Scott B. Snapper
A5052060864- Inflammatory Bowel Disease
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Microscopic Colitis
- IL-33, ST2, and ILC Pathways
- Helicobacter pylori-related gastroenterology studies
- Cell Adhesion Molecules Research
- T-cell and B-cell Immunology
- Cellular Mechanics and Interactions
- Eosinophilic Esophagitis
- Immune Response and Inflammation
- Gut microbiota and health
- Single-cell and spatial transcriptomics
- Mycobacterium research and diagnosis
- Digestive system and related health
- Tuberculosis Research and Epidemiology
- Celiac Disease Research and Management
- Escherichia coli research studies
- Infant Nutrition and Health
- Immune cells in cancer
- Immune responses and vaccinations
- Bacterial Genetics and Biotechnology
- Inflammasome and immune disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Blood disorders and treatments
Boston Children's Hospital
2016-2025
Boston Children's Museum
2012-2025
Brigham and Women's Hospital
2015-2024
Harvard University
2015-2024
Bristol-Myers Squibb (Switzerland)
2024
Entasis Therapeutics (United States)
2024
AbbVie (United States)
2024
Pfizer (United States)
2024
Janssen (Belgium)
2024
Aurobindo Pharma (United States)
2024
The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis result from alterations in intestinal microbes the immune system. However, precise dysfunctions of microbial metabolism gastrointestinal microbiome during IBD remain unclear. We analyzed microbiota biopsies stool samples 231 healthy subjects by 16S gene pyrosequencing followed up a subset using shotgun metagenomics. Gene pathway composition were assessed, based on data phylogenetically-related reference genomes,...
There is pressing urgency to understand the pathogenesis of severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2), which causes disease COVID-19. SARS-CoV-2 spike (S) protein binds angiotensin-converting enzyme (ACE2), and in concert with host proteases, principally transmembrane serine protease (TMPRSS2), promotes cellular entry. The cell subsets targeted by tissues factors that regulate ACE2 expression remain unknown. Here, we leverage human, non-human primate, mouse...
We performed genetic-linkage analysis and candidate-gene sequencing on samples from two unrelated consanguineous families with children who were affected by early-onset inflammatory bowel disease. screened six additional patients colitis for mutations in candidate genes carried out functional assays patients' peripheral-blood mononuclear cells. an allogeneic hematopoietic stem-cell transplantation one patient.
Summary Recent development of vectors and methodologies to introduce recombinant DNA into members the genus Mycobacterium has provided new approaches for investigating these important bacteria. While most pathogenic mycobacteria are slow‐growing, smegmatis is a fast‐growing, non‐pathogenic species that been used many years as host mycobacteriophage propagation and, recently, introduction DNA. Its use cloning analysis mycobacterial genes limited by its inability be efficiently transformed...
An interleukin controls a metabolic switch in macrophages that inhibits signaling pathway, thereby suppressing intestinal inflammation.
Gut microbes make T cells keep the peace Our guts harbor trillions of microbial inhabitants, some which regulate types immune that are present in gut. For instance, Clostridium species bacteria induce a type cell promotes tolerance between host and its contents. Ohnmacht et al. Sefik characterized population gut regulatory mice, required microbiota to survive. Multiple bacterial could transcription factor–expressing helped maintain homeostasis. Mice engineered lack these factors exhibited...
Phosphoinositide 3-kinase (PI3K) activation has been implicated in many cellular responses, including fibroblast growth, transformation, survival, and chemotaxis. Although PI3K is activated by several agents that stimulate T B cells, the role of lymphocyte function not clear. The mouse gene encoding adapter subunit p85α its splice variants p55α p50α was disrupted. Most p85α-p55α-p50α −/− mice die within days after birth. Lymphocyte development studied with use RAG2-deficient blastocyst...
Interleukin-10 (IL-10) signaling genes are attractive inflammatory bowel disease (IBD) candidate as IL-10 restricts intestinal inflammation, polymorphisms have been associated with IBD in genome-wide association studies, and mutations receptor (IL-10R) reported immunodeficient children severe infantile-onset IBD. Our objective was to determine if IL-10R were early-onset (EO-IBD) very-early-onset (VEO-IBD).Candidate-gene analysis of IL10RA IL10RB performed after initial sequencing an...