Elif Karakoç-Aydıner
A5028591438- Immunodeficiency and Autoimmune Disorders
- Blood disorders and treatments
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Platelet Disorders and Treatments
- Asthma and respiratory diseases
- Diabetes and associated disorders
- Dermatology and Skin Diseases
- Cytomegalovirus and herpesvirus research
- Chronic Lymphocytic Leukemia Research
- Cystic Fibrosis Research Advances
- RNA modifications and cancer
- Eosinophilic Esophagitis
- Pediatric health and respiratory diseases
- Blood groups and transfusion
- Digestive system and related health
- Neurogenetic and Muscular Disorders Research
- DNA Repair Mechanisms
- Parvovirus B19 Infection Studies
- Urticaria and Related Conditions
- Complement system in diseases
- Renal Diseases and Glomerulopathies
- IL-33, ST2, and ILC Pathways
Marmara University
2016-2025
Jeffrey Modell Foundation
2025
Fakultet za Poslovni Menadžment u Baru
2024
ENT and Allergy
2020-2021
National Academy of Medicine
2021
National Human Genome Research Institute
2021
GC Corporation (Japan)
2021
Universal Scientific Education and Research Network
2020
Pulmonary and Critical Care Associates
2020
Ümraniye Eğitim ve Araştırma Hastanesi
2018
Trafficking from bedside to bench Typically in translational research, a discovery cell or molecular biology is later exploited improve patient care. Occasionally, information flows the opposite direction. Lo et al. found that patients with an autoimmune disorder caused by deficiency of protein called LRBA responded dramatically drug abatacept (see Perspective Sansom). Abatacept contains segment potent inhibitory immune receptor, CTLA4. Experiments prompted this observation revealed...
There is uncertainty about the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in individuals with rare inborn errors immunity (IEI), a population at risk developing disease 2019. This relevant not only for these patients but also general population, because studies IEIs can unveil key requirements host defense.
<h3>Background</h3> Immunodysregulation polyendocrinopathy enteropathy x-linked (IPEX) syndrome is a monogenic autoimmune disease caused by <i>FOXP3</i> mutations. Because it rare disease, the natural history and response to treatments, including allogeneic hematopoietic stem cell transplantation (HSCT) immunosuppression (IS), have not been thoroughly examined. <h3>Objective</h3> This analysis sought evaluate onset, progression, long-term outcome of 2 main treatments in IPEX survivors....
Studies of monogenic gastrointestinal diseases have revealed molecular pathways critical to gut homeostasis and enabled the development targeted therapies.
Activated Phosphoinositide 3-kinase (PI3K) δ Syndrome (APDS), caused by autosomal dominant mutations in PIK3CD (APDS1) or PIK3R1 (APDS2), is a heterogeneous primary immunodeficiency. While initial cohort-descriptions summarized the spectrum of clinical and immunological manifestations, questions about long-term disease evolution response to therapy remain. The prospective European Society for Immunodeficiencies (ESID)-APDS registry aims characterize course, identify outcome predictors...
BackgroundRecent findings strongly support hematopoietic stem cell transplantation (HSCT) in patients with severe presentation of LPS-responsive beige-like anchor protein (LRBA) deficiency, but long-term follow-up and survival data beyond previous patient reports or meta-reviews are scarce for those who do not receive a transplant.ObjectiveThis international retrospective study was conducted to elucidate the longitudinal clinical course LRBA deficiency transplant.MethodWe assessed disease...
Human recombination-activating gene (RAG) deficiency can manifest with distinct clinical and immunological phenotypes. By applying a multiomics approach to large group of RAG-mutated patients, we aimed at characterizing the immunopathology associated each phenotype. Although defective T B cell development is common all phenotypes, patients hypomorphic RAG variants generate cells signatures immune dysregulation produce autoantibodies broad range self-antigens, including type I interferons....
Background We aimed to investigate the efficacy, safety, and T regulatory cell response of vitamin D as an adjunct allergen-specific immunotherapy (IT). Methods Fifty children with asthma receiving pharmacotherapy were randomized into three groups as: subcutaneous IT (SCIT) along supplementation (650 U/day; n: 17), SCIT alone (n: 15), 18). All patients evaluated at baseline, 6th 12th months for scorings symptoms medication, skin prick testing, total IgE, specific Der p 1-specific IgG4. In...
Although autoimmunity and hyperinflammation secondary to recombination activating gene (RAG) deficiency have been associated with delayed diagnosis even death, our current understanding is limited primarily small case series.
Inborn errors of immunity (IEIs) are a heterogeneous group genetic defects immunity, which cause high rates morbidity and mortality mainly among children due to infectious non-infectious complications. The IEI burden has been critically underestimated in countries from middle- low-income regions the majority patients with these lack molecular diagnosis.We analyzed clinical, immunologic, data 22 Middle East North Africa (MENA) region. was collected national registries diverse databases such...