A5076016494- Mycobacterium research and diagnosis
- Antibiotic Resistance in Bacteria
- Hepatitis C virus research
- Infectious Diseases and Mycology
- Tuberculosis Research and Epidemiology
- Hepatitis B Virus Studies
- Fungal Infections and Studies
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- COVID-19 Clinical Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Antimicrobial Resistance in Staphylococcus
- Hepatitis Viruses Studies and Epidemiology
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Immunodeficiency and Autoimmune Disorders
- Antibiotic Use and Resistance
- Antifungal resistance and susceptibility
- Infectious Diseases and Tuberculosis
- Viral gastroenteritis research and epidemiology
- Antibiotics Pharmacokinetics and Efficacy
- Vibrio bacteria research studies
- Bacterial Identification and Susceptibility Testing
- HIV-related health complications and treatments
- Urinary Tract Infections Management
National Taiwan University Hospital
2016-2025
National Institute of Allergy and Infectious Diseases
2021-2025
National Institutes of Health
2021-2025
National Yang Ming Chiao Tung University
2020-2022
National Taiwan University
2011-2022
Engineering Associates (United States)
2018
Gilead Sciences (Germany)
2017
Memorial Hospital of South Bend
2012-2014
Cheng Hsin General Hospital
2014
Far Eastern Memorial Hospital
2011-2013
Abstract Background Risk factors and outcomes in hematological patients who acquire invasive fungal sinusitis (IFS) are infrequently reported the modern medical era. Method A retrospective study of hospitalized with disease was conducted at National Taiwan University Hospital between January 1995 December 2009. Results Clinical characteristics their associated radiographic microbiological findings were analyzed. Forty-six IFS 64 chronic non-invasive enrolled as comparsion. developed more...
Objectives: Since few therapeutic options exist for extensively drug resistant Acinetobacter baumannii, an emerging threat in ICUs worldwide, and comparative prospective studies of colistin-based combination therapies are lacking, our objective was to compare the outcomes patients with drug-resistant A. baumannii bacteremia, treated colistin-carbapenem colistin-tigecycline combinations. Design: Prospective, observational, multicenter study. Setting, Patients, Interventions: Adults bacteremia...
Autoantibodies against interleukin-12 (anti-interleukin-12) are often identified in patients with thymoma, but opportunistic infections develop only some of these patients. Interleukin-12 (with subunits p40 and p35) shares a common subunit interleukin-23 (subunits p19). In patient disseminated
Human recombination-activating gene (RAG) deficiency can manifest with distinct clinical and immunological phenotypes. By applying a multiomics approach to large group of RAG-mutated patients, we aimed at characterizing the immunopathology associated each phenotype. Although defective T B cell development is common all phenotypes, patients hypomorphic RAG variants generate cells signatures immune dysregulation produce autoantibodies broad range self-antigens, including type I interferons....
Sepsis-related mortality has been found increased in RAG-1 knockout mice. However, patients admitted to medical intensive care units, it is unknown whether severe lymphocyte depletion at admission associated with interleukin (IL)-7 and IL-15 levels circulation, mortality. We prospectively enrolled 92 who were units for sepsis or septic shock. At admission, 24 (26.1%) had lymphopenia, defined as counts of less than 0.5 × 10(3)/μL. Severe lymphopenia was significantly higher plasma tumor...
The Premier Clostridium difficile toxin A enzyme immunoassay (PTA EIA) (Meridian Diagnostics, Inc., Cincinnati, Ohio) for rapid diagnosis of antibiotic-associated colitis (AAC) was evaluated in a multicenter study. Stool samples from 421 patients suspected having AAC were tested by the PTA EIA and B three tissue culture assays (TCA) employing WI-38 cells (New England Deaconess Hospital) conventional tubes or foreskin fibroblasts (Children's Vero (Beth Israel microwells. plates examined at 24...
Background Perianal infection is a common problem for patients with acute leukemia. However, neutropenia and bleeding tendency are relatively contraindicated to surgical intervention. The epidemiology, microbiology, clinical manifestations outcomes of perianal in leukemic also rarely discussed. Method medical records 1102 adult leukemia at tertiary center Taiwan between 2001 2010 were retrospectively reviewed analyzed. Result prevalence was 6.7% (74 1102) Twenty-three (31%) the 74 had...
CNS infections caused by non-tuberculous mycobacteria (NTM) are rare and only three cases of due to Mycobacterium abscessus complex have been reported.We searched the Mycobacteriology Database National Taiwan University Hospital identified patients with NTM.A total 15 patients, namely 4 HIV-seropositive 11 HIV-seronegative NTM were during 2000-10. All had disseminated avium infections. Among M. in 8 2 kansasii 1 patient. six preserved isolates confirmed be massiliense erm(41) PCR 23S rRNA...
Clinical characteristics and outcomes of intracranial hemorrhage (ICH) among adult patients with various hematological malignancies are limited. A total 2,574 diagnosed admitted to a single university hospital were enrolled into this study between 2001 2010. The clinical characteristics, image reports retrospectively analyzed. 72 (48 men 24 women) median age 56 (range 18 86) had an ICH. overall ICH incidence was 2.8% malignancies. higher in acute myeloid leukemia (AML) than other (6.3% vs...
ABSTRACT We describe six patients with hospital-acquired bacteremia caused by Methylobacterium species, including M. radiotolerans ( n = 2), thiocyanatum aminovorans 1), and lusitanum which were confirmed to species level 16S rRNA gene sequence analysis. Among these patients, five had catheter-related all favorable outcomes.
BackgroundTo identify novel factors associated with the survival of septic adults receiving extracorporeal membrane oxygenation (ECMO) to improve patient selection and outcomes.MethodsCases were identified from our ECMO registry 2001 2011 if they ≥16 years received for life-threatening sepsis.ResultsA total 151 a median (25th-75th percentile) age 51 (37-63) analyzed. Pneumonia (50%), myocarditis (20%), primary bloodstream infections (15%) main types infection, caused by predominantly...
Patients admitted to intensive care units (ICUs) are at high risk for central line-associated bloodstream infections (CLABSIs). Bundle has been documented reduce CLABSI rates in Western countries, however, few reports were from Asian countries and the differences epidemiology or outcomes of critically-ill patients with CLABSIs after implementation bundle remain unknown. We aimed evaluate incidence, microbiological characteristics, factors associated mortality care.Prospective surveillance...
Binding levels and neutralization activity of anti-type 1 interferon autoantibodies peaked during acute coronavirus disease 2019 markedly decreased thereafter. Most patients maintained some ability to neutralize type into convalescence despite lower binding immunoglobulin G. Identifying these in healthy individuals before the development critical viral may be challenging.
Abstract Background An unprecedented outbreak of acute hepatitis A has occurred among MSM in Taiwan since June 2015. We aimed to describe the seroepidemiology HAV infection and investigate relationship between vaccination incidence HIV‐positive patients at largest designated hospital for HIV care during outbreak. Methods Between 2012 2016, serostatus, history clinical characteristics were retrospectively reviewed. case‐control study was performed identify factors associated with A. The...
Infections caused by the difficult-to-treat bacterium Mycobacterium abscessus are increasing in frequency. Rifabutin, contrast to rifampin, appears be active vitro against M. abscessus, especially clarithromycin-resistant strains. However, explorations for potential synergy between rifabutin and available antimicrobials currently limited. In synergism 10 was evaluated 31 mycobacterial strains checkerboard method. The fractional inhibitory concentration index (FICI) calculated each...
Anti GM-CSF autoantibodies (aAb) have been related to acquired pulmonary alveolar proteinosis (PAP) and described in cases of severe infections such as cryptococcosis nocardiosis previously healthy subjects. Whether there are different anti-GM-CSF corresponding these phenotypes is unclear. Therefore, we examined determine whether amount or neutralizing activity could distinguish between groups. Plasma samples gathered the National Institute Health from patients with anti aAb either PAP (n =...
Abstract Background Mycobacterium abscessus is notoriously difficult to treat. Current guidelines suggest a 14-day long incubation period and/or sequencing of erm41 detect inducible macrolide resistance when treating pulmonary disease. However, the lengthy inconvenient, and genotyping not routinely available nor correlated with treatment outcomes in extrapulmonary infections. We aimed assess whether more than two-fold change minimum inhibitory concentrations (MICs) at D7 can reliably predict...
Neutralizing anti-interferon (IFN)-α autoantibodies can lead to immune dysregulation, potentially resulting in critical coronavirus disease 2019 (COVID-19). We report a case presenting with severe COVID-19 who was subsequently diagnosed have thymoma and neutralizing anti-IFN-α autoantibodies.