efficiency toxicity were evaluated at 6 12 months respectively polymorphisms genotyped. No was...
Abstract Introduction Rheumatoid arthritis ( RA ) is a chronic, systemic, inflammatory and multifactorial disease. Genetic predisposition seems to play an important role. The aim of this study explore the relationship between human leukocyte antigen HLA )‐ DRB 1 alleles susceptibility, clinical biological features in Algerian patient population. Methods Using polymerase chain reaction – sequence specific primers SSP ), 134 patients 132 healthy controls were genotyped for ‐ 1*04 subtypes....
To address inborn errors of immunity (IEI) which were underdiagnosed in resource-limited regions, our centre developed and offered free genetic testing for the most common IEI by Sanger sequencing (SS) since 2001. With establishment The Asian Primary Immunodeficiency (APID) Network 2009, awareness definitive diagnosis further improved with collaboration among centres caring patients from East Southeast Asia. We also started to use whole exome (WES) undiagnosed cases extended South Asia...
Aim: To describe the autoantibody profile in a cohort of Algerian patients with systemic sclerosis (SSc) and to determine clinical associations between SSc-related autoantibodies, disease subtypes specific features.Methods: Consecutive SSc were included present study.In addition characterization, all subjects underwent testing using indirect immunofluorescence, immunoenzymatic, line immunoblot assays.Results: A total 150 this study, 103 (68.7%) had limited cutaneous (lcSSc), 42 (28%) diffuse...