Vassilios Lougaris
A5048891191- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Blood disorders and treatments
- Platelet Disorders and Treatments
- Cystic Fibrosis Research Advances
- Diabetes and associated disorders
- NF-κB Signaling Pathways
- Blood groups and transfusion
- Immune Response and Inflammation
- PI3K/AKT/mTOR signaling in cancer
- Cytomegalovirus and herpesvirus research
- Congenital Ear and Nasal Anomalies
- Gastrointestinal disorders and treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chemokine receptors and signaling
- Parvovirus B19 Infection Studies
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Celiac Disease Research and Management
- Lymphoma Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- Asthma and respiratory diseases
Brescia University
2002-2024
University of Brescia
2015-2024
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2015-2024
Federico II University Hospital
2024
Weatherford College
2022
Institute for Molecular Medicine
2022
University of South Florida
2022
Flinders Medical Centre
2022
Flinders University
2022
Hospital Sant Joan de Déu Barcelona
2021
There is uncertainty about the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in individuals with rare inborn errors immunity (IEI), a population at risk developing disease 2019. This relevant not only for these patients but also general population, because studies IEIs can unveil key requirements host defense.
Activated phosphoinositide 3-kinase δ syndrome (APDS) 2 (p110δ-activating mutations causing senescent T cells, lymphadenopathy, and immunodeficiency [PASLI]-R1), a recently described primary immunodeficiency, results from autosomal dominant in PIK3R1, the gene encoding regulatory subunit (p85α, p55α, p50α) of class IA 3-kinases.We sought to review clinical, immunologic, histopathologic phenotypes APDS2 genetically defined international patient cohort.The medical biological records 36...
Abstract Activated phosphoinositide 3-kinase delta (PI3Kδ) syndrome (APDS) is an inborn error of immunity with clinical manifestations including infections, lymphoproliferation, autoimmunity, enteropathy, bronchiectasis, increased risk lymphoma, and early mortality. Hyperactive PI3Kδ signaling causes APDS selectively targeted leniolisib, oral, small molecule inhibitor PI3Kδ. Here, 31 patients aged ≥12 years were enrolled in a global, phase 3, triple-blinded trial randomized 2:1 to receive 70...
Interferon (IFN) consensus sequence-binding protein/IFN regulatory factor 8 (IRF8) is a transcription that regulates the differentiation and function of macrophages, granulocytes, dendritic cells through activation or repression target genes. Although IRF8 also expressed in lymphocytes, its roles B cell T maturation are ill defined, few transcriptional targets known. Gene expression profiling human tonsillar mouse lymphomas showed transcripts were at highest levels centroblasts, either from...
The TNF family member protein BAFF/BLyS is essential for B cell survival and plays an important role in regulating class switch recombination as well the selection of autoreactive cells. In humans, increased concentrations soluble BAFF are found different pathological conditions, which may be diverse autoimmune diseases, malignancies, primary Ab deficiencies (PAD). Because mechanisms that regulate levels not understood, we newly developed a set mAbs against human to study parameters...
We aimed to test the relevance of deficiency adenosine deaminase 2 (DADA2) in patients with antibody and describe clinical picture disease adulthood.We screened for DADA2 a cohort 181 or without vascular lesions using next-generation sequencing targeted Sanger sequencing. All mutations were confirmed by determining ADA2 enzymatic activity levels dried plasma spots. Clinical data laboratory values collected standardized format.Following diagnosis siblings index family, we identified 9...
Memory B cells (MBCs) epitomize the adaptation of immune system to environment. We identify two MBC subsets in peripheral blood, CD27dull and CD27bright MBCs, whose frequency changes with age. Heavy chain variable region (VH) usage, somatic mutation replacement-to-silent ratio, CDR3 property changes, reflecting consecutive selection highly antigen-specific, low cross-reactive antibody variants, all demonstrate that MBCs represent sequential developmental stages, stringent antigen-driven...
Clinical Implications•Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients with inborn errors of immunity (IEI) showed a similar infection-fatality rate, lower incidence in pediatric age, and younger age at death than the SARS-CoV-2–positive Italian population. The fatality rate was previously reported from other IEI cohorts. Antibody deficiencies long-lasting SARS-CoV-2 positivity. •Severe Early reports described an unexpected low number affected by severe...
Gastrointestinal manifestations and villous atrophy can be seen in patients with common variable immunodeficiency (CVID). In some patients, infectious agents may responsible, whereas others, celiac disease (CD) the cause. this study, we investigate causes histopathologic features CVID. Eleven CVID underwent duodenal biopsies, human leukocyte antigen (HLA) typing, testing for all antibodies. Fifteen normal villi 6 CD but without served as controls. Histologic response to a gluten-free diet...
BackgroundLacking protective antibodies, patients with primary antibody deficiencies (PADs) experience frequent respiratory tract infections, leading to chronic pulmonary damage. Macrolide prophylaxis has proved effective in diseases.ObjectiveWe aimed test the efficacy and safety of orally administered low-dose azithromycin PADs.MethodsWe designed a 3-year, double-blind, placebo-controlled, randomized clinical trial whether oral (250 mg once daily 3 times week for 2 years) would reduce...
Background: Recently, a growing number of novel genetic defects underlying primary immunodeficiencies (PID) have been identified, increasing the PID up to more than 250 well-defined forms. Next-generation sequencing (NGS) technologies and proper filtering strategies greatly contributed this rapid evolution, providing possibility rapidly simultaneously analyze large numbers genes or whole exome. Objective: To evaluate role targeted next-generation exome in diagnosis case series, characterized...
Article21 January 2021Open Access Source DataTransparent process Modeling, optimization, and comparable efficacy of T cell hematopoietic stem gene editing for treating hyper-IgM syndrome Valentina Vavassori San Raffaele Telethon Institute Gene Therapy, IRCCS Scientific Institute, Milan, Italy Vita-Salute University, ItalyThese authors contributed equally to this work Search more papers by author Elisabetta Mercuri Milano-Bicocca Monza, Genni E Marcovecchio Maria C Castiello Genetic...