Yazmín Espinosa
A5050660656- Kawasaki Disease and Coronary Complications
- COVID-19 Clinical Research Studies
- Systemic Lupus Erythematosus Research
- Mechanical Circulatory Support Devices
- Wound Healing and Treatments
- Autoimmune and Inflammatory Disorders Research
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Cytomegalovirus and herpesvirus research
- Pressure Ulcer Prevention and Management
- Parvovirus B19 Infection Studies
- Congenital Diaphragmatic Hernia Studies
- Phagocytosis and Immune Regulation
- Immunodeficiency and Autoimmune Disorders
- Vasculitis and related conditions
- Diabetic Foot Ulcer Assessment and Management
- Neonatal Respiratory Health Research
- Macrophage Migration Inhibitory Factor
Hospital Roberto del Rio
2017-2025
Universidad del Desarrollo
2020
Clínica Alemana
2020
University of Chile
2017
University of the Andes
1999
There is uncertainty about the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in individuals with rare inborn errors immunity (IEI), a population at risk developing disease 2019. This relevant not only for these patients but also general population, because studies IEIs can unveil key requirements host defense.
In a subset of children and adolescents, SARS-CoV-2 infection induces severe acute hyperinflammatory shock1 termed multisystem inflammatory syndrome in (MIS-C) at four to eight weeks after infection. MIS-C is characterized by specific T cell expansion2 systemic hyperinflammation3. The pathogenesis remains largely unknown. Here we show that impaired reactivation virus-reactive memory cells, which depends on increased serum levels the cytokine TGFβ resembling those occur during COVID-19 (refs....
The antibody profile against autoantigens previously associated with autoimmune diseases and other human proteins in patients COVID-19 or multisystem inflammatory syndrome children (MIS-C) remains poorly defined. Here we show that 30% of adults had autoantibodies the lung antigen KCNRG, 34% antibodies to SLE-associated Smith-D3 protein. Children rarely autoantibodies; one 59 GAD65 acute onset insulin-dependent diabetes. While SLE/Sjögren’s (Ro52, Ro60, La) and/or gastritis (gastric ATPase)...
The clinical impact of viral factors (types and loads) during respiratory syncytial virus (RSV) infection is still controversial, especially regarding newly described genotypes. In this study, infants with RSV bronchiolitis were recruited to describe the association these severity infection. antigenic types, genotypes, loads determined from hospitalized patients at Hospital Roberto del Río, Santiago, Chile. Cases characterized by demographic information, including days lower symptoms...
Abstract Pediatric COVID-19 (pCOVID-19) is rarely severe, however a minority of SARS-CoV-2-infected children may develop MIS-C, multisystem inflammatory syndrome with significant morbidity. In this longitudinal multi-institutional study, we used multi-omics to identify novel time- and treatment-related immunopathological signatures in (n=105) MIS-C (n=76). pCOVID-19 was characterized by enhanced type I IFN responses, II IFN- NF-κB dependent matrisome activation, increased levels Spike...
Abstract The autoantibody profile associated with known autoimmune diseases in patients COVID-19 or multisystem inflammatory syndrome children (MIS-C) remains poorly defined. Here we show that adults had a moderate prevalence of autoantibodies against the lung antigen KCNRG, and SLE-associated Smith autoantigen. Children rarely autoantibodies; one 59 GAD65 acute insulin-dependent diabetes. While SLE/Sjögren’s (Ro52, Ro60, La) and/or gastritis (gastric ATPase) were detected 74% (40/54) MIS-C...